公开(公告)号：US20090304694A1

公开(公告)日：2009-12-10

申请号：US12223003

申请日：2007-01-19

Applicant: Jonathan Oliner ,  Richard Kendall ,  Rakesh Kumar

Inventor： Jonathan Oliner ,  Richard Kendall ,  Rakesh Kumar

IPC: A61K39/395 ,  A61P35/00

CPC classification number: A61K31/435 ,  A61K38/16 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides methods for using Ang2 inhibitors in combination with VEGF inhibitors to treat disease. The invention also provides compositions, kits, formulations, and specific disease treatments relating thereto.

Abstract translation: 本发明提供了使用Ang2抑制剂与VEGF抑制剂组合治疗疾病的方法。 本发明还提供了与其有关的组合物，试剂盒，制剂和特定疾病治疗。

公开(公告)号：US20090285987A1

公开(公告)日：2009-11-19

申请号：US12510038

申请日：2009-07-27

Applicant: William R. Dolbier, JR. ,  Puhui Xie ,  Rakesh Kumar

Inventor： William R. Dolbier, JR. ,  Puhui Xie ,  Rakesh Kumar

IPC: C07C23/18 ,  B05D3/10 ,  C23C16/00 ,  C07C25/13

CPC classification number: C07C17/392 ,  C07C17/269 ,  C08F14/18 ,  C07C25/22 ,  C08F2/04

Abstract: A composition comprising perfluoro-[2,2]-paracyclophane dimer compound is disclosed. The synthesis reaction of the paracyclophane dimer from 1,4-bis(chlorodifluoromethane)-2,3,5,6-tetrafluorobenzene involves heating in the presence of a metal catalyst and a solvent. A perfluorinated paraxylylene coating formed from the perfluorinated paracyclophane dimer is also disclosed.

Abstract translation: 公开了包含全氟 - [2,2] - 对环烷基二聚体化合物的组合物。 来自1,4-双（氯二氟甲烷）-2,3,5,6-四氟苯的对环烷基二聚体的合成反应涉及在金属催化剂和溶剂的存在下加热。 还公开了由全氟化对环烷基二聚体形成的全氟化对二甲苯涂层。

公开(公告)号：US07588882B2

公开(公告)日：2009-09-15

申请号：US10945897

申请日：2004-09-22

Applicant: Filippo Romanato ,  Enzo Di Fabrizio ,  Rakesh Kumar

Inventor： Filippo Romanato ,  Enzo Di Fabrizio ,  Rakesh Kumar

IPC: H01L21/02

CPC classification number: G03F7/00 ,  G03F7/095 ,  G03F7/201 ,  G03F7/2014 ,  G03F7/203

Abstract: What is described is a lithographic method for fabricating three-dimensional structures on the micrometric and submicro-metric scale, including the operations of: depositing a layer of a first resist on a substrate; depositing a layer of a second resist on the layer of the first resist; forming a pattern of the second resist by lithography; depositing a further layer of the first resist on the previous layers; and forming a pattern of the first resist by lithography. The second resist is sensitive to exposure to charged particles or to electromagnetic radiation in a different way from the first; in other words, it is transparent to the particles or to the electromagnetic radiation to which the first resist is sensitive, and therefore the processes of exposure and development of the two resists are mutually incompatible to the extent that the exposure and development of one does not interfere with the exposure and development of the other.

Abstract translation: 描述的是用于在微米和亚微米度量上制造三维结构的光刻方法，包括以下操作：在衬底上沉积第一抗蚀剂层; 在第一抗蚀剂的层上沉积第二抗蚀剂层; 通过光刻形成第二抗蚀剂的图案; 在先前的层上沉积另一层第一抗蚀剂层; 以及通过光刻形成第一抗蚀剂的图案。 第二抗蚀剂以与第一抗蚀剂不同的方式对暴露于带电粒子或电磁辐射敏感; 换句话说，对于第一抗蚀剂敏感的颗粒或电磁辐射是透明的，因此两种抗蚀剂的曝光和显影的过程相互不相容，使得曝光和显影不会 干扰另一方的曝光和发展。

公开(公告)号：US07551550B2

公开(公告)日：2009-06-23

申请号：US11128158

申请日：2005-05-13

Applicant: Rakesh Kumar Sinha

Inventor： Rakesh Kumar Sinha

IPC: G01R31/08

CPC classification number: H04L45/00 ,  H04L45/22 ,  H04L45/30

Abstract: An embodiment of the invention is a method of allocating protection path resources including obtaining a link vector for a plurality of protection paths. The link vector includes a plurality of link vector elements. A proposed link vector is determined for each of the protection paths. The proposed link vector includes a plurality of proposed link vector elements and is indicative of allocating a respective protection path to a working path. A link cost is determined based on the proposed link vector and the obtained link vector. A path cost is determined for at least two protection paths based on the past cost.

Abstract translation: 本发明的实施例是一种分配保护路径资源的方法，包括获得多个保护路径的链路向量。 链接向量包括多个链接向量元素。 为每个保护路径确定所提出的链接向量。 所提出的链路向量包括多个提出的链路向量元素，并且指示将相应的保护路径分配到工作路径。 基于所提出的链接向量和获得的链接向量来确定链路成本。 基于过去的成本确定至少两个保护路径的路径成本。

公开(公告)号：US20090131430A1

公开(公告)日：2009-05-21

申请号：US11720047

申请日：2005-11-23

Applicant: Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

Inventor： Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

IPC: A61K31/5377 ,  C07D471/04 ,  A61P29/00 ,  A61K31/519

CPC classification number: C07D471/04

Abstract: The present invention relates to novel azabicyclo derivatives as anti-inflammatory agents. The compounds provided herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis. Also provided herein are pharmacological compositions containing compounds provided herein and associated methods of treating sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, and other inflammatory and/or autoimmune disorders, using the compounds.

Abstract translation: 本发明涉及新型的氮杂二环衍生物作为抗炎剂。 本文提供的化合物可用于抑制和预防炎症和相关病理，包括炎性和自身免疫性疾病，例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣。 本文还提供含有本文提供的化合物的药物组合物和治疗败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣以及其它炎性和/或自身免疫性疾病的相关方法 ，使用该化合物。

公开(公告)号：US20090036472A1

公开(公告)日：2009-02-05

申请号：US11815251

申请日：2006-02-01

Applicant: Venkata P. Palle ,  Ashwani Verma ,  Rakesh Kumar Singh ,  Yogesh Bhaskarrao Waman ,  Arti Walia ,  Abhijit Ray ,  Geeta Sharma

Inventor： Venkata P. Palle ,  Ashwani Verma ,  Rakesh Kumar Singh ,  Yogesh Bhaskarrao Waman ,  Arti Walia ,  Abhijit Ray ,  Geeta Sharma

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P19/02 ,  A61P11/00 ,  A61P9/00 ,  A61P3/00 ,  A61P3/10 ,  A61P1/00

CPC classification number: C07D471/04

Abstract: The present invention relates to novel azabicyclo derivatives of Formula (I) as anti-inflammatory agents which are useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis.

Abstract translation: 本发明涉及式（I）的新型氮杂双环衍生物作为抗炎剂，其可用于抑制和预防炎症和相关病理学，包括炎性和自身免疫疾病如败血症，类风湿性关节炎，炎性肠病，1型糖尿病 ，哮喘，慢性阻塞性肺病，器官移植排斥和牛皮癣。

公开(公告)号：US07462750B2

公开(公告)日：2008-12-09

申请号：US11263597

申请日：2005-10-31

Applicant: Phillip Hanefeld ,  Sven Horst ,  Markus Meise ,  Michael Bognitzki ,  Andreas Greiner ,  Rakesh Kumar

Inventor： Phillip Hanefeld ,  Sven Horst ,  Markus Meise ,  Michael Bognitzki ,  Andreas Greiner ,  Rakesh Kumar

IPC: C07C22/00 ,  C07C19/08

CPC classification number: C07C22/08 ,  C07C17/269 ,  C07C17/35 ,  C07C17/354 ,  C07C2603/92 ,  C08G61/02 ,  C09D165/00 ,  Y10T428/12028

Abstract: Fluorinated paracyclophane compounds represented by the formula where least one of R1 and R2 comprises a fluorinated moiety is disclosed. These compounds can be utilized as precursor dimer compounds to produce polymeric coatings comprising copolymers of trifluorinated paraxylylene.

Abstract translation: 公开了由下式表示的氟化对环烷化合物，其中R1和R2中至少一个包含氟化部分。 这些化合物可以用作前体二聚体化合物以产生包含三氟化对二甲苯的共聚物的聚合物涂层。

公开(公告)号：US20080242676A1

公开(公告)日：2008-10-02

申请号：US12137170

申请日：2008-06-11

Applicant: Sudershan Kumar Arora ,  Neelima Sinha ,  Sanjay Jain ,  Ram Shankar Upadhayaya ,  Gourhari Jana ,  Shankar Ajay ,  Rakesh Kumar Sinha

Inventor： Sudershan Kumar Arora ,  Neelima Sinha ,  Sanjay Jain ,  Ram Shankar Upadhayaya ,  Gourhari Jana ,  Shankar Ajay ,  Rakesh Kumar Sinha

IPC: A61K31/496 ,  C07D403/02 ,  C12N1/00 ,  C12N1/20 ,  A61P31/04

CPC classification number: C07D207/335 ,  C07D207/32 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/06

Abstract: Novel pyrrole derivatives of formula (I) and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacterium tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).

Abstract translation: 式（I）的新型吡咯衍生物及其药学上可接受的酸加成盐对临床敏感性以及抗结核分枝杆菌菌株具有优异的抗分枝杆菌活性，并且与已知化合物相比具有较小的毒性。 使用式（I）的新化合物用于治疗潜在结核病，包括多药耐药性结核病（MDR TB）。 制备新化合物的方法，含有新化合物的药物组合物和通过施用式（I）化合物治疗MDR TB的方法。

公开(公告)号：US20080022903A1

公开(公告)日：2008-01-31

申请号：US11491916

申请日：2006-07-25

Applicant: Rakesh Kumar ,  Sanjay Kumar ,  Amitava Bandopadhaya ,  Surya Pratap Mehrotra

Inventor： Rakesh Kumar ,  Sanjay Kumar ,  Amitava Bandopadhaya ,  Surya Pratap Mehrotra

IPC: C04B7/19 ,  C04B7/14 ,  C04B2/10

CPC classification number: C04B28/04 ,  C04B18/141 ,  Y02W30/94 ,  C04B20/008 ,  C04B20/026

Abstract: Accordingly, the present invention provides an improved process for the production of Portland slag cement using granulated blast furnace slag, which comprises: (viii) forming of cement clinker by known process, (ix) ball-milling of cement clinker for a period ranging between 30-60 minutes in dry condition, (x) reducing size of granulated blast furnace slag by any process to obtain the size in the range between 210 to 100 μm for using as feed for attrition mill, (xi) wet milling of granulated blast furnace slag for a period ranging between 5-15 minutes in an attrition mill using granulated blast furnace slag to water ratio in the range of 1:1 to 1:2 and granulated blast furnace slag to grinding bail ratio in the range of 1:5 to 1:15, (xii) removing water from the slurry obtained after attrition milling by known process, (xiii) drying of the obtained slurry by known process, (xiv) mixing intimately of: attrition milled slag obtain in step (vi) in the range of: 50 to 95% by weight ball-milled clinker obtain in step (ii) in the range of: 05 to 45% by weight gypsum in the range of: 01 to 05% by weight for a period in the range of 15 to 30 minutes.

Abstract translation: 因此，本发明提供了一种使用造粒高炉矿渣生产波特兰矿渣水泥的改进方法，其包括：（viii）通过已知方法形成水泥熟料，（ix）水泥熟料的球磨，时间范围 在干燥条件下30-60分钟，（x）通过任何工艺减少造粒高炉矿渣的尺寸，以获得用于磨粉机进料的210至100um之间的尺寸，（xi）造粒高炉的湿磨 在磨粉机中使用造粒高炉矿渣与水的比例在1：1至1：2范围内的炉渣在5-15分钟之间，并将造粒高炉矿渣与1：5至 （xii）通过已知方法磨碎后得到的浆料中的水，（xiii）通过已知方法干燥所获得的浆料，（xiv）密切混合：步骤（vi）中获得的磨碎的炉渣 范围：50〜95重量％ 研磨熟料在步骤（ii）中获得的范围为：05至45重量％的石膏，其范围为：01至05重量％，范围为15至30分钟。

公开(公告)号：US20070070069A1

公开(公告)日：2007-03-29

申请号：US11527987

申请日：2006-09-26

Applicant: Supun Samarasekera ,  Rakesh Kumar ,  Taragay Oskiper ,  Harpreet Sawhney ,  Manoj Aggarwal

Inventor： Supun Samarasekera ,  Rakesh Kumar ,  Taragay Oskiper ,  Harpreet Sawhney ,  Manoj Aggarwal

IPC: G06T15/20

CPC classification number: G06T17/05 ,  G06F3/011 ,  G06F16/748

Abstract: The present invention provides a system and method for processing real-time rapid capture, annotation and creation of an annotated hyper-video map for environments. The method includes processing video, audio and GPS data to create the hyper-video map which is further enhanced with textual, audio and hyperlink annotations that will enable the user to see, hear, and operate in an environment with cognitive awareness. Thus, this annotated hyper-video map provides a seamlessly navigable, situational awareness and indexable high-fidelity immersive visualization of the environment.

Abstract translation: 本发明提供了一种用于处理用于环境的带注释的超视频映射的实时快速捕获，注释和创建的系统和方法。 该方法包括处理视频，音频和GPS数据以创建超视频地图，其进一步增强了文本，音频和超链接注释，这将使用户能够在具有认知意识的环境中看到，听到和操作。 因此，该注释的超视频地图提供了无缝导航的情境感知和可索引的高保真度的环境可视化。