公开(公告)号：US11198951B2

公开(公告)日：2021-12-14

申请号：US15316555

申请日：2015-06-05

Applicant: University of Southampton

Inventor： Frederic Yannick Gardes ,  Graham Trevor Reed ,  Callum George Littlejohns

IPC: C30B29/52 ,  H01L21/02 ,  C30B11/00 ,  C30B13/14 ,  C30B13/22 ,  C30B13/34 ,  C30B29/06 ,  C30B29/08 ,  C30B29/18

Abstract: A method of fabricating at least one single-crystal alloy semiconductor structure. At least one seed, containing an alloying material, on a substrate for growth of at least one single-crystal alloy semiconductor structure is formed. At least one structural form, formed of a host material, on the substrate is crystallized to form the at least one single-crystal alloy semiconductor structure. The at least one structural form is heated such that the material of the at least one structural form has a liquid state. Also, the at least one structural form is cooled, such that the material of the at least one structural form nucleates at the least one seed and crystallizes as a single crystal to provide at least one single-crystal alloy semiconductor structure, with a growth front of the single crystal propagating in a main body of the respective structural form away from the respective seed.

公开(公告)号：US20210311248A1

公开(公告)日：2021-10-07

申请号：US17266408

申请日：2019-08-05

Applicant: University of Southampton

Inventor： Austin Taranta ,  Eric Numkam-Fokoua ,  Francesco Poletti ,  David Neil Payne

IPC: G02B6/02

Abstract: An interferometric optical fibre sensor comprises optical fibre defining an optical circuit configured to propagate a first optical wave via an environment in which the optical fibre can be exposed to a stimulus that modifies the first optical wave, and a second optical wave, and to combine the first optical wave and the second optical wave to create an interference signal containing information about the stimulus, wherein optical fibre propagating either or both of the first optical wave and the second optical wave comprises hollow core optical fibre configured to propagate the optical wave or waves by an antiresonant optical guidance effect.

公开(公告)号：US11103604B2

公开(公告)日：2021-08-31

申请号：US14888908

申请日：2014-05-02

Applicant: GE Healthcare Limited ,  University of Southampton

Inventor： Rajiv Bhalla ,  Gill Reid ,  William Levason

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  C07F5/00 ,  C07D255/02

Abstract: A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.

公开(公告)号：US11034607B2

公开(公告)日：2021-06-15

申请号：US15023541

申请日：2014-09-19

Applicant: University of Southampton

Inventor： Eric Rodrigue Numkam Fokoua ,  Francesco Poletti ,  David John Richardson ,  Yong Chen ,  Natalie Violet Wheeler ,  John Richard Hayes ,  Marco Petrovich

IPC: C03B37/012 ,  C03B37/027 ,  G02B6/02

Abstract: A method of fabricating a hollow-core photonic-bandgap fiber, comprising the steps of: providing a stack of capillaries, wherein the stack has a hollow core and the capillaries at a boundary of the core comprise a plurality of first, corner core capillaries and a plurality of second, intermediate core capillaries; applying a pressure differential between the corner core capillaries and the intermediate core capillaries, whereby a size of the corner core capillaries can be controlled in relation to the intermediate core capillaries; and reducing the stack to a fiber, wherein the fiber has a hollow core and a cladding which surrounds the core at a core boundary and comprises a lattice or network of struts and interstitial nodes which together define an array of cavities.

公开(公告)号：US20210088717A1

公开(公告)日：2021-03-25

申请号：US16635200

申请日：2018-08-01

Applicant: University of Southampton

Inventor： Gregory Teofil JASION ,  Francesco POLETTI ,  Yong CHEN ,  Eric Rodrigue Numakm FOKOUA ,  Thomas David BRADLEY

IPC: G02B6/02 ,  C03B37/012 ,  C03B37/027

Abstract: A hollow core photonic bandgap optical fibre comprises: a cladding comprising capillaries in a hexagonal array and a hollow core formed by excluding a hexagonal group of nineteen capillaries from the centre of the hexagonal array. The core is inflated. A core size ratio is 1.26 or above, defined as a ratio of the core diameter to the cladding diameter normalized to the ratio of the core diameter to the cladding diameter in an undistorted hexagonal array; a first ring ratio is between 0.55 and 2.50, defined as a ratio of the length of radially aligned struts separating the capillaries of the first ring to the length of a strut in an undistorted hexagonal array; and a core node spacing is between 0.60 and 1.90, where defined as a ratio of a strut length around the core of a largest corner capillary and a strut length around the core of a smallest side capillary. The fabrication method comprises four different pressures for the core, corner capillary, side capillary and cladding.

公开(公告)号：US20210040428A1

公开(公告)日：2021-02-11

申请号：US16965767

申请日：2019-01-17

Applicant: University of Southampton

Inventor： Hywel MORGAN ,  Riccardo REALE

IPC: C12M3/06 ,  C12M1/34 ,  G01N33/483

Abstract: A microfluidic device is provided for studying primary human airway cells cultured at the air-liquid interface defined in the device by a barrier between an apical and basolateral compartment provided by a porous support for growing a cell layer. Within the chip, a liquid flow channel is provided through the basolateral compartment. Primary measurement electrodes are arranged widely spaced apart in the basolateral compartment to cause a significant component of electrical current flowing between them to flow via the cell layer. Secondary measurement electrodes are also provided to make comparative measurements which are used to deduce parameters that are relevant for the equivalent circuit model use for analysing the data obtained from the primary measurement electrodes. The microfluidic device has a modular construction of substrate, spacer and sidewall piece, with the electrodes being formed on the substrate, and the substrate and spacer co-defining the flow channel.

公开(公告)号：US20200088943A1

公开(公告)日：2020-03-19

申请号：US16580298

申请日：2019-09-24

Applicant: University of Southampton

Inventor： Xia Chen ,  Milan Milosevic ,  Graham Trevor Reed ,  David John Thomson

IPC: G02B6/134 ,  C23C14/48 ,  G01M11/00

Abstract: The disclosure provides a method of forming an erasable optical coupler in a photonic device comprising a conventional optical waveguide formed in a crystalline wafer. The method comprises selectively implanting ions in a localized region of the wafer material adjacent to the conventional waveguide of the photonic device, to cause modification of the crystal lattice structure of, and a change in refractive index in, the ion implanted region of the wafer material to thereby form an ion implanted waveguide optically coupled to the adjacent conventional waveguide to couple light out therefrom, or in thereto. The crystalline wafer material and ion implanted waveguide are such that the crystal lattice structure or composition can be modified to adjust or remove the optical coupling with the conventional waveguide by further modification of the refractive index in the ion implanted region.

公开(公告)号：US20200078401A1

公开(公告)日：2020-03-12

申请号：US16465983

申请日：2017-12-07

Applicant: La Jolla Institute for Allergy and Immunology ,  UNIVERSITY OF SOUTHAMPTON

Inventor： Pandurangan VIJAYANAND ,  Christian OTTENSMEIER ,  Anusha Preethi GANESAN ,  James CLARKE ,  Tilman SANCHEZ-ELSNER

IPC: A61K35/17 ,  A61P35/00 ,  C12Q1/6886

Abstract: Global transcriptional profiling of CTLs in tumors and adjacent non-tumor tissue from treatment-naive patients with early stage lung cancer revealed molecular features associated with robustness of anti-tumor immune responses. Major differences in the transcriptional program of tumor-infiltrating CTLs were observed that are shared across tumor subtypes. Pathway analysis revealed enrichment of genes in cell cycle, T cell receptor (TCR) activation and co-stimulation pathways, indicating tumor-driven expansion of presumed tumor antigen-specific CTLs. Marked heterogeneity in the expression of molecules associated with TCR activation and immune checkpoints such as 4-1BB, PD1, TIM3, was also observed and their expression was positively correlated with the density of tumor-infiltrating CTLs. Transcripts linked to tissue-resident memory cells (TRM), such as CD 103, were enriched in tumors containing a high density of CTLs, and CTLs from CD 103high tumors displayed features of enhanced cytotoxicity, implying better anti-tumor activity. In an independent cohort of 689 lung cancer patients, patients with CD103high (TRM rich) tumors survived significantly longer. In summary, the molecular fingerprint of tumor-infiltrating CTLs at the site of primary tumor was defined and a number of novel targets identified that appear to be important in modulating the magnitude and specificity of anti-tumor immune responses in lung cancer.

公开(公告)号：US10578803B2

公开(公告)日：2020-03-03

申请号：US15512674

申请日：2015-09-21

Applicant: University of Southampton

Inventor： Youfang Hu ,  Graham Reed ,  David Thomson

IPC: G02B6/293 ,  G02B6/126 ,  G02B6/28 ,  G02B6/12

Abstract: An optical demultiplexer/multiplexer, comprising: a multimode interference waveguide; at least one first coupling waveguide which meets the multimode interference waveguide at least one first location and a plurality of second coupling waveguides which meet the multimode interference waveguide at a plurality of second locations which are spaced in a direction of transmission in relation to the at least one first location, with the at least one first coupling waveguide and the second coupling waveguides together with the multimode interference waveguide providing a first angled multimode interferometer which operates to demultiplex a first optical signal having optical channels of a plurality of wavelengths or multiplex optical signals of a plurality of wavelengths into a first optical signal having optical channels of the plurality of wavelengths; at least one third coupling waveguide which meets the multimode interference waveguide at least one third location and a plurality of fourth coupling waveguides which meet the multimode interference waveguide at a plurality of fourth locations which are spaced in a direction of transmission in relation to the at least one third location, with the at least one third coupling waveguide and the plurality of fourth coupling waveguides together with the multimode interference waveguide providing a second angled multimode interferometer which operates to demultiplex a second optical signal having optical channels of a plurality of wavelengths or multiplex optical signals of a plurality of wavelengths into a second optical signal having optical channels of the plurality of wavelengths; whereby the demultiplexer/multiplexer provides for the demultiplexing/multiplexing of first and second optical signals having optical channels of a plurality of wavelengths. In a further embodiment the first coupling waveguide of an optical demultiplexer/multiplexer comprising a first angled multimode interferometer is stepped or tapered in order to couple a signal having a broadened spatial, or spectral, profile. In another embodiment of an optical demultiplexer/multiplexer comprising a first angled multimode interferometer a plurality of first coupling waveguides are coupled to a photonic structure which provides a plurality of output signals having substantially equal intensity and a phase difference, also in order to couple a signal or signals having a broadened spatial, or spectral, profile. In yet another embodiment of an optical demultiplexer/multiplexer comprising a first angled multimode interferometer the multimode interference waveguide includes a reflector at one end.

公开(公告)号：US20200057197A1

公开(公告)日：2020-02-20

申请号：US15999071

申请日：2018-08-17

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： Harold Chong ,  Rafidah Petra ,  Graham Reed ,  Swe Zin Oo ,  Antulio Tarazona

IPC: G02B6/122

Abstract: An integrated photonic device comprising at least a first integrated photonic component supported by a substrate extending substantially in a plane of the device and optically isolating cladding facing the first integrated photonic component, the photonic device further comprising a waveguide formed by a deposited layer of group IV semiconductor material to extend on a slope in a direction out of the plane of the substrate, the waveguide arranged to, in use, couple light from/to the integrated photonic component through the optically isolating cladding.