公开(公告)号：USD833048S1

公开(公告)日：2018-11-06

申请号：US29630025

申请日：2017-12-19

申请人： Yi Chen

设计人： Yi Chen

公开(公告)号：US09206442B2

公开(公告)日：2015-12-08

申请号：US13457791

申请日：2012-04-27

申请人： Yi Chen

发明人： Yi Chen

IPC分类号： C12P1/00 ,  A61K35/12 ,  A61L27/56 ,  A61L27/36

CPC分类号： A61L27/3687 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3662 ,  A61L27/3695 ,  A61L27/56 ,  A61L2430/40 ,  C12P1/00

摘要： Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix.

摘要翻译： 提供了根据方法制备的组织基质和组织基质的方法。 该方法可以包括用蛋白水解酶处理组织基质以产生组织基质所需的柔韧性。

公开(公告)号：US08911968B2

公开(公告)日：2014-12-16

申请号：US13994633

申请日：2011-12-15

申请人： Yi Chen ,  Shidong Liu ,  Zhaoli Zhang ,  Chunxia Wang ,  Jing Kang ,  Xiaoming Ji

发明人： Yi Chen ,  Shidong Liu ,  Zhaoli Zhang ,  Chunxia Wang ,  Jing Kang ,  Xiaoming Ji

IPC分类号： C12P21/04 ,  C07K7/54 ,  C12R1/645 ,  C12N15/01 ,  C12N1/14 ,  C07K7/56

CPC分类号： C07K7/54 ,  C07K7/56 ,  C12N1/14 ,  C12N15/01 ,  C12R1/645

摘要： High-yield antibiotics producing strain, preparation method and use thereof are provided in the present invention. The high-yield strain is a mutagenized strain derived from Colephoma empetri, and deposited in CGMCC with the accession number of CGMCC 4129. The preparation method comprises the following steps: (a) mixing a seed liquid of Colephoma empetri of Accession No. FERM BP-2635 with nitrosoguanidine to obtain a mixture a; (b) mixing said mixture a with a wall-breaking enzyme to obtain protoplasts; (c) regenerating said protoplasts to obtain single colonies; and (d) culturing said single colonies to obtain said mutagenized strain. The obtained strain has stable genetic and producing property, produces little impurities in fermentation, and is suitable for industrialization.

摘要翻译： 本发明提供了高产抗生素生产菌株，其制备方法和用途。 高产菌株是来自科氏白菜的诱变菌株，保藏在CGMCC的CGMCC中，登录号为CGMCC 4129.该制备方法包括以下步骤：（a）将加入号为FERM BP的Colephoma empetri种子液 -2635与亚硝基胍混合得到混合物; （b）将所述混合物a与破壁酶混合以获得原生质体; （c）再生所述原生质体以获得单个菌落; 和（d）培养所述单个菌​​落以获得所述诱变菌株。 得到的菌株具有稳定的遗传和生产特性，发酵中杂质少，适用于工业化。

公开(公告)号：US08900465B1

公开(公告)日：2014-12-02

申请号：US13539103

申请日：2012-06-29

申请人： Yang Yun ,  Xiaofeng Yao ,  Yi Chen ,  Paul C. Dorsey

发明人： Yang Yun ,  Xiaofeng Yao ,  Yi Chen ,  Paul C. Dorsey

IPC分类号： B44C1/22 ,  G11B5/84

CPC分类号： G11B5/84 ,  G11B5/8408 ,  Y10T29/49025 ,  Y10T29/49032

摘要： Methods for reducing the surface roughness of magnetic media to be used in storage drives are described. One such method includes forming a recording media on a substrate, the recording media including at least one recording layer configured to store information magnetically, depositing a first layer of carbon on the recording media, the first carbon layer having a first average preselected thickness, etching the first carbon layer to have a second average preselected thickness less than the first average preselected thickness, depositing a second layer of carbon on the etched first carbon layer, the second carbon layer having a third average preselected thickness that is less than the first average preselected thickness, and implanting nitrogen in the second carbon layer.

摘要翻译： 描述了用于降低在存储驱动器中使用的磁性介质的表面粗糙度的方法。 一种这样的方法包括在基板上形成记录介质，所述记录介质包括至少一个记录层，其被配置为磁性存储信息，在记录介质上沉积第一层碳，所述第一碳层具有第一平均预选厚度，蚀刻 所述第一碳层具有小于所述第一平均预选厚度的第二平均预选厚度，在所述蚀刻的第一碳层上沉积第二层碳，所述第二碳层具有小于所述第一平均预选厚度的第三平均预选厚度 厚度和在第二碳层中注入氮气。

公开(公告)号：US20140296216A1

公开(公告)日：2014-10-02

申请号：US14125304

申请日：2011-12-21

申请人： Ke Ding ,  Shaohua Chang ,  Shilin Xu ,  Lianwen Zhang ,  Zhengchao Tu ,  Jian Ding ,  Meiyu Geng ,  Yi Chen

发明人： Ke Ding ,  Shaohua Chang ,  Shilin Xu ,  Lianwen Zhang ,  Zhengchao Tu ,  Jian Ding ,  Meiyu Geng ,  Yi Chen

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551

摘要： A compound of formula (I) or (II) and use of the compound in the preparation of drugs for treating cancer are disclosed. The study shows that the compounds can inhibit the growth of many kinds of tumor cells, can be used for targeting epidermal growth factor receptor (EGFR), and particularly can inhibit tumor cells with single or multiple mutations of EGFR (T790M). Therefore, the compound can be used as EGFR inhibitor to treat cancer and has a relatively large application value.

摘要翻译： 公开了式（I）或（II）的化合物和该化合物在制备用于治疗癌症的药物中的用途。 该研究表明，该化合物可抑制多种肿瘤细胞的生长，可用于靶向表皮生长因子受体（EGFR），特别是可以单独或多次EGFR（T790M）突变抑制肿瘤细胞。 因此，该化合物可用作EGFR抑制剂治疗癌症，具有较大的应用价值。

公开(公告)号：US20140281161A1

公开(公告)日：2014-09-18

申请号：US13995919

申请日：2013-03-14

申请人： Yi Chen ,  Yukiyasu Murakami

发明人： Yi Chen ,  Yukiyasu Murakami

IPC分类号： G06F12/02

CPC分类号： G06F3/0611 ,  G06F3/065 ,  G06F3/0688 ,  G06F12/0246 ,  G06F13/161 ,  G06F2212/7208

摘要： Described embodiments include memory systems that may shadow certain data stored in a first memory device (e.g. NAND flash device) onto a second memory device (e.g. DRAM device). Memory systems may train and/or re-organize stored data to facilitate the selection of data to be shadowed. Initial responses to memory commands may be serviced from the first memory device, which may have a lower latency than the second memory device. The remaining data may be serviced from the second memory device. A controller may begin to access the remaining data while the initial response is being provided from the first memory device, which may reduce the apparent latency associated with the second memory device.

摘要翻译： 所描述的实施例包括可以将存储在第一存储器件（例如NAND闪存器件）中的某些数据影射到第二存储器件（例如DRAM器件）上的存储器系统）。 存储器系统可以训练和/或重新组织存储的数据以便于选择要被镜像的数据。 可以从第一存储器设备处理对存储器命令的初始响应，其可以具有比第二存储器设备更低的延迟。 剩余的数据可以从第二存储器设备服务。 当从第一存储设备提供初始响应时，控制器可以开始访问剩余的数据，这可以减少与第二存储器设备相关联的表观等待时间。

公开(公告)号：US20140162314A1

公开(公告)日：2014-06-12

申请号：US13994633

申请日：2011-12-15

申请人： Yi Chen ,  Shidong Liu ,  Zhaoli Zhang ,  Chunxia Wang ,  Jing Kang ,  Xiaoming Ji

发明人： Yi Chen ,  Shidong Liu ,  Zhaoli Zhang ,  Chunxia Wang ,  Jing Kang ,  Xiaoming Ji

IPC分类号： C07K7/54

CPC分类号： C07K7/54 ,  C07K7/56 ,  C12N1/14 ,  C12N15/01 ,  C12R1/645

摘要： High-yield antibiotics producing strain, preparation method and use thereof are provided in the present invention. The high-yield strain is a mutagenized strain derived from Colephoma empetri, and deposited in CGMCC with the accession number of CGMCC 4129. The preparation method comprises the following steps: (a) mixing a seed liquid of Colephoma empetri of Accession No. FERM BP-2635 with nitrosoguanidine to obtain a mixture a; (b) mixing said mixture a with a wall-breaking enzyme to obtain protoplasts; (c) regenerating said protoplasts to obtain single colonies; and (d) culturing said single colonies to obtain said mutagenized strain. The obtained strain has stable genetic and producing property, produces little impurities in fermentation, and is suitable for industrialization.

摘要翻译： 本发明提供了高产抗生素生产菌株，其制备方法和用途。 高产菌株是来自科氏白菜的诱变菌株，保藏在CGMCC的CGMCC中，登录号为CGMCC 4129.该制备方法包括以下步骤：（a）将加入号为FERM BP的Colephoma empetri种子液 -2635与亚硝基胍混合得到混合物; （b）将所述混合物a与破壁酶混合以获得原生质体; （c）再生所述原生质体以获得单个菌落; 和（d）培养所述单个菌​​落以获得所述诱变菌株。 得到的菌株具有稳定的遗传和生产特性，发酵中杂质少，适用于工业化。

公开(公告)号：US08732433B2

公开(公告)日：2014-05-20

申请号：US13219417

申请日：2011-08-26

申请人： Yi Chen ,  Yihua Zhang ,  Keith E. Winters

发明人： Yi Chen ,  Yihua Zhang ,  Keith E. Winters

IPC分类号： G06F12/02 ,  G06F12/06

CPC分类号： G06F12/0615 ,  G06F12/0607 ,  G06F12/0623

摘要： Apparatuses and methods for providing data are disclosed. An example apparatus includes a plurality of memories coupled to a data bus. The memories are configured to provide data to the data bus responsive, at least in part, to a first address. The plurality of memories are further configured to provide at least a portion of the data corresponding to the first address to the data bus during a sense operation for a second address provided to the plurality of memories after the first address. Each of the plurality of memories provides data to the data bus corresponding to the first address at different times. Moreover, a plurality of memories may be configured to provide at least 2N bits of data to the data bus responsive, at least in part, to an address, each of the plurality of memories configured to provide N bits of data to the data bus at different times.

摘要翻译： 公开了用于提供数据的装置和方法。 示例性装置包括耦合到数据总线的多个存储器。 存储器被配置为至少部分地响应于第一地址向数据总线提供数据。 多个存储器被进一步配置为在对于在第一地址之后提供给多个存储器的第二地址的感测操作期间，将与第一地址相对应的数据的至少一部分提供给数据总线。 多个存储器中的每一个在不同的时间向数据总线提供对应于第一地址的数据总线。 此外，多个存储器可以被配置为至少部分地提供地址，至少提供至少2N位的数据到数据总线，多个存储器中的每一个被配置为在数据总线上提供N位数据到数据总线 不同的时代。

公开(公告)号：US08682513B2

公开(公告)日：2014-03-25

申请号：US13443400

申请日：2012-04-10

申请人： Yi Chen ,  Jeffrey Twichel ,  Brian Meyer ,  Robert Palanti ,  Scott Sexauer

发明人： Yi Chen ,  Jeffrey Twichel ,  Brian Meyer ,  Robert Palanti ,  Scott Sexauer

IPC分类号： G06F17/00 ,  B61L3/12

CPC分类号： B61L15/0027 ,  B61L3/006 ,  B61L15/0036 ,  B61L15/0081

摘要： A communication management system for a vehicle includes a control module, a communication module, and a management module. The control module is disposed on-board a lead powered unit of the vehicle. The control module is configured to automatically change propulsion energy settings of a remote powered unit of the vehicle. The communication module transmits instructions to the remote powered unit to automatically change the propulsion energy settings of the remote powered unit. The communication module identifies communication gaps that represent interruption in one or more communication connections between the lead powered unit and the remote powered unit. The management module compares the propulsion energy settings of the lead powered unit and of the remote powered unit during the communication gaps and, based on the propulsion energy settings, prevents the control module from switching from automatic control of the propulsion energy settings of the remote powered unit to manual control.

摘要翻译： 车辆的通信管理系统包括控制模块，通信模块和管理模块。 控制模块被布置在车辆的引导动力单元上。 控制模块被配置为自动改变车辆的远程供电单元的推进能量设置。 通信模块向远程供电单元发送指令以自动改变远程供电单元的推进能量设置。 通信模块识别表示在牵引供电单元和远程供电单元之间的一个或多个通信连接中的中断的通信间隙。 管理模块在通信间隙期间比较牵引供电单元和远程供电单元的推进能量设置，并且基于推进能量设置，防止控制模块从远程供电的推进能量设置的自动控制切换 单位到手动控制。

公开(公告)号：US08672733B2

公开(公告)日：2014-03-18

申请号：US11703518

申请日：2007-02-06

申请人： Jie Chen ,  Aaron D. Herzon ,  Allan J. Reifel ,  Yi Chen

发明人： Jie Chen ,  Aaron D. Herzon ,  Allan J. Reifel ,  Yi Chen

IPC分类号： F24F11/00 ,  F24F11/02 ,  F24F7/00

CPC分类号： F04D27/004 ,  F24F11/77

摘要： Airflow rates within a ventilation system are controlled using motor speed or torque and motor electric current or pressure. Fan speed or torque may be varied to compensate for differing restriction in ductwork, and may provide a constant airflow rate over a range of varying airflow restriction. Air handlers or air conditioning units may be mass produced in common configurations, and installed in different buildings or structures with different ductwork configurations. Methods operate a fan motor at a present speed or torque, sample speed or torque, sample current of the fan motor or pressure within the ventilation system, calculate a present airflow rate within the ventilation system, calculate a new input setting using the present airflow rate and a target airflow rate, change the speed or torque to the new input setting, and repeat these steps to converge on the target airflow rate, often avoiding overshoot.

摘要翻译： 通风系统内的气流速率可通过电机转速或转矩，电机电流或压力进行控制。 可以改变风扇速度或扭矩以补偿管道系统中的不同限制，并且可以在变化的气流限制的范围内提供恒定的气流速率。 空气处理机或空调机可以通常配置大量生产，并安装在具有不同管道结构的不同建筑物或结构中。 方法以当前速度或扭矩，采样速度或扭矩，风扇电机的采样电流或通风系统内的压力来操作风扇电机，计算通风系统内的当前气流速率，使用当前气流速率计算新的输入设置 和目标气流速率，将速度或扭矩改变到新的输入设置，并重复这些步骤以收敛于目标气流速率，通常避免过冲。