公开(公告)号：US20090035253A1

公开(公告)日：2009-02-05

申请号：US11578712

申请日：2005-04-15

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino ,  Christine M. Smith ,  David Lokensgard ,  Mark Fineman ,  John Ong

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino ,  Christine M. Smith ,  David Lokensgard ,  Mark Fineman ,  John Ong

IPC: A61K38/00 ,  A61K38/02 ,  A61K38/17 ,  A61K39/395 ,  A61K38/20 ,  A61K38/28 ,  A61K38/21 ,  A61K38/43 ,  A61K38/22 ,  A61P3/10

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/2278 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

Abstract translation: 本发明涉及用于持续释放生物活性多肽的组合物，以及形成和使用所述组合物用于持续释放生物活性多肽的方法。 本发明的缓释组合物包含分散在其中的生物相容性聚合物，生物活性多肽和糖。

公开(公告)号：US07482792B2

公开(公告)日：2009-01-27

申请号：US11152280

申请日：2005-06-14

Applicant: Edward Burton ,  Peter Hazucha ,  Gerhard Schrom ,  Rajesh Kumar ,  Shekhar Y. Borkar

Inventor： Edward Burton ,  Peter Hazucha ,  Gerhard Schrom ,  Rajesh Kumar ,  Shekhar Y. Borkar

IPC: G05F1/59

CPC classification number: H02M7/003

Abstract: In general, in one aspect, the disclosure describes a semiconductor device that includes a functional circuit and a dc-to-dc power converter. The power converter converts, regulates, and filters a DC input voltage to produce a DC output voltage and provides the DC output voltage to the functional circuit. The dc-to-dc power converter has an operating frequency above 10 MHz.

Abstract translation: 通常，在一个方面，本公开描述了一种包括功能电路和DC-DC电力转换器的半导体器件。 电源转换器转换，调节和滤波直流输入电压以产生直流输出电压，并向功能电路提供直流输出电压。 直流 - 直流功率转换器的工作频率高于10 MHz。

公开(公告)号：US20080249335A1

公开(公告)日：2008-10-09

申请号：US11975141

申请日：2007-10-17

Applicant: Ashok L. Cholli ,  Rajesh Kumar ,  Taizoon Canteenwala ,  Vijayendra Kumar

Inventor： Ashok L. Cholli ,  Rajesh Kumar ,  Taizoon Canteenwala ,  Vijayendra Kumar

IPC: C07C233/01

CPC classification number: C07C235/38 ,  A61K8/42 ,  A61K2800/522 ,  A61Q1/00 ,  C10M133/16 ,  C10M2215/082 ,  C10N2230/10

Abstract: The present invention is directed to a compound represented by Structural Formula I: wherein the variables are described herein. Also included are methods of making the compounds of Structural Formula (I) and methods of using the compounds as antioxidants.

Abstract translation: 本发明涉及由结构式I表示的化合物：其中变量在本文中描述。 还包括制备结构式（I）的化合物和使用该化合物作为抗氧化剂的方法。

公开(公告)号：US07433358B1

公开(公告)日：2008-10-07

申请号：US11177939

申请日：2005-07-08

Applicant: Paul Volkaerts ,  Kevin Joseph Connor ,  James C. Frauenthal ,  Rajesh Kumar

Inventor： Paul Volkaerts ,  Kevin Joseph Connor ,  James C. Frauenthal ,  Rajesh Kumar

IPC: H04L12/56 ,  H04L12/28

CPC classification number: H04L47/10 ,  H04J3/0632 ,  H04L41/5003 ,  H04L41/5009 ,  H04L43/0829 ,  H04L43/0852 ,  H04L43/087 ,  H04L43/16 ,  H04L47/22 ,  H04L65/80 ,  H04M3/2236 ,  H04M7/006

Abstract: An embodiment may include an apparatus comprising a dejitter buffer to receive packets containing audio data, a codec coupled with the dejitter buffer, the codec to receive coded audio frames from the dejitter buffer and decode them, and a concealed seconds meter coupled with the dejitter buffer, the concealed seconds meter to record concealment events by the decoder to provide an objective measure of media impairment. Another exemplary embodiment may be a method comprising receiving packets containing audio information at a dejitter buffer, decomposing the packets to coded audio frames, sending the coded audio frames to a decoder and decoding the frames, generating a concealment output stream if the decoder does not receive a valid frame from the dejitter buffer, and recording concealment events to provide an objective measure of media impairment.

Abstract translation: 一个实施例可以包括一个装置，它包括一个去抖动缓冲器，用于接收包含音频数据的数据包，一个与该去抖动缓冲器耦合的编解码器，该编解码器用于从该去抖动缓冲器接收编码的音频帧并对它们进行解码，以及一个与该去抖动缓冲器耦合的隐藏秒表 ，隐形秒表由解码器记录隐藏事件，以提供媒体损害的客观量度。 另一个示例性实施例可以是一种方法，包括在去抖动缓冲器处接收包含音频信息的分组，将分组分解成编码音频帧，将编码音频帧发送到解码器并解码该帧，如果解码器没有接收到，则产生隐藏输出流 来自去抖动缓冲器的有效帧，以及记录隐藏事件以提供媒体损害的客观测量。

公开(公告)号：US20080233199A1

公开(公告)日：2008-09-25

申请号：US12051395

申请日：2008-03-19

Applicant: Rajesh Kumar ,  Gregory Troiano ,  J. Michael Ramstack ,  Paul Herbert ,  Michael Figa

Inventor： Rajesh Kumar ,  Gregory Troiano ,  J. Michael Ramstack ,  Paul Herbert ,  Michael Figa

IPC: A61K9/16 ,  A61K38/00

CPC classification number: A61K9/1647 ,  A61K9/1623 ,  A61K9/1682 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/2278

Abstract: Methods of forming compositions for the sustained release of water soluble active agents, including biologically active polypeptides and products produced by the process are described. Improved product characteristics and ease of scale-up can be achieved using a novel coacervation process wherein at least one coacervation agent is added to the mixture comprising the active agent and the polymer in at least two distinct stages.

Abstract translation: 描述了形成用于持续释放水溶性活性剂（包括生物活性多肽）和由该方法产生的产物的组合物的方法。 可以使用新颖的凝聚方法来实现改进的产品特性和容易的放大，其中在至少两个不同阶段向包含活性剂和聚合物的混合物中加入至少一种凝聚剂。

公开(公告)号：US20080171362A1

公开(公告)日：2008-07-17

申请号：US11781927

申请日：2007-07-23

Applicant: Girish Sahni ,  Rajesh Kumar ,  Chiati Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

Inventor： Girish Sahni ,  Rajesh Kumar ,  Chiati Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

IPC: C12P21/00 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12N1/21 ,  C12N1/19 ,  C12N1/15

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/3153 ,  C07K19/00 ,  C07K2319/70

Abstract: The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.

Abstract translation: 本发明提供编码具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质的多核苷酸，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。

公开(公告)号：US20080119569A1

公开(公告)日：2008-05-22

申请号：US11878160

申请日：2007-07-20

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Mark Fineman ,  Christine Smith ,  John Ong ,  David M. Lokensgard ,  Henry R. Costantino

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Mark Fineman ,  Christine Smith ,  John Ong ,  David M. Lokensgard ,  Henry R. Costantino

IPC: A61K47/00

CPC classification number: A61K47/34 ,  A61K9/0002 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/573 ,  A61K38/2278 ,  A61K38/26

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

公开(公告)号：US20070248022A1

公开(公告)日：2007-10-25

申请号：US11379312

申请日：2006-04-19

Applicant: Rajesh Kumar ,  Randall Ethier ,  Chelliah Sivachelvan ,  Robert Biskner

Inventor： Rajesh Kumar ,  Randall Ethier ,  Chelliah Sivachelvan ,  Robert Biskner

IPC: H04J1/16

CPC classification number: H04L41/5009 ,  H04L41/0604 ,  H04L43/00 ,  H04L43/06 ,  H04L43/0829 ,  H04L43/0852 ,  H04L43/087 ,  H04L43/16

Abstract: A method for alert throttling in media quality monitoring, includes monitoring a plurality of active communication sessions. Each active communication session is between at least two endpoints. The method also includes detecting at least one quality-impacted communication session out of the plurality of active communication sessions. The method also includes generating a first alert for each detected quality-impacted communication session out of the plurality of active communication sessions until a first throttling number of quality-impacted communication sessions is detected out of the plurality of active communication sessions. Upon detecting the first throttling number of quality-impacted communication sessions, the method includes generating a second alert for each group of additional second number of quality-impacted communication sessions detected out of the plurality of active communication sessions.

Abstract translation: 一种用于在媒体质量监测中进行警报节流的方法，包括监视多个主动通信会话。 每个活动通信会话在至少两个端点之间。 该方法还包括从多个主动通信会话中检测至少一个受质量影响的通信会话。 该方法还包括为多个活动通信会话中的每个检测到的受质量影响的通信会话生成第一警报，直到从多个主动通信会话中检测到受质量影响的通信会话的第一节流数量。 在检测到受质量影响的通信会话的第一节流数量时，该方法包括为从多个主动通信会话中检测到的对质量影响的通信会话的每组额外的第二数量生成第二警报。

公开(公告)号：US20070236850A1

公开(公告)日：2007-10-11

申请号：US11394810

申请日：2006-03-31

Applicant: Kelin Kuhn ,  Richard Hose ,  Edward Burton ,  Rajesh Kumar

Inventor： Kelin Kuhn ,  Richard Hose ,  Edward Burton ,  Rajesh Kumar

IPC: H02H3/22

CPC classification number: H01L27/088

Abstract: Power switch units for microelectronic devices are disclosed. In one aspect, a microelectronic device may include a functional circuit, and a power switch unit to switch power to the functional circuit on and off. The power switch unit may include a large number of transistors coupled together. The transistors may include predominantly positive-channel, insulated gate field effect transistors, which have a gate dielectric that includes a high dielectric constant material. Power switch units having such transistors may tend to have low power consumption. In an aspect, an overdrive voltage may be applied to the gates of such transistors to further reduce power consumption. Methods of overdriving such transistors and systems including such power switch units are also disclosed.

Abstract translation: 公开了用于微电子器件的功率开关单元。 一方面，微电子器件可以包括功能电路，以及电源开关单元，用于将功率电路接通和断开。 电源开关单元可以包括耦合在一起的大量晶体管。 晶体管可以包括主要为正沟道绝缘栅场效应晶体管，其具有包括高介电常数材料的栅极电介质。 具有这种晶体管的功率开关单元倾向于具有低功耗。 在一方面，可以将过驱动电压施加到这种晶体管的栅极，以进一步降低功耗。 还公开了过载驱动这种晶体管和包括这种功率开关单元的系统的方法。

公开(公告)号：US07250503B2

公开(公告)日：2007-07-31

申请号：US10631558

申请日：2003-07-31

Applicant: Girish Sahni ,  Rajesh Kumar ,  Chaiti Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

Inventor： Girish Sahni ,  Rajesh Kumar ,  Chaiti Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

IPC: C07H21/04 ,  C12N9/48 ,  C12P21/00 ,  C12P21/06

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/3153 ,  C07K19/00 ,  C07K2319/70

Abstract: The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.

Abstract translation: 本发明提供编码具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质的多核苷酸，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。