公开(公告)号：US20220145242A1

公开(公告)日：2022-05-12

申请号：US17430648

申请日：2021-03-25

Applicant: TOPPAN INC. ,  OSAKA UNIVERSITY

Inventor： Shiro KITANO ,  Shinji IRIE ,  Michiya MATSUSAKI

IPC: C12N5/00 ,  C07K14/78

Abstract: The present invention relates to an extracellular matrix-containing composition containing a fragmented extracellular matrix component and a compound bound or adsorbed to the fragmented extracellular matrix component.

公开(公告)号：US11324704B2

公开(公告)日：2022-05-10

申请号：US16082594

申请日：2017-03-06

Applicant: OSAKA UNIVERSITY ,  NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Hiroyuki Tanaka ,  Kiyoshi Okada ,  Hideki Yoshikawa ,  Koji Suzuki ,  Mitsuhiro Ebara

IPC: A61K9/70 ,  A61K47/34 ,  A61K47/36 ,  A61K31/714 ,  A61K35/36 ,  A61K45/00 ,  A61K38/18 ,  A61P25/02 ,  A61K47/32

Abstract: Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.

公开(公告)号：US20220133952A1

公开(公告)日：2022-05-05

申请号：US17502496

申请日：2021-10-15

Applicant: TOPPAN PRINTING CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Michiya MATSUSAKI ,  Shinji IRIE ,  Shiro KITANO

IPC: A61L27/24 ,  A61L27/44 ,  A61L27/54 ,  A61L31/04 ,  C12N5/00 ,  A61L27/38

Abstract: A method may comprises bringing cells suspended in an aqueous medium into contact with a plurality of fragmented collagen pieces and, after the cells brought into contact with the plurality of fragmented collagen pieces and the plurality of fragmented collagen pieces are concentrated, culturing the cells brought into contact with the fragmented collagen pieces, with the plurality of fragmented collagen pieces, to form a three-dimensional tissue.

公开(公告)号：US20220127218A1

公开(公告)日：2022-04-28

申请号：US17428127

申请日：2019-03-05

Applicant: OSAKA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Tomoo MIZUGAKI ,  Kiyotomi KANEDA ,  Yasuteru KAJIKAWA ,  Yuuichirou HIRAI

IPC: C07C67/317 ,  B01J23/652

Abstract: An object of the present invention is to provide a method for selectively producing a hydroxycarboxylic acid ester, the method including reducing a dicarboxylic acid monoester by means of a heterogeneous reaction. According to a method for producing a hydroxycarboxylic acid ester in an embodiment of the present invention, a hydroxycarboxylic acid ester represented by Formula (2) is produced by reducing a substrate dicarboxylic acid monoester represented by Formula (1) in the presence of a catalyst.
The catalyst comprises: metal species including M1 and M2; and a support supporting the metal species, and wherein M1 is rhodium, platinum, ruthenium, iridium or palladium; M2 is tin, vanadium, molybdenum, tungsten or rhenium; and the support is hydroxyapatite, fluorapatite, or hydrotalcite.

公开(公告)号：US11315595B2

公开(公告)日：2022-04-26

申请号：US17035077

申请日：2020-09-28

Applicant: THE UNIVERSITY OF TOKYO ,  OSAKA UNIVERSITY ,  FUJIFILM Corporation

Inventor： Shin-ichi Ohkoshi ,  Makoto Nakajima ,  Masashi Shirata ,  Hiroaki Doshita

IPC: G11B11/105 ,  G11B5/706 ,  G11B5/012

Abstract: The present invention provides a recording method and a recording device in which information can be easily recorded even in a magnetic recording medium using epsilon iron oxide particles having a high coercive force as a magnetic recording material. A recording device of the invention applies an external magnetic field H0 that inclines magnetization of epsilon iron oxide particles to a particle dispersion element containing epsilon iron oxide particles, and irradiates the particle dispersion element with light that excites the magnetization. Accordingly, the recording device is capable of inverting magnetization that is not capable of being inverted only by the external magnetic field, in accordance with a synergetic effect between the inclination of the magnetization and the light excitation of the magnetization.

公开(公告)号：US11309991B2

公开(公告)日：2022-04-19

申请号：US17230323

申请日：2021-04-14

Applicant: NEC CORPORATION ,  OSAKA UNIVERSITY ,  THE DOSHISHA

Inventor： Kazushi Muraoka ,  Naoto Ishii ,  Takumi Takahashi ,  Seiichi Sampei ,  Shinsuke Ibi

IPC: H04L1/00 ,  H03M13/11

Abstract: A BP detector of a wireless receiver apparatus reads a first parameter set or a second parameter set. The first parameter set includes a plurality of scaling factors and a plurality of damping factors learned together using a deep learning technique. The second parameter set includes a plurality of scaling factors and a plurality of node selection factors learned together using a deep learning technique from a memory. The BP detector executes an iterative BP algorithm that uses the first parameter set or the second parameter set in order to perform multi-user detection.

公开(公告)号：US20220113232A1

公开(公告)日：2022-04-14

申请号：US17268689

申请日：2019-08-13

Applicant: Osaka University

Inventor： Masahiro Kinooka

IPC: G01N1/38 ,  A01N1/02 ,  B01L3/02

Abstract: Provided is a distribution method with which particle components such as cells can be dispensed. In one aspect, provided is a method for distributing particles, the method including dispersing the particles in a plastic fluid, and dispensing the plastic fluid containing the particles. In another aspect, provided is a method for producing a product including a particle and a container for the particle, the method including dispensing a plastic fluid in which the particles are dispersed, from a storage part in which the plastic fluid is stored, to a plurality of the containers.

公开(公告)号：US20220099112A1

公开(公告)日：2022-03-31

申请号：US17547788

申请日：2021-12-10

Applicant: ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL ,  OSAKA UNIVERSITY

Inventor： Tomoyuki NODA ,  Yoshihiro NAKATA ,  Hiroshi ISHIGURO ,  Jun MORIMOTO

IPC: F15B15/08 ,  F15B15/14 ,  F15B21/08 ,  H02K33/16 ,  H02K41/03 ,  H02K7/20 ,  B25J19/00 ,  B25J11/00 ,  A61F2/70 ,  A61H3/00 ,  B25J9/00 ,  F15B15/12 ,  F15B15/20 ,  H02K41/035

Abstract: [Object] To provide a compact, high-output actuator device allowing force control.
[Solution] An actuator device 1000 includes an electromagnetic coil member 110 provided over a prescribed width on an outer circumference of a cylinder 100, and a movable element 200 slidable as a piston in the cylinder 100. The movable element 200 has a magnetic member 202, and is moved relatively by excitation of the electromagnetic coil member 110. Fluid is supplied to first and second chambers 106a and 106b such that when the movable element 200 is to be moved relatively, the movable element 200 is driven in the same direction.

公开(公告)号：US11249224B2

公开(公告)日：2022-02-15

申请号：US16938883

申请日：2020-07-24

Applicant: OSAKA UNIVERSITY

Inventor： Giichi Shibuya ,  Hiroyuki Yoshida ,  Masanori Ozaki

IPC: G02B3/08 ,  G02F1/1343 ,  G02B3/10 ,  G02F1/13 ,  G02C7/00 ,  G02F1/1333 ,  G02F1/1347 ,  G02F1/29 ,  G02F1/133 ,  G02C7/04 ,  G02F1/137

Abstract: A liquid crystal element (100) refracts and outputs light. The liquid crystal element (100) includes a first electrode (1), a second electrode (2), an insulating layer (21) that is an electric insulator, a resistance layer (22), a liquid crystal layer (23) including liquid crystal, and a third electrode (3). The insulating layer (21) is disposed between each location of the first and second electrodes (1) and (2) and the resistance layer (22) to insulate the first and second electrodes (1) and (2) from the resistance layer (22). The resistance layer (22) has an electrical resistivity higher than that of the first electrode (1) and lower than that of the insulating layer (21). The resistance layer (22) and the liquid crystal layer (23) are disposed between the insulating layer (21) and the third electrode (3). The resistance layer (22) is disposed between the insulating layer (21) and the liquid crystal layer (23). The insulating layer (21) has a thickness (ts) smaller than a thickness (th) of the resistance layer (22).

公开(公告)号：US11234995B2

公开(公告)日：2022-02-01

申请号：US16068163

申请日：2017-01-05

Applicant: OSAKA UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION

Inventor： Masayuki Nakamori ,  Hideki Mochizuki ,  Satoshi Obika ,  Takanori Yokota ,  Tetuya Nagata ,  Yuya Kasahara

IPC: C12N15/11 ,  A61K31/712 ,  C07K14/47 ,  C12N15/113 ,  C07H21/02 ,  C12N15/09 ,  A61P25/28 ,  A61P25/16

Abstract: The present invention can provide a nucleic acid medicine which has a higher effect and a more prolonged effect of inhibiting the expression of α-synudein can be provided. Disclosed is the oligonucleotide or a pharmacologically acceptable salt thereof, the oligonucleotide containing at least one nucleoside structure represented by Formula (I): (where each of Base and A are defined substituent or structure), can bind to an α-synudein gene, has activity for inhibiting expression of the α-synudein gene, and is complementary to the α-synudein gene, and the oligonucleotide has a length of twelve to twenty bases.