公开(公告)号：US20250104187A1

公开(公告)日：2025-03-27

申请号：US18977186

申请日：2024-12-11

Applicant: Leidos, Inc.

Inventor： Hanna Witzgall

IPC: G06T3/4046 ,  G06T7/194

Abstract: Object detection architectures for detecting and classifying objects in an image are modified to incorporate an extending Rapid Class Augmentation (XRCA) progressive learning algorithm with its defining aspect of memory built into its optimizer which allows joint optimization over both the old and the classes using just the new class data and eliminates the issues associated with catastrophic forgetting.

公开(公告)号：US20250077886A1

公开(公告)日：2025-03-06

申请号：US18815992

申请日：2024-08-27

Applicant: Leidos, Inc.

Inventor： Hanna Witzgall

IPC: G06N3/096 ,  G06N3/088

Abstract: An incremental learning algorithm, extending Rapid Class Augmentation (“XRCA”), implements an unconstrained, recursive least-squares (RLS) style of optimization that incorporates knowledge of all the past training examples into each optimization step by recursively computing an IFCM in a single multi-class prediction head. The single multi-class prediction head receives class token feature vectors from a pretrained, self-supervised transformer model and is able to achieve the same optimal performance as a non-incrementally trained classifier in a jointly optimal manner over a set of increasing classes.

公开(公告)号：US20250026446A1

公开(公告)日：2025-01-23

申请号：US18776307

申请日：2024-07-18

Applicant: Leidos, Inc.

Inventor： Levi Catton ,  Torsten Lau

IPC: B63B1/14

Abstract: A multihull vessel includes four main beam assemblies connected a central hull with two outer hulls and a deployment/retraction system which operates on the principle of converting transverse width of the beams into the longitudinal dimension, within the overall length of the vessel. An overall length of the multihull vessel is approximately the same when the four main beam assemblies are deployed and when four main beam assemblies are retracted.

公开(公告)号：US12205242B2

公开(公告)日：2025-01-21

申请号：US17840238

申请日：2022-06-14

Applicant: Leidos, Inc.

Inventor： Hanna Witzgall

IPC: G06T3/4046 ,  G06T7/194

Abstract: Object detection architectures for detecting and classifying objects in an image are modified to incorporate an extending Rapid Class Augmentation (XRCA) progressive learning algorithm with its defining aspect of memory built into its optimizer which allows joint optimization over both the old and the classes using just the new class data and eliminates the issues associated with catastrophic forgetting.

公开(公告)号：US12064753B2

公开(公告)日：2024-08-20

申请号：US16883425

申请日：2020-05-26

Applicant: The Research Foundation for The State University of New York ,  LEIDOS, Inc.

Inventor： Wayne E. Jones ,  Jian Liu ,  William E. Bernier ,  Julia B. Tollin ,  Danielle McCarthy ,  Emilly Obuya ,  Jared DeCoste

IPC: B01J23/42 ,  B01J21/06 ,  B01J23/06 ,  B01J31/16 ,  B01J31/38 ,  B01J35/39 ,  B01J35/61 ,  B01J37/08 ,  C02F1/32 ,  C02F1/72 ,  C04B35/622 ,  C04B35/624 ,  C04B35/626 ,  C04B35/628 ,  D01D5/00 ,  B01J35/23 ,  B01J35/58 ,  B01J37/03

CPC classification number: B01J31/38 ,  B01J21/063 ,  B01J23/06 ,  B01J23/42 ,  B01J31/1691 ,  B01J35/39 ,  B01J35/613 ,  B01J35/615 ,  B01J37/082 ,  B01J37/086 ,  C02F1/32 ,  C02F1/725 ,  C04B35/62259 ,  C04B35/624 ,  C04B35/62675 ,  C04B35/62844 ,  D01D5/003 ,  B01J35/23 ,  B01J35/58 ,  B01J37/036 ,  C02F2305/08 ,  C02F2305/10 ,  C04B2235/5264 ,  C04B2235/5409 ,  C04B2235/85 ,  Y02W10/37

Abstract: Mixed-phase TiO2 nanofibers prepared via a sol-gel technique followed by electrospinning and calcination are provided as photocatalysts. The calcination temperature is adjusted to control the rutile phase fraction in TiO2 nanofibers relative to the anatase phase. Post-calcined TiO2 nanofibers composed of 38 wt % rutile and 62 wt % anatase exhibited the highest initial rate constant of UV photocatalysis. This can be attributed to the combined influences of the fibers' specific surface areas and their phase compositions.

公开(公告)号：US20240233285A1

公开(公告)日：2024-07-11

申请号：US18403880

申请日：2024-01-04

Applicant: Leidos, Inc.

Inventor： John Blake Gage

IPC: G06T19/00 ,  G06F3/16 ,  G06T17/20 ,  H04L65/1089

CPC classification number: G06T19/006 ,  G06F3/167 ,  G06T17/20 ,  H04L65/1089

Abstract: A system for generating and providing an object in the field of view (FOV) of a user's augmented reality or virtual reality (AR/VR) session responsive to a verbal request for the object is described herein. An AR/VR communication component receives a verbal request for an object from the user and produces a text request for the object based on the verbal request. 2D image and 3D model generation components generate a 3D model of the object which is provided within the FOV of the user's AR/VR session.

公开(公告)号：US11639514B2

公开(公告)日：2023-05-02

申请号：US16846025

申请日：2020-04-10

Applicant: Leidos, Inc.

Inventor： John Dresios ,  Richard Holmes Griffey ,  Challise J. Sullivan ,  Erik D. Pendleton ,  Henri M. Sasmor ,  William L. Hicks ,  Eric M. Amendt

IPC: C12P21/00 ,  B01D15/34 ,  B01D15/36 ,  B01D15/38 ,  C12N9/12 ,  C07K14/505 ,  C07K14/535 ,  C12M1/40 ,  C12M1/00 ,  C12M1/36 ,  C12M3/00 ,  B01D15/12 ,  B01D15/10 ,  B01D15/14 ,  B01D15/22 ,  C12P21/02 ,  C12N1/06 ,  C12P21/06

Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements. Protein synthesis and purification modules are integrated into self-contained disposable fluidic cartridge that eliminates cross-contamination between runs. The platform allows for flexible production of protein biologics within 24 hours (from DNA to purified product).

公开(公告)号：US20220308202A1

公开(公告)日：2022-09-29

申请号：US17573346

申请日：2022-01-11

Applicant: Leidos, Inc.

Inventor： John R. Kendra

IPC: G01S13/90 ,  G01S13/46 ,  G01S13/58

Abstract: A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g. AUX and MOV systems) having differing velocity vectors. Referred to as Motion Extended Array Synthesis (MXAS), the resultant imaging system is comprised of the collection of baselines that are created between the two collection systems as a function of time. Because of the unequal velocity vectors, the process yields a continuum of baselines over some range, which constitutes an offset imaging system (OIS) in that the baselines engendered are similar to those for a real aperture of the same size as that swept out by the relative motion, but which are offset by some (potentially very large) distance.

公开(公告)号：US11407829B2

公开(公告)日：2022-08-09

申请号：US16879884

申请日：2020-05-21

Applicant: Leidos, Inc.

Inventor： Gabriel M. Gutierrez ,  Vinayaka Kotraiah ,  Timothy W. Phares ,  James Pannucci ,  Marc Mansour

IPC: A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C12N15/11 ,  A61K38/16 ,  C07K14/00 ,  A61K38/04 ,  C07K7/08

Abstract: This disclosure provides peptides which bind to LAG3, such as SAPWEPLHWPEDWWQGTGEW (SEQ ID NO:1), and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

公开(公告)号：US20220112243A1

公开(公告)日：2022-04-14

申请号：US17497069

申请日：2021-10-08

Applicant: Leidos, Inc.

Inventor： Gabriel M. Gutierrez ,  James Pannucci ,  Michael Ryan Weil ,  Timothy W. Phares ,  Vinayaka Kotraiah ,  Cecille D. Browne ,  Peter J. Buontempo

IPC: C07K7/08 ,  A61K38/10 ,  A61K45/06 ,  A61P35/00

Abstract: This disclosure provides peptides which can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.