公开(公告)号：US09937173B2

公开(公告)日：2018-04-10

申请号：US14767645

申请日：2014-02-14

Applicant: MCMASTER UNIVERSITY

Inventor： Waliul Khan ,  Gregory Steinberg ,  Palanivel Rengasamy

IPC: A61K31/505 ,  A61K31/7088 ,  A61K31/48 ,  A61K31/713 ,  C07K16/40

CPC classification number: A61K31/505 ,  A61K31/48 ,  A61K31/7088 ,  A61K31/713 ,  C07K16/40

Abstract: A method of treating obesity and obesity-related disorders in a mammal is provided. The method comprises the step of administering to the mammal a compound that inhibits the synthesis or activity of peripheral serotonin, including a Tph1 inhibitor or a serotonin receptor inhibitor.

公开(公告)号：US20180059100A1

公开(公告)日：2018-03-01

申请号：US15692006

申请日：2017-08-31

Applicant: McMaster University

Inventor： Abdel Rahman Abdel Fattah ,  Ahmed M. Abdalla ,  Fei Geng ,  Sarah Mishriki ,  Elvira Meleca ,  Ishwar K. Puri ,  Suvojit Ghosh

IPC: G01N33/543

CPC classification number: G01N33/5438 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54346 ,  G01N2333/4703

Abstract: A new magnetic carbon nanotube (mCNT) biosensor ink (mbio-ink) that utilizes immobilized capture agents to detect specific target analytes via a simple current response method is presented here, expanding the applications of magnetic carbon nanotubes as biomolecule-sensing nanomaterials. The employment of a magnetic field to print the mbio-ink into electrically conductive networks facilitates its integration with an external circuit via the use of a simple electrode system. When the sensor is connected to an external power source, the reduction in current, caused by an interaction between the capture agents and target analyte, is detected. The rapid detection technique and generic benchtop fabrication method allows for scale up, while the small volumes required and magnet independent electrical measurements renders the mbio-ink attractive for drug screening and disease detection applications.

公开(公告)号：US09842198B2

公开(公告)日：2017-12-12

申请号：US14405415

申请日：2013-06-05

Applicant: McMaster University

Inventor： Nathan Magarvey ,  Aubrey Bailey Morgan Wyatt ,  Chad William Johnston ,  Ashraf Ibrahim ,  Bin Ma ,  Lian Yang

IPC: G01N33/48 ,  G01N33/50 ,  G06F19/00 ,  G01N33/68 ,  C40B30/02 ,  G06F19/16 ,  G06F19/18 ,  C40B20/08 ,  G01N30/86 ,  G01N30/72

CPC classification number: G06F19/703 ,  C40B20/08 ,  C40B30/02 ,  G01N30/7233 ,  G01N30/86 ,  G01N33/6848 ,  G06F19/16 ,  G06F19/18

Abstract: The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures. Therefore the methods and systems of the present application represent an approach that is uniquely capable of navigating chemical space and providing a understanding of desired families and pharmacophores.

公开(公告)号：US20170214252A1

公开(公告)日：2017-07-27

申请号：US15406149

申请日：2017-01-13

Applicant: McMaster University

Inventor： Matthias Preindl ,  Ali Emadi

IPC: H02J7/00 ,  H02M3/04

CPC classification number: H02J7/0014 ,  H02J7/0018 ,  H02J7/345 ,  H02M3/04 ,  H02M3/24 ,  H02M2001/0074 ,  Y02B40/90 ,  Y02E70/40 ,  Y02T10/7055 ,  Y02T50/54

Abstract: The integration of the auxiliary power module (APM) functionality into non-dissipative balancing hardware of a high voltage battery or supercapacitor pack enables a more cost-effective non-dissipative balancing system while maintaining a similar complexity in topologies. The system uses state-space equations and three control problems to balance high-voltage energy storage elements and charge low voltage energy storage elements. Two optimization based controllers are employed to optimize both balancing and charging simultaneously.

公开(公告)号：US09486471B2

公开(公告)日：2016-11-08

申请号：US14461783

申请日：2014-08-18

Applicant: McMaster University

Inventor： Mickie Bhatia ,  Eleftherios Sachlos

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7068 ,  A61K31/5415 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7052

CPC classification number: A61K31/7068 ,  A61K31/5415 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K2300/00

Abstract: Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

Abstract translation: 描述了用于治疗癌症的方法和组合物，其包括多巴胺受体（DR）拮抗剂如硫利达嗪和化学治疗剂。 任选地，化学治疗剂是DNA合成抑制剂，例如阿糖胞苷或微管抑制剂如紫杉醇或多西他赛。 所述方法和组合物可用于治疗癌症如急性骨髓性白血病。

公开(公告)号：US20160289072A1

公开(公告)日：2016-10-06

申请号：US15091773

申请日：2016-04-06

Applicant: McMaster University

Inventor： Thomas A. Adams, II ,  Jaffer H. Ghouse

IPC: C01B3/38

CPC classification number: C01B3/48 ,  C01B3/384 ,  C01B2203/0233 ,  C01B2203/062 ,  C01B2203/0805

Abstract: A method of producing synthesis gas includes directing a first flow of hot synthesis gas through a first conduit, and directing a second flow of feed gas through at least one second conduit. The second conduit contains a reforming catalyst. The feed gas includes a mixture of steam and a hydrocarbon gas. The second conduit has an outer surface in contact with the hot synthesis gas. Heat from the hot synthesis gas is transferred across the second conduit to the feed gas thereby heating the feed gas and cooling the hot synthesis gas. The heated feed gas contacts the reforming catalyst and undergoes a reforming reaction that produces a third flow of synthesis gas.

Abstract translation: 一种生产合成气的方法包括引导热合成气的第一流通过第一导管，以及引导第二进料气流通过至少一个第二导管。 第二导管含有重整催化剂。 进料气体包括蒸汽和烃气体的混合物。 第二导管具有与热合成气接触的外表面。 来自热合成气体的热量通过第二导管传送到进料气体，从而加热进料气体并冷却热合成气。 加热的进料气体与重整催化剂接触并进行产生第三流合成气的重整反应。

公开(公告)号：US20160281167A1

公开(公告)日：2016-09-29

申请号：US15094086

申请日：2016-04-08

Applicant: MCMASTER UNIVERSITY

Inventor： Warren Foster ,  Nicholas Leyland ,  Jocelyne Wessels ,  Sanjay Agarwal

IPC: C12Q1/68 ,  G01N33/68 ,  C07K16/22

CPC classification number: C12Q1/6883 ,  C07K16/22 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2800/364 ,  G01N2800/52 ,  G01N2800/7095

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF and its receptor, Ntrk2, in a biological sample from the mammal, and determining that the mammal has endometriosis when the BDNF and Ntrk2 expression levels in the sample are elevated.

Abstract translation: 提供了用于诊断或监测哺乳动物子宫内膜异位症的方法。 所述方法包括确定来自哺乳动物的生物样品中BDNF及其受体Ntrk2的表达水平的步骤，并且当样品中的BDNF和Ntrk2表达水平升高时，确定哺乳动物具有子宫内膜异位症。

公开(公告)号：US20160236580A1

公开(公告)日：2016-08-18

申请号：US14939211

申请日：2015-11-12

Applicant: McMaster University

Inventor： Ruoyu Hou ,  Ali Emadi

IPC: B60L11/18

CPC classification number: B60L11/1811 ,  B60L11/1838 ,  B60L11/1868 ,  B60L2210/10 ,  B60L2270/147 ,  Y02T10/7005 ,  Y02T10/7022 ,  Y02T10/7216

Abstract: Various embodiments are described herein for a dual-voltage charging system for electrified vehicles. In one example embodiment, the dual-voltage charging system comprises an integrated active filter auxiliary power module (AFAPM) that applies the integrated AFAPM as an active power filter (APF) to compensate the low frequency harmonics in the high voltage (HV) battery charger when the HV battery is charging, and applies the integrated AFAPM as a low voltage (LV) battery charger auxiliary power module (APM) when the HV battery stops charging and starts to charge the LV battery.

Abstract translation: 本文描述了用于电气化车辆的双电压充电系统的各种实施例。 在一个示例实施例中，双电压充电系统包括集成有源滤波器辅助电源模块（AFAPM），其将集成AFAPM应用于有源电力滤波器（APF）以补偿高压（HV）电池充电器中的低频谐波 当HV电池充电时，当HV电池停止充电并开始对LV电池充电时，将集成AFAPM作为低压（LV）电池充电器辅助电源模块（APM）应用。

公开(公告)号：US20160113892A1

公开(公告)日：2016-04-28

申请号：US14977251

申请日：2015-12-21

Applicant: The Hospital for Sick Children ,  McMaster University

Inventor： Don J. Mahuran ,  Michael B. Tropak ,  Justin D. Buttner ,  Jan E. Blanchard ,  Eric D. Brown

IPC: A61K31/137

CPC classification number: A61K31/137 ,  A61K31/136 ,  A61K31/138 ,  A61K31/167 ,  A61K31/235 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5415 ,  A61K31/553 ,  A61K31/56 ,  A61K31/58 ,  A61K38/47 ,  A61K45/06 ,  C12Y302/01045

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract translation: 本文描述了治疗晚发型戈谢病的治疗组合物和方法。 该组合物包含具有作为β-葡糖脑苷脂酶突变体形式的药理学伴侣的活性的化合物。 治疗方法包括向有需要的受试者提供治疗有效量的此类组合物。

公开(公告)号：US20160106676A1

公开(公告)日：2016-04-21

申请号：US14886696

申请日：2015-10-19

Applicant: McMaster University

Inventor： Todd Hoare ,  Daryl Sivakumaran ,  Madeline Simpson ,  Eva Mueller

IPC: A61K9/16

CPC classification number: C08J3/075 ,  A61K9/5138 ,  C08J2333/06 ,  C08J2333/14 ,  C08J2333/26

Abstract: The present application relates to an aqueous method for the preparation of microgel particles using a stimuli-responsive prepolymer

Abstract translation: 本申请涉及使用刺激响应性预聚物制备微凝胶颗粒的水性方法