公开(公告)号：US12157778B2

公开(公告)日：2024-12-03

申请号：US17146009

申请日：2021-01-11

Applicant: The Regents of the University of California

Inventor： Wei Yao ,  Ruiwu Liu ,  Kit S. Lam ,  Wenwu Xiao ,  Nancy Lane

IPC: A61K38/07 ,  A61K31/663 ,  A61K47/64 ,  A61P19/10 ,  C07K5/103

Abstract: The present invention provides compounds and pharmaceutical compositions of peptidomimetic ligands. The peptidomimetic ligands can be conjugated with phosphonate drugs. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal stem cells and for the surface of bone.

公开(公告)号：US20240397475A1

公开(公告)日：2024-11-28

申请号：US18674658

申请日：2024-05-24

Applicant: The Regents of the University of California

Inventor： Li Xue ,  Katia Obraczka ,  Zouheir Rezki

IPC: H04W64/00 ,  H04W24/08

Abstract: The present disclosure relates to systems and methods for cross-layer device fingerprinting. A method is provided for efficiently fingerprinting networked devices, comprising, monitoring network communications of a plurality of electronic devices, extracting cross-layer features for each of the plurality of electronic devices, compiling the cross-layer features of each of the plurality of electronic devices into a device fingerprinting database, monitoring a network communication of an electronic device, extracting the cross-layer features from the network communication of the electronic device, classifying the electronic device into a device category using the cross-layer features and the device fingerprinting database, and performing a downstream network operation on the electronic device based on the device category. By extracting cross-layer features based on a downstream network operation, and pre-compiling the extracted features into a device fingerprinting database, a computational complexity of the device classification and downstream network operation may be reduced.

公开(公告)号：US20240393056A1

公开(公告)日：2024-11-28

申请号：US18262556

申请日：2022-01-27

Applicant: The Regents of the University of California ,  Carnegie Mellon University

Inventor： Vinod Narayanan ,  Erfan Rasouli ,  Anthony D. Rollett ,  Ines-Noelly T. Tano ,  Ziheng Wu ,  Sreedev Das ,  Nicholas Lamprinakos ,  Tracey L. Ziev ,  Parth Trilochan Vaishnav ,  Junwon Seo ,  Srujana Rao Yarasi

IPC: F28D9/00 ,  F28F9/02

Abstract: A high gravimetric and volumetric power density heat exchanger is provided for high-temperature and high-pressure applications with counter-flowing hot and cold agents that enter via respective inlet headers, transit parallel and adjacent flow passages, and exit via respective outlet headers. One or more headers for conveying one of the substances may be situated within the flow of the other substance. Structures within the flow passages promote the transfer of heat while limiting pressure drop on one or both sides. The structures may include microscale pins, an array of pins (with specified aspect ratios and spacing), a lattice of interconnected pins, parallel ridges, and/or other features. Through an additive manufacturing process, the headers are monolithically integrated into the heat exchanger instead of being separately constructed and attached.

公开(公告)号：US20240391980A1

公开(公告)日：2024-11-28

申请号：US18696922

申请日：2022-09-30

Applicant: The Regents of the University of California ,  Universidad Nacional Autónoma de México

Inventor： Rebecca Dubois ,  Lena Ricemeyer ,  Carlos F. Arias Ortiz ,  Tomás López Díaz ,  Rafaela Espinosa Organista

IPC: C07K16/10 ,  A61P31/14

Abstract: Provided are antibodies that specifically bind human astrovirus (HAstV) capsid spike protein. Fusion proteins and conjugates comprising such antibodies are also provided. Also provided are nucleic acids that encode one or both of the variable chain polypeptides of an antibody of the present disclosure, as are cells that include such nucleic acids. Also provided are compositions that include the antibodies of the present disclosure, including in some instances, pharmaceutical compositions. Methods of making and using the antibodies of the present disclosure are also provided. In certain aspects, provided are methods that include administering to an individual having or suspected of having a HAstV infection a therapeutically effective amount of an antibody, fusion protein or conjugate of the present disclosure.

公开(公告)号：US20240390511A1

公开(公告)日：2024-11-28

申请号：US18674612

申请日：2024-05-24

Applicant: The Regents of the University of California

Inventor： Dennis Slamon ,  Neil A. O'Brien

IPC: A61K47/68 ,  A61P35/00

Abstract: Described herein are methods for inhibiting a solid tumor expressing claudin-6 in a human subject, comprising administering to the human subject an effective amount of a composition comprising conjugates of a CLDN6-specific antigen-binding protein covalently bound to heterologous moieties comprising structural formula (I): wherein a first plurality of the conjugates are bound to four heterologous moieties comprising structural formula (I); at least about 95% of the first plurality of conjugates are structurally homogenous; and the effective amount is in a range of about 1.0 mg of conjugate/kg weight of the subject to 10 mg of conjugate/kg weight of the subject.

公开(公告)号：US12152174B2

公开(公告)日：2024-11-26

申请号：US18635583

申请日：2024-04-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Phillip B. Messersmith ,  Subhajit Pal ,  Kelsey G. Defrates ,  Jisoo Shin

IPC: C09J181/04 ,  A61L24/04 ,  C08G75/14 ,  C08G75/26

Abstract: Adhesive compositions for medical and non-medical uses are provided. The adhesive compositions can include cyclic disulfide monomers, oligomers of reactions between the cyclic disulfides, polymers of the cyclic disulfides, solid articles formed formed from the polymers, and any combination thereof. Methods of making, using, and recycling the adhesive compositions are provided, including use of the adhesive compositions on a variety of substrates that include biological tissue; biomaterials, including synthetics and natural such as bone, wood, and cellulosics; metals and alloys; polymers, plastics, and rubbers; ceramics; composites; and, any combination of these materials. The adhesives can adhere to substrates in a variety of environmental conditions that include ambient atmospheric conditions, wet conditions that include adhering materials underwater, and in a wide variety of temperatures and pressures, such as those temperatures and pressures found in medical environments, including in living tissue, as well as many residential, commercial, industrial, and manufacturing environments.

公开(公告)号：US20240384313A1

公开(公告)日：2024-11-21

申请号：US18676643

申请日：2024-05-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kyria Boundy-Mills ,  Luis Antonio Garay Almada ,  Irnayuli Rosaleida Sitepu ,  J. Bruce German ,  Tomas Cajka ,  Oliver Fiehn

IPC: C12P7/6436 ,  C07H15/04 ,  C12N1/14 ,  C12N1/16 ,  C12P19/44 ,  C12R1/645

Abstract: Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.

公开(公告)号：US12150381B2

公开(公告)日：2024-11-19

申请号：US17826455

申请日：2022-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Julia Schneider ,  Michael L. Chabinyc ,  Hengbin Wang ,  Hidenori Nakayama ,  Kyle D. Clark ,  Javier Read de Alaniz

IPC: H10K85/60 ,  B82Y30/00 ,  C07D487/12 ,  C07D487/16 ,  H01B1/04 ,  H10K30/30 ,  H10K85/20

Abstract: Triazabicylodecene can effectively n-dope a variety of organic semiconductors, including PCBM, thus increasing in-plane conductivities. We synthesized a series of TBD-based n-dopants via an N-alkylation reaction and studied the effect of various alkyl chains on the physical and device properties of the dopants. Combining two TBD moieties on a long alky chain gave a solid dopant, 2TBD-C10, with high thermal stability above 250° C. PCBM films doped by 2TBD-C10 were the most tolerant to thermal annealing and reached in-plane conductivities of 6.5×10−2 S/cm. Furthermore, incorporating 2TBD-C10 doped PCBM as the electron transport layer (ETL) in methylammonium lead triiodide (MAPbI3) based photovoltaics led to a 23% increase in performance, from 11.8% to 14.5% PCE.

公开(公告)号：US12148880B1

公开(公告)日：2024-11-19

申请号：US18650734

申请日：2024-04-30

Applicant: LG ENERGY SOLUTION, LTD. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ping Liu ,  Ke Zhou ,  Mengchen Liu ,  Jeong Woo Oh ,  Min-Sang Song

IPC: H01M10/0562 ,  H01M10/0525

Abstract: Solid electrolyte compositions and solid-state batteries are disclosed, which comprise a solid electrolyte layer including a sulfide-containing solid-state electrolyte material and a compound of Chemical Formula 1. The sulfide-containing solid-state electrolyte material includes but is not limited to Li6PS5Cl (“LPSC”), an LPS-based glass or glass ceramic of formula xLi2S·yP2S5, wherein x+y=1, or an argyrodite-based sulfide-based solid electrolyte or formula Li6PS5X, wherein X=Cl, Br, or I) or Li6−yPS5−yCl1+y, where y is

公开(公告)号：US12144843B2

公开(公告)日：2024-11-19

申请号：US16928724

申请日：2020-07-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： B. Chia Soo ,  Kang Ting ,  Zhong Zheng

IPC: A61K38/18 ,  A61K38/17

Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof.