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    ENCAPSULATED VALVE SYSTEM AND METHOD OF USE
    141.
    发明申请
    ENCAPSULATED VALVE SYSTEM AND METHOD OF USE 有权

    公开(公告)号：US20210254729A1

    公开(公告)日：2021-08-19

    申请号：US17306513

    申请日：2021-05-03

    Applicant: Repligen Corporation

    Inventor： Michael C. Gagne ,  Steven V. Cates

    IPC: F16K7/04 ,  F16K7/07 ,  F16K27/00 ,  F16K7/06 ,  F16K11/02 ,  F16K11/10 ,  F16K3/30

    Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.

    Methods, devices and systems for 3-stage filtration
    143.
    发明授权
    Methods, devices and systems for 3-stage filtration 有权

    公开(公告)号：US11028124B2

    公开(公告)日：2021-06-08

    申请号：US15972442

    申请日：2018-05-07

    Applicant: REPLIGEN CORPORATION

    Inventor： Michael Bransby

    IPC: C07K1/36 ,  B01D63/02 ,  B01D69/08

    Abstract: The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.

    Encapsulated valve system and method of use
    144.
    发明授权
    Encapsulated valve system and method of use 有权

    公开(公告)号：US11022223B2

    公开(公告)日：2021-06-01

    申请号：US16267997

    申请日：2019-02-05

    Applicant: REPLIGEN CORPORATION

    Inventor： Michael C. Gagne ,  Steven V. Cates

    IPC: F16K7/04 ,  F16K7/07 ,  F16K27/00 ,  F16K7/06 ,  F16K11/02 ,  F16K11/10 ,  F16K3/30

    Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.

    METHOD OF ACTUATION OF AN ALTERNATING TANGENTIAL FLOW DIAPHRAGM PUMP
    148.
    发明申请
    METHOD OF ACTUATION OF AN ALTERNATING TANGENTIAL FLOW DIAPHRAGM PUMP 审中-公开

    公开(公告)号：US20200377839A1

    公开(公告)日：2020-12-03

    申请号：US16908225

    申请日：2020-06-22

    Applicant: Repligen Corporation

    Inventor： Rudolf Pavlik

    IPC: C12M1/00 ,  F04B49/20 ,  F04B43/02 ,  F04B43/06 ,  C12M1/34 ,  F04B23/04 ,  C12M1/36 ,  F04B43/073 ,  F04B43/00 ,  F04B49/06

    Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.

    Method for Proliferation of Cells Within a Bioreactor Using a Disposable Pumphead and Filter Assembly
    149.
    发明申请
    Method for Proliferation of Cells Within a Bioreactor Using a Disposable Pumphead and Filter Assembly 审中-公开

    公开(公告)号：US20200325437A1

    公开(公告)日：2020-10-15

    申请号：US16912859

    申请日：2020-06-26

    Applicant: REPLIGEN CORPORATION

    Inventor： David Serway

    IPC: C12M1/00 ,  C12Q3/00 ,  C12N1/02

    Abstract: A method for promoting biological activity uses a filter system to increase cell production of a fed batch bioreactor. The filter system cycles bioreactor fluid through a hollow fiber tangential flow filter which separates metabolic wastes (as well as proteins) from cells produced in bioreactor and returned to fed batch bioreactor, improving cell production in the fed batch bioreactor. The filter system includes a disposable pump and filter, and a reusable control system. The pump is a low shear gamma stable pump gently cycling bioreactor fluid through the filter with minimal damage to the cells produced in the bioreactor. The pumphead and hollow fiber tangential flow filter are disposable. The pump motor is part of the control system and is reusable. The pumphead and filter are provided as an assembled and pre-sterilized unit allowing simple and quick attachment to the fed batch bioreactor, and simple and quick disposal.

    Method of actuation of an alternating tangential flow diaphragm pump
    150.
    发明授权
    Method of actuation of an alternating tangential flow diaphragm pump 有权

    公开(公告)号：US10774297B2

    公开(公告)日：2020-09-15

    申请号：US15892214

    申请日：2018-02-08

    Applicant: Repligen Corporation

    Inventor： Rudolf Pavlik

    IPC: C12M1/00 ,  F04B49/20 ,  F04B43/02 ,  F04B43/06 ,  C12M1/34 ,  F04B23/04 ,  C12M1/36 ,  F04B43/073 ,  F04B43/00 ,  F04B49/06

    Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.

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