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    Implantable enzyme-based monitoring systems adapted for long term use
    141.
    发明授权
    Implantable enzyme-based monitoring systems adapted for long term use 失效
    适用于长期使用的基于植入式酶的监测系统

    公开(公告)号：US6081736A

    公开(公告)日：2000-06-27

    申请号：US953817

    申请日：1997-10-20

    申请人： Michael S. Colvin ,  Joseph H. Schulman ,  Lyle Dean Canfield ,  Rajiv Shah

    发明人： Michael S. Colvin ,  Joseph H. Schulman ,  Lyle Dean Canfield ,  Rajiv Shah

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14865 ,  A61B5/0031

    摘要： Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used. In a further embodiment, the monitoring systems use enzyme and electrolyte reservoir bulbs in fluid communication with the enzyme and electrolyte reservoirs, respectively, and positioned near the skin surface, thereby providing ready access to the enzyme and electrolyte solutions without the need for explantation of the device. Further provided herein is an enzyme solution including microspheres in association with the enzyme; whereby the enzyme is immobilized by the microspheres and the microspheres are in a fluid, flowable solution. Also provided herein is a method of extending the useful life of an implantable enzyme-based monitoring system, which method includes providing means, within the system, to replenish the enzyme and/or electrolyte solution.

    摘要翻译： 本文描述了适于长期体内使用的改进的可植入监测系统以测量一种或多种规定物质如葡萄糖的浓度。 特别地，描述了可植入酶的葡萄糖监测系统，其包括以下至少一个：用于在酶反应消耗的时候补充酶溶液的装置; 用于补充洗涤电极组件的电解液的装置; 并且微处理装置近似于电极组件。 在优选实施例中，微处理器组件与固定电极组件的基底密封相关。 此外，监测系统采用与酶和电解质室流体连通的一个或多个储存器系统，其中使用酶和电解质溶液。 在另一个实施方案中，监测系统使用分别与酶和电解质储存器流体连通并且定位在皮肤表面附近的酶和电解质储存器灯泡，从而提供对酶和电解质溶液的准备进入，而不需要移除 设备。 本文还提供了包含与酶结合的微球的酶溶液; 由此通过微球固定酶，并且微球体处于流动的可流动溶液中。 本文还提供了延长可植入酶的监测系统的使用寿命的方法，该方法包括在系统内提供补充酶和/或电解质溶液的装置。

    Layered enzyme compositions for use with analyte sensors
    148.
    发明授权
    Layered enzyme compositions for use with analyte sensors 有权
    用于分析物传感器的分层酶组合物

    公开(公告)号：US08608921B2

    公开(公告)日：2013-12-17

    申请号：US13010640

    申请日：2011-01-20

    申请人： Xiaolong Li ,  Rajiv Shah ,  Qingling Yang ,  Yiwen Li ,  Barry Phong Pham

    发明人： Xiaolong Li ,  Rajiv Shah ,  Qingling Yang ,  Yiwen Li ,  Barry Phong Pham

    IPC分类号： G01N27/327 ,  G01N27/416

    CPC分类号： C12Q1/00 ,  C12Q1/005 ,  C12Q1/006

    摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

    摘要翻译： 本发明的实施例提供具有优化元件的电流分析传感器，例如由溅射的铂组合物形成的电极以及被选择用于优化各种传感器元件和传感器的特性的材料层。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。