公开(公告)号：US11192070B2

公开(公告)日：2021-12-07

申请号：US16862137

申请日：2020-04-29

Applicant: EMD Millipore Corporation

Inventor： Salvatore Giglia ,  David Nhiem

IPC: B01D65/10 ,  G01N15/08

Abstract: A method of integrity testing a porous material is disclosed, providing a porous material suitable for filtration to be tested, said porous material having a first surface and a second surface; wetting said porous material with a wetting liquid; providing a gas stream comprising at least first and second gases humidified with said wetting liquid below the saturation vapor pressure of said wetting liquid and wherein said humidified gas stream has a humidity of 50-99%; introducing said gas stream to said first surface of said porous material; causing said first and second gases to flow through said porous material; measuring the concentration of at least one of said first and second gases in the permeate stream exiting said second surface of said porous material; and comparing the measured concentration to a predetermined concentration.

公开(公告)号：US20210355606A1

公开(公告)日：2021-11-18

申请号：US17290024

申请日：2019-10-31

Applicant: EMD Millipore Corporation

Inventor： Onur Y. Kas ,  Thang Nguyen ,  Nitin Satav ,  Martin Cuddy

IPC: D01D5/00 ,  D04H1/728

Abstract: Provided herein are electrospirming apparatuses and methods for efficient production of nanofiber structures.

公开(公告)号：US20210260504A1

公开(公告)日：2021-08-26

申请号：US17315721

申请日：2021-05-10

Applicant: EMD Millipore Corporation

Inventor： Jonathan Steen ,  Mikhail Kozlov ,  Herbert Lutz ,  Joseph Parrella ,  Elizabeth M. Goodrich ,  Bala Raghunath

IPC: B01D29/90 ,  B01D61/14 ,  B01D63/08 ,  B01D29/52 ,  B01D29/60

Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

公开(公告)号：USD928947S1

公开(公告)日：2021-08-24

申请号：US29662885

申请日：2018-09-10

Applicant: EMD Millipore Corporation

Designer： John Gugliotti

公开(公告)号：US20210253994A1

公开(公告)日：2021-08-19

申请号：US17262957

申请日：2019-05-15

Applicant: EMD Millipore Corporation

Inventor： Laurent Jourdainne ,  Sebastien Cirou

IPC: C12M1/34 ,  C12M1/12 ,  C12M3/00

Abstract: The invention concerns an installation for treating biological liquid by viral inactivation, comprising a main supply valve (4) for suppling biological liquid to treat, a first line (2) downstream of said valve and provided with a first main tank (7), a second line (3) downstream of said valve and provided with a second main tank (14), said second line being in parallel with said first line, and a third main tank (11) disposed at an outlet both from said first line and said second line and configured to be successively supplied by said first main tank and by said second main tank; said installation being configured such that in each of said first, second and third main treatment tanks, a determined volume of acid and a determined volume of base are introduced at least so as to adjust a pH of said biological liquid and to regulate a rate of drainage flow of said third main treatment tank so as to provide a continuous rate of flow of treated biological liquid at an outlet from said installation.

公开(公告)号：US11040310B2

公开(公告)日：2021-06-22

申请号：US16207895

申请日：2018-12-03

Applicant: EMD Millipore Corporation

Inventor： Herbert Lutz ,  Joseph Parrella ,  Bala Raghunath

IPC: B01D61/14 ,  B01D61/18 ,  B01D63/08 ,  B01D65/02 ,  C07K1/34

Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

公开(公告)号：US11014129B2

公开(公告)日：2021-05-25

申请号：US14912440

申请日：2014-06-19

Applicant: EMD Millipore Corporation

Inventor： Nanying Bian ,  Sapna Mehtani ,  John Dana Hubbard

IPC: B08B9/027 ,  C07K1/22 ,  A61L2/18 ,  B08B3/08

Abstract: The present invention provides methods for cleaning a Protein A chromatography column employing a media comprising a Protein A ligand derived from the C domain of Staphylococcus aureus, such that the column can be cleaned using both acidic and alkaline solutions.

公开(公告)号：US10793593B2

公开(公告)日：2020-10-06

申请号：US13732613

申请日：2013-01-02

Applicant: EMD Millipore Corporation

Inventor： Wilson Moya

IPC: C07K1/36 ,  C07K1/32 ,  C07K1/30 ,  C07K16/00

Abstract: The present invention relates to a selectively soluble polymer capable of binding to one or more constituents in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and is rendered insoluble and precipitates out of solution upon a change in the process conditions. While in its solubilized state, the polymer is capable of binding to a selected entity within the stream such as impurities (DNA, RNA, host cell protein, endotoxins, etc.) in a cell broth and remains capable of binding to that entity even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered and further processed.

公开(公告)号：US10605738B2

公开(公告)日：2020-03-31

申请号：US12584807

申请日：2009-09-11

Applicant: Gael Waiche

Inventor： Gael Waiche

IPC: G01N21/64 ,  G01N21/76 ,  G01N33/58 ,  C12Q1/04

Abstract: The device for the microbiological analysis of a support adapted to contain microorganisms marked by a fluorophore agent, said agent being adapted to absorb light energy with an absorption spectrum (53) having a crest (53′) at a predetermined absorption wavelength (λ2) and to release that energy by emitting light with an emission spectrum (54) having a crest (54′) at a predetermined emission wavelength (λ3) distinct from said absorption wavelength (λ2), comprises illuminating means; the spectrum (55) of the excitation light coming from the illuminating means having a crest (55′) at a predetermined excitation wavelength (λ1) with a predetermined difference between the excitation (λ1) and absorption (λ2) wavelengths by virtue of which it is made easy to discriminate the light emitted by said fluorophore agent from that coming from the illuminating means.

公开(公告)号：US10422748B2

公开(公告)日：2019-09-24

申请号：US12584806

申请日：2009-09-11

Applicant: Gael Waiche ,  Sebastien Ribault

Inventor： Gael Waiche ,  Sebastien Ribault

IPC: G01N21/64

Abstract: The device for the microbiological analysis of a support (41) adapted to contain microorganisms marked by a fluorophore agent comprises illuminating means adapted to illuminate said support (41) comprising two bases (21) on each of which is mounted at least one group of light sources (22), with said sources (22) of that group being regularly spaced from each other to form an array for illuminating said support (41), said bases (21) being fixed to a frame of said device, one on each side of an opening (9) formed in said frame, with said bases (21) being inclined towards each other in the direction of a predetermined location for reception of said support (41) in said device.