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公开(公告)号:US20220088585A1
公开(公告)日:2022-03-24
申请号:US17117131
申请日:2020-12-10
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Joonseok LEE , Inae LEE
Abstract: A test strip may include a porous sampling pad through which the air passes to collect a specimen, a conjugation pad which is positioned on a supporter in contact with the sampling pad, and in which a plurality of capture agent-nanoparticle composites specifically binding to a target material are dispensed, a membrane which is positioned on the supporter in contact with the conjugation pad, and includes a test line to which the capture agent-nanoparticle composites to which the target material binds are conjugated when the specimen moves and a control line to which the capture agent-nanoparticle composites are conjugated, and an absorption pad configured to absorb the moving specimen on the supporter.
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公开(公告)号:US20220087947A1
公开(公告)日:2022-03-24
申请号:US17384913
申请日:2021-07-26
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Hyojin LEE , Seongchan KIM , Youngdo JEONG
Abstract: Provided are a surface-aminated mesoporous silica nanoparticle, a method of preparing the same, use of the nanoparticle for delivering a ribonucleoprotein, and use of the nanoparticle for the prevention or treatment of cancer. The surface-aminated mesoporous silica nanoparticle may be loaded with large RNPs such as Cas9-RNP, and thus may be applied to treatment of various diseases treatable by gene editing.
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143.
公开(公告)号:US11280781B2
公开(公告)日:2022-03-22
申请号:US16587062
申请日:2019-09-30
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Soo Hyun Lee , Nakwon Choi , Byung Chul Lee , Hyungbeen Lee , Mintack Oh
IPC: G01N33/543 , C12M1/00 , G01N29/02 , C12N15/10
Abstract: The present disclosure relates to an apparatus and a method for extracting genome, capable of acquiring a sufficient amount of genome for genetic analysis with high extraction efficiency, even with a small amount of target sample.
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144.
公开(公告)号:US11278365B2
公开(公告)日:2022-03-22
申请号:US16711434
申请日:2019-12-12
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Keri Kim , Seong Il Kwon , Jeongryul Kim
IPC: A61B34/00
Abstract: An articulating structure that bends by relative movement of a plurality of segments connected in series, includes a first segment and a second segment arranged in contact with each other, wherein the first segment has a first front rolling contact surface, and the second segment has a second rear rolling contact surface in line contact with the first front rolling contact surface on a first direction contact line, the first segment has a projection protruding forward from the first front rolling contact surface, and the second segment has a coupling element recessed in the second rear rolling contact surface, wherein the projection is inserted into the coupling element, the first segment and the second segment make a relative rolling movement for translation of the first direction contact line while maintaining the line contact, and the projection supports the first segment and the second segment for the first direction.
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公开(公告)号:US11273192B2
公开(公告)日:2022-03-15
申请号:US16428626
申请日:2019-05-31
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Jungyeob Ham , Taejung Kim , Young Tae Park , Kyusun Kim , Pilju Choi , Seon-Jun Choi , Bong Geun Song , Jae Young Choi
IPC: A61K36/258 , A23L33/105 , A61K8/9789 , A61K31/704 , A61Q19/08 , A61K8/63
Abstract: Provided are a method of efficiently producing a ginseng leaf extract including rare ginsenosides Rg6, Rk3, and Rh4 in increased amounts, and use of a ginseng leaf extract produced by the method.
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公开(公告)号:US20210394161A1
公开(公告)日:2021-12-23
申请号:US17271206
申请日:2019-11-06
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Sukang BAE , Seoung-Ki LEE , Dae-Young JEON , Myung Jong KIM , Nam Dong KIM
IPC: B01J23/755 , B01J21/18 , B01J23/745 , B01J23/75 , B01J23/46 , B01J21/02 , B01J27/02 , B01J27/14 , B01J37/02
Abstract: Provided is a method for manufacturing a single-atom catalyst supported on a carbon support, including treating a mixture of a precursor of a carbon support and a precursor of a hetero element other than carbon through a dry vapor phase process, thereby supporting, on a carbon support, a single-atom catalyst containing a hetero element other than carbon.
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公开(公告)号:US20210393860A1
公开(公告)日:2021-12-23
申请号:US17336321
申请日:2021-06-02
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Joonseok LEE , Eunyoung JEON
Abstract: Provided are a method of manufacturing a stent for drug release that may be coated with a drug by forming a 3D nanostructured film on the surface of a stent and a stent for drug release manufactured thereby, more particularly, a method of manufacturing a stent for drug release including: (a) preparing a stent, (b) forming a 3D nanostructured film on a surface of the stent; and (c) surface-treating the 3D nanostructured film, and a stent for drug release manufactured thereby.
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公开(公告)号:US20210371742A1
公开(公告)日:2021-12-02
申请号:US17319095
申请日:2021-05-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Seung Hee HAN , Sung Ju HAN , Min SEO , Min Gyeong CHO
Abstract: The present invention relates to a fluorescent nanodiamond preparing method including a first operation of preparing nanodiamonds having an average particle diameter of 10 nm or less, a second operation of implanting plasma ions into the nanodiamonds, a third operation of heat-treating the nanodiamonds implanted with the plasma ions under a vacuum or inert gas atmosphere, a fourth operation of oxygen treatment of the heat-treated nanodiamonds under a gas atmosphere including oxygen to oxidize the surfaces of the nanodiamonds, a fifth operation of acid-treating the oxygen-treated nanodiamonds, a sixth operation of centrifuging and cleaning the acid-treated nanodiamonds, and a seventh operation of drying the cleaned nanodiamonds, wherein, in the second operation, the plasma ions are implanted at an incident ion dose of 1013 ions/cm2 or more and 1020 ions/cm2 or less.
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公开(公告)号:US20210371515A1
公开(公告)日:2021-12-02
申请号:US16771918
申请日:2020-03-10
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , THE ASAN FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
Inventor: Mihue JANG , Eunsung JUN , Anna JU
IPC: C07K16/28 , C12N5/0783 , C07K14/705 , C07K14/725 , A61P35/00 , C12N15/86 , A61K35/17
Abstract: Provided are a genetically modified immunocyte expressing a chimeric antigen receptor (CAR) comprising an antigen binding domain specifically binding to cancer cells and/or expressing TRAIL, a composition for preventing or treating cancer, the composition comprising the immunocytes, a cell therapeutic agent, a method of providing information for cancer diagnosis, and a method of preparing the genetically modified immunocyte.
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公开(公告)号:US20210370393A1
公开(公告)日:2021-12-02
申请号:US16921254
申请日:2020-07-06
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Ji Won LEE , Soo Yeol PHYO , Sun CHOI , Sung CHOI
Abstract: Embodiments of the present disclosure provide a method of manufacturing a metal column using 3D printing technology. The method of manufacturing a metal column includes steps of: creasing a 3D-CAD design for printing the metal column; printing the metal column; pretreating the inner surface of a channel inside the metal column at low temperature; and coating the inner surface of the channel with a stationary phase so that the metal column is capable of separating a gas mixture into components.
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