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    Process for preparing nitrooxyderivative of naproxen
    141.
    发明申请
    Process for preparing nitrooxyderivative of naproxen 失效
    制备萘普生硝基氧化酶的方法

    公开(公告)号：US20060173005A1

    公开(公告)日：2006-08-03

    申请号：US10523722

    申请日：2003-08-06

    Applicant: Piero Del Soldato ,  Giancarlo Santus ,  Francesca Benedini

    Inventor： Piero Del Soldato ,  Giancarlo Santus ,  Francesca Benedini

    IPC: A61K31/537 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/445 ,  A61K31/44 ,  A61K31/50

    CPC classification number: C07C269/06 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C203/04 ,  C07C271/28 ,  C07C303/28 ,  C07C309/73

    Abstract: The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of naproxen or bromonaproxen and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ   (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.

    Abstract translation: 本发明涉及制备通式（A）化合物的方法，如说明书中所报导的，其中R是萘普生或溴苯丙酮的基团，R 1 -R 12， / SUB>为氢或烷基，m，n，o，q，r和s各自独立地为0至6的整数，p为0或1，X为O，S，SO，SO NR 2，NR 13或PR 13或芳基杂芳基，所述方法包括使式（B）化合物<？in-line-formula description =“在线式 “end =”lead“？> R-COOZ（B）<？in-line-formula description =”In-line Formulas“end =”tail“？>其中R如上所定义，Z是氢或选择阳离子 其中R1-R12和m，n，o，p，q，r，s分别为：Li +，Na +，K +，Ca ++，Mg ++，四烷基铵，四烷基鏻与式（C） 如上所定义，Y是合适的离去基团。

    Method of synthesizing diglycerol tetranitrate, and solid rocket motor propellant containing the same
    143.
    发明申请
    Method of synthesizing diglycerol tetranitrate, and solid rocket motor propellant containing the same 审中-公开
    合成二甘油四硝酸酯的方法，以及含有其的固体火箭发动机推进剂

    公开(公告)号：US20030089435A1

    公开(公告)日：2003-05-15

    申请号：US09803235

    申请日：2001-03-09

    Inventor： Andrew J. Sanderson ,  Laura J. Martins

    IPC: C06B045/10

    CPC classification number: C06B45/105 ,  C07C201/02 ,  C07C203/04

    Abstract: Diglyercol tetranitrate is an energetic nitrate ester plasticizer having no freezing point, making the nitrate ester plasticizer especially suited for use in solid rocket motor propellants that are subjected to low temperature storage and operational environments, which can reach as low as null54null C. in temperature. In order to avoid problems associated with fume-off that characterize the conventional synthesis method of making diglycerol tetranitrate, synthesis is performed in a medium including a mixed acid phase and an inert organic phase. The mixed acid phase contains, as ingredients, at least one nitronium ion source and at least one acid having sufficient strength to generate nitronium ions from the nitronium ion source. The nitronium ions in the mixed acid nitrate diglycerol to form diglycerol tetranitrate, which is then received into the organic liquid. The organic liquid, which preferably is a chlorocarbon such as dichloromethane, is insoluble with diglycerol but soluble with diglycerol tetranitrate. The inert organic phase is then treated to neutralize any acid contained in the inert organic phase, and the diglycerol tetranitrate is separated from the inert organic phase.

    Abstract translation: 四氢硝酸二甘油酯是一种不含冰点的高能硝酸酯增塑剂，使得硝酸酯增塑剂特别适用于经受低温储存和操作环境的固体火箭发动机推进剂，其可达到低至-54℃ 温度。 为了避免与制备二甘油四硝酸酯的常规合成方法相关的烟气相关的问题，在包括混合酸相和惰性有机相的介质中进行合成。 混合酸相含有至少一种硝鎓离子源和至少一种具有足够强度以从硝鎓离子源产生硝鎓离子的酸。 混合酸硝酸二甘油中的硝鎓离子形成二甘油四硝酸酯，然后将其接收到有机液体中。 优选氯代烃如二氯甲烷的有机液体不溶于二甘油，但可与二甘油四硝酸盐溶解。 然后处理惰性有机相以中和惰性有机相中所含的任何酸，并将二甘油四硝酸酯与惰性有机相分离。

    Continuous closed loop nitration of polyhydric alcohols
    146.
    发明授权
    Continuous closed loop nitration of polyhydric alcohols 失效
    多元醇的连续闭环硝化

    公开(公告)号：US4251455A

    公开(公告)日：1981-02-17

    申请号：US35754

    申请日：1979-05-03

    Applicant: Hans-Jurgen Gebauer

    Inventor： Hans-Jurgen Gebauer

    IPC: C07C201/02 ,  C07C77/02

    CPC classification number: C07C201/02

    Abstract: A process for the continuous manufacture of a nitric acid ester of a polyhydric alcohol by reacting the polyhydric alcohol with nitrating acid, comprising circulating a stream of waste nitrating acid through a closed loop, injecting nitrosulphuric acid into said circulating stream, cooling the stream downstream of the injection, feeding the alcohol via a mixer into the cooled stream, cooling the stream to remove heat produced by reaction, and separating nitrated polyhydric alcohol from the loop, along with sufficient waste acid to keep the volume in the loop substantially constant, circulation being carried out at a rate such that the average residence time of waste acid in the loop is less than about 15 minutes, preferably about 2 to 5 minutes. This avoids the prolonged storage of large quantities of waste acid which is inherently dangerous. When the system is to be shut down all the circulating waste acid can be replaced by fresh nitrosulphuric acid, relatively small in volume.

    Abstract translation: 一种通过使多元醇与硝酸反应来连续制造多元醇硝酸酯的方法，其包括使废硝酸酸流循环通过闭环，将亚硝基硫酸注入所述循环流中，冷却流 注射，通过混合器将醇进料到冷却的流中，冷却流以除去由反应产生的热量，并将硝化的多元醇与环分离，以及足够的废酸以保持循环中的体积基本上恒定，循环为 以使得循环中废酸的平均停留时间小于约15分钟，优选约2至5分钟的速率进行。 这避免了长期储存大量本来危险的废酸。 当系统关闭时，所有的循环废酸可以用新鲜的亚硫酸替代，体积相对较小。

    Reprocessing of final acid from nitroglycerine production
    148.
    发明授权
    Reprocessing of final acid from nitroglycerine production 失效
    从硝酸甘油生产中回收最终酸

    公开(公告)号：US3975452A

    公开(公告)日：1976-08-17

    申请号：US483757

    申请日：1974-06-27

    Applicant: Hans Rolf Jakob Mayer ,  Gerhard Langecker ,  Hans-Jurgen Gebauer

    Inventor： Hans Rolf Jakob Mayer ,  Gerhard Langecker ,  Hans-Jurgen Gebauer

    IPC: C06B21/00 ,  C07C79/10

    CPC classification number: C07C201/02 ,  C06B21/0091

    Abstract: A process for treating final acid obtained in forming a nitrate of a polyhydric alcohol, said final acid comprising a mixture of sulfuric acid, nitric acid, water and said nitrate, said process comprising mixing said final acid with an aromatic nitro compound, allowing said mixture to stratify whereby said nitrate is dissolved into said aromatic nitro compound as one layer and there is another substantially nitrate-free waste acid layer comprising sulfuric acid, nitric acid and water, and separating said layers. Preferably the nitrate is trinitroglycerine and the aromatic nitro compound is dinitrotoluene. The waste acid layer advantageously is partially used to form additional dinitrotoluene and is partially mixed with fresh final acid since its presence serves to stabilize such final acid by preventing any settling out of trinitroglycerine, presumably by the action of the small amount of dinitrotoluene which may be present in said waste acid.

    Abstract translation: 一种处理在形成多元醇的硝酸盐中获得的最终酸的方法，所述最终的酸包括硫酸，硝酸，水和所述硝酸盐的混合物，所述方法包括将所述最终酸与芳族硝基化合物混合，使所述混合物 分层，其中所述硝酸盐作为一层溶解到所述芳族硝基化合物中，并且存在包含硫酸，硝酸和水的另外基本上无硝酸盐的废酸层，并分离所述层。 优选地，硝酸盐是三硝基甘油，芳族硝基化合物是二硝基甲苯。 废酸层有利地部分用于形成额外的二硝基甲苯，并且与新鲜的最终酸部分混合，因为其存在用于通过防止任何沉淀三硝基甘油来稳定这种最终酸，这可能是通过少量的二硝基甲苯的作用 存在于所述废酸中。

    Process for preparing nitric acid esters of 1,1,2,2-tetrahydro-perfluoro-alkanols
    149.
    发明授权
    Process for preparing nitric acid esters of 1,1,2,2-tetrahydro-perfluoro-alkanols 失效
    制备1,1,2,2-四氢 - 全氟 - 链烷醇的硝酸酯的方法

    公开(公告)号：US3875206A

    公开(公告)日：1975-04-01

    申请号：US44798474

    申请日：1974-03-04

    Applicant: HOECHST AG

    Inventor： SCHUIERER ERICH ,  ULM KLAUS ,  REBSDAT SIEGFRIED ,  WIMMER IGNAZ

    IPC: C07C31/40 ,  C07C203/00 ,  C07C203/04 ,  C07C77/02

    CPC classification number: C07C29/132 ,  C07C201/02 ,  C07C201/04 ,  C07C203/04 ,  C07C203/00 ,  C07C31/40

    Abstract: 2-Perfluoroalkyl ethanols are obtained by reacting 2-perfluoroalkyl ethyliodides with at least the two-fold molar amount of nitric acid of about 70 to 98 percent strength and hydrogenating the intermediates, which are the nitrates of the desired ethanols. The products are useful as starting materials for the production of hydrophobic and oleophobic textile finishing agents, e.g. the polymer acrylates and methacrylates of said 2perfluoroalkyl-ethanols.

    Abstract translation: 2-全氟烷基乙醇通过使2-全氟烷基乙基碘化物与至少两倍摩尔量的硝酸浓度为约70-98％的强度反应并氢化作为所需乙醇的硝酸盐的中间体来获得。 该产品可用作生产疏水和疏油纺织整理剂的起始材料，例如， 所述2-全氟烷基 - 乙醇的聚合物丙烯酸酯和甲基丙烯酸酯。

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