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公开(公告)号：US10676532B2
公开(公告)日：2020-06-09
申请号：US15915658
申请日：2018-03-08
发明人： Kamon Shirakawa
IPC分类号： A61K39/00 , C07K16/28 , G01N33/68 , G01N33/569
摘要： The present invention provides methods and compositions for determining sepsis in an individual. Specifically, the present invention provides for antibodies of fragments thereof that specifically bind to presepsin. The antibodies of the present invention may be monoclonal antibodies, and they may specifically bind to a particular epitope of presepsin. The present invention further provides methods of using such antibodies to determine whether an individual has sepsis, and kits comprising the disclosed antibodies.
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152.发明授权公开(公告)号：US10668038B2
公开(公告)日：2020-06-02
申请号：US15631104
申请日：2017-06-23
IPC分类号： A61K31/202 , A61K9/08 , A61K9/107 , A61K9/12 , A61K31/20 , A61K31/225 , A61K47/14 , A61K47/34 , A61K47/44 , A23D7/01 , A23D7/015 , A23L33/12 , A61K45/06 , A61K9/14
摘要： Novel compositions comprising omega-3 fatty acids and uses thereof are disclosed.
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公开(公告)号：US20190337897A1
公开(公告)日：2019-11-07
申请号：US16514835
申请日：2019-07-17
发明人： Fumihiko SAITOH , Hiroshi NAGASUE
IPC分类号： C07D213/75 , C07D417/04 , C07C271/24 , C07D213/81 , C07D405/14 , C07D405/04 , C07D213/84 , C07D401/04 , C07D413/12 , C07C215/44 , A61K45/06 , A61K31/4433 , A61K31/444 , A61K31/4439 , A61K31/506 , A61K31/4418 , A61P3/10 , A61P25/08 , A61P9/12 , A61P7/00 , A61P43/00 , A61P19/02 , A61P1/04 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P11/04 , A61P31/18 , A61P13/08 , A61P37/00 , A61P1/18 , A61P19/10 , A61P35/02 , A61P5/14 , A61P35/00 , A61P29/00 , A61P25/28 , A61P9/00 , A61P9/06 , A61P21/00 , A61P25/20 , A61P25/16 , A61P25/04 , A61P13/10 , A61P29/02 , A61P15/00 , A61P25/24 , A61P37/06 , A61P11/00 , A61P13/02 , A61P25/00 , A61P21/02 , A61P1/00 , A61P3/04 , A61P3/06 , A61P31/00 , A61P1/02 , A61P1/16
摘要： The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like). Specifically, the present invention provides a compound or an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or the like, the compound
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公开(公告)号：US20190231731A1
公开(公告)日：2019-08-01
申请号：US16380663
申请日：2019-04-10
发明人： Shigeru KIMURA , Hiromitsu ITO , Hirosato FUJII , Motoo YAMAGATA
IPC分类号： A61K31/202 , A61K9/107 , A61K47/14 , A61K31/232 , A61K47/10 , A23L29/10 , A61K9/48 , A61K47/26 , A23L33/115
CPC分类号： A61K31/202 , A23L29/10 , A23L33/115 , A61K9/1075 , A61K9/4858 , A61K31/232 , A61K47/10 , A61K47/14 , A61K47/26
摘要： A self-emulsifying composition contains: 70 to 90% by weight in total of one or more compounds selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 1 to 29% by weight of an emulsifying agent selected from among a polyoxyethylene sorbitan fatty acid ester, a sorbitan fatty acid ester, a glycerin fatty acid ester and a polyoxyl castor oil; and 0.5 to 6% by weight of water when the composition is defined to be 100% by weight as a whole. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.
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公开(公告)号：US20190209260A1
公开(公告)日：2019-07-11
申请号：US16316097
申请日：2017-07-13
发明人： Taichi ITO , Seiichi OHTA , Norihiro KOKUDO , Mitsuko ISAJI , Satoshi SHIMIZU
CPC分类号： A61B90/08 , A61B2090/0816 , A61L31/04 , A61L31/12 , A61L31/128 , A61L31/14 , A61L31/146 , A61L2420/08
摘要： [Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded.[Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
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156.发明授权公开(公告)号：US10105340B2
公开(公告)日：2018-10-23
申请号：US15878827
申请日：2018-01-24
发明人： Nobushige Doisaki , Shingo Arato , Takuro Fukae
IPC分类号： A61K31/20 , A61K31/232 , C07C67/54 , C07C67/03 , C11B3/12 , C07C67/56 , C11C3/10 , C07C69/587
摘要： Provided are: a composition containing 96-99 area % of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7 area % or less, and an eicosapentaenoic-acid-alkyl-ester mono-trans isomer content of 2.5 area % or less; and a method for producing a composition containing a high concentration of eicosapentaenoic acid alkyl ester, the method including performing precision distillation on a composition containing eicosapentaenoic acid alkyl ester, obtained by alkyl esterification of a raw material oil containing eicosapentaenoic acid, under a vacuum of 0.2 Ton or lower and a temperature of 190° C. or lower in the entire column, and performing a concentration treatment on the precision-distilled composition using chromatography.
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公开(公告)号：US10092536B2
公开(公告)日：2018-10-09
申请号：US15409315
申请日：2017-01-18
发明人： Hirosato Fujii , Motoo Yamagata
IPC分类号： A61K31/00 , A61K31/202 , A61K31/232 , A61K47/46 , A61K47/44 , A61K47/10 , A61K47/26 , A61K9/107
摘要： This invention provides a self-emulsifying composition comprising 50 to 95% by weight in total of at least one compound selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; and 5 to 50% by weight of an emulsifier having a hydrophilic lipophilic balance of at least 10. The composition has no or reduced ethanol content, and exhibits excellent self-emulsifying property, dispersibility in the composition, emulsion stability, and absorption property. The composition is adapted for use as a drug.
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公开(公告)号：US20180237537A1
公开(公告)日：2018-08-23
申请号：US15754451
申请日：2015-08-25
发明人： Kamon SHIRAKAWA
IPC分类号： C07K16/28 , C07K16/06 , G01N33/557 , G01N33/53
CPC分类号： C07K16/2896 , C07K7/06 , C07K16/065 , C07K2317/31 , C07K2317/92 , G01N33/5306 , G01N33/557
摘要： The present invention provides anti-presepsin polyclonal antibodies specifically binding to a peptide comprising an amino acid sequence of SEQ ID NO: 1. As a result, anti-presepsin polyclonal antibodies which have less variation in measured values between lot-to-lot differences of antibodies compared to S68 antibodies and thus suitable anti-presepsin polyclonal antibodies for presepsin measurement are provided.
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公开(公告)号：US20170368184A1
公开(公告)日：2017-12-28
申请号：US15545197
申请日：2015-01-21
发明人： Hiromitsu ITO , Hirosato FUJII , Motoo YAMAGATA
IPC分类号： A61K47/44 , A61K47/24 , A61K31/232 , A61K47/26 , A61K9/107
摘要： A self-emulsifying composition contains: 70 to 90% by weight of at least one compound selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 0.5 to 6% by weight of water; 1 to 29% by weight of a polyoxyethylene sorbitan fatty acid ester as an emulsifier (optionally including a polyoxyl castor oil, and not including lecithin); and lecithin in an amount of 3 to 40 parts by weight in relation to 100 parts by weight of ω3 polyunsaturated fatty acids and the like. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.
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公开(公告)号：US09808445B2
公开(公告)日：2017-11-07
申请号：US15303322
申请日：2015-04-10
发明人： Isao Sakurada , Tomokazu Hirabayashi , Yoshitaka Maeda , Hiroshi Nagasue , Takashi Mizuno , Jiayi Xu , Ting Zhang , Cameron Smith , Dann Parker
IPC分类号： A61K31/501 , A61K31/439 , C07D413/14 , C07D261/20 , C07D413/04 , C07D498/04 , C07D209/52 , C07D519/00 , A61K31/444 , A61K31/506 , A61K45/06
CPC分类号： A61K31/439 , A61K31/444 , A61K31/501 , A61K31/506 , A61K45/06 , C07D209/52 , C07D261/20 , C07D413/04 , C07D413/14 , C07D498/04 , C07D519/00
摘要： In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
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