公开(公告)号：US20150259669A1

公开(公告)日：2015-09-17

申请号：US14427374

申请日：2013-09-17

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Harold D. May ,  Christopher W. Marshall ,  Edward V. Labelle

IPC: C12N13/00 ,  C12P7/54 ,  C12P7/62 ,  C12P3/00

CPC classification number: C12N13/00 ,  C12N1/20 ,  C12N1/36 ,  C12P3/00 ,  C12P5/023 ,  C12P7/52 ,  C12P7/54 ,  C12P7/625 ,  C12P39/00 ,  Y02E50/343

Abstract: Methods are provided for microbial electrosynthesis of H2 and organic compounds such as methane and acetate. Method of producing mature electrosynthetic microbial populations by continuous culture is also provided. Microbial populations produced in accordance with the embodiments as shown to efficiently synthesize H2, methane and acetate in the presence of CO2 and a voltage potential. The production of biodegradable and renewable plastics from electricity and carbon dioxide is also disclosed.

Abstract translation: 提供了用于微生物电合成H2和有机化合物如甲烷和乙酸盐的方法。 还提供了通过连续培养生产成熟的电合成微生物种群的方法。 根据所示的实施方案生产的微生物群体在CO 2和电压潜力的存在下有效地合成H 2，甲烷和乙酸盐。 还公开了从电和二氧化碳生产可生物降解和可再生塑料。

公开(公告)号：US20150228073A1

公开(公告)日：2015-08-13

申请号：US14618345

申请日：2015-02-10

Applicant: MUSC Foundation for Research Development

Inventor： Jens Jensen ,  Sai Kam Hui ,  Joseph Helpern

IPC: G06T7/00

CPC classification number: G06T7/0012 ,  G01R33/56341 ,  G06T2207/10088 ,  G06T2207/20076 ,  G06T2207/30016

Abstract: One aspect of the present disclosure relates to a system that can perform double pulsed diffusional kurtosis imaging (DP-DKI). Image data can be received. The image data can be acquired using a double pulsed field gradient (d-PFG) diffusion sequence. A six dimensional (6D) diffusional kurtosis for the image data can be determined. A magnitude of the image data can be determined in terms of the 6D diffusional kurtosis. DP-DKI can isolate the contributions to the d-PFG diffusion sequence, which can represent leading diffusion effects, that cannot be seen from single pulsed field gradient (s-PFG) diffusion sequences.

Abstract translation: 本公开的一个方面涉及可执行双脉冲扩散峭度成像（DP-DKI）的系统。 可以接收图像数据。 可以使用双脉冲场梯度（d-PFG）扩散序列来获取图像数据。 可以确定图像数据的六维（6D）扩散峰度。 可以根据6D扩散峰度来确定图像数据的大小。 DP-DKI可以分离对d-PFG扩散序列的贡献，这可以代表主要的扩散效应，从单脉冲场梯度（s-PFG）扩散序列看不到。

公开(公告)号：US09079853B2

公开(公告)日：2015-07-14

申请号：US13798383

申请日：2013-03-13

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Craig C. Beeson ,  Christopher C. Lindsey ,  Yuri K. Peterson ,  Baerbel Rohrer

IPC: C07D209/36 ,  C07D209/38 ,  C07D401/06 ,  C07D403/06 ,  C07D401/04 ,  C07D403/04 ,  C07D209/34

CPC classification number: C07D401/06 ,  C07D209/34 ,  C07D209/36 ,  C07D209/38 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。

公开(公告)号：US20150065434A1

公开(公告)日：2015-03-05

申请号：US14473305

申请日：2014-08-29

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Patrick M. WOSTER ,  Isuru R. KUMARASINGHE

IPC: C07K14/00

CPC classification number: A61K38/1709

Abstract: Provided herein are cyclic peptide inhibitors of lysine-specific demethylase 1. These cyclic peptides have the potential to treat cancer, diabetes, cardiovascular disease, and neurological disorders.

Abstract translation: 本文提供赖氨酸特异性脱甲基酶1的环肽抑制剂。这些环肽具有治疗癌症，糖尿病，心血管疾病和神经障碍的潜力。

公开(公告)号：US20150057247A1

公开(公告)日：2015-02-26

申请号：US14526721

申请日：2014-10-29

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Craig C. Beeson ,  Christopher C. Lindsey ,  Yuri K. Peterson ,  Baerbel Rohrer

IPC: C07F7/10 ,  C07D401/14 ,  C07D403/06 ,  C07D401/04

CPC classification number: C07F7/0814 ,  C07D231/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07F7/10

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。

公开(公告)号：US08921401B2

公开(公告)日：2014-12-30

申请号：US13798394

申请日：2013-03-13

Applicant: MUSC Foundation for Research Development

Inventor： Craig C. Beeson ,  Christopher C. Lindsey ,  Yuri K. Peterson ,  Baerbel Rohrer

IPC: C07D401/04 ,  A61K31/4439 ,  C07D403/06 ,  C07D403/04 ,  C07D401/14 ,  C07D231/14 ,  C07D401/06 ,  C07F7/08

CPC classification number: C07F7/0814 ,  C07D231/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07F7/10

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。

公开(公告)号：US20140349944A1

公开(公告)日：2014-11-27

申请号：US14285992

申请日：2014-05-23

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Zihai LI ,  Feng HONG

IPC: C07K14/705 ,  A61K47/48 ,  A61K38/17

CPC classification number: C07K14/70546 ,  A61K38/00

Abstract: The present disclosure provides isolated integrin αL polypeptides, such as α7 helix polypeptides from the alpha I domain of integrin. Such polypeptides inhibit the interaction between integrin and gp96, thereby inhibiting gp96 activity. Such inhibition can be used to prevent cancer cell growth, cancer metastasis and/or inflammation.

Abstract translation: 本公开提供分离的整联蛋白αL多肽，例如来自整联蛋白的α1结构域的α7螺旋多肽。 这样的多肽抑制整联蛋白和gp96之间的相互作用，从而抑制gp96活性。 这种抑制可用于预防癌细胞生长，癌转移和/或炎症。

公开(公告)号：US20140275075A1

公开(公告)日：2014-09-18

申请号：US13798383

申请日：2013-03-13

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Craig C. BEESON ,  Christopher C. LINDSEY ,  Yuri K. PETERSON ,  Baerbel ROHRER

IPC: C07D209/36 ,  C07D403/06 ,  C07D401/06

CPC classification number: C07D401/06 ,  C07D209/34 ,  C07D209/36 ,  C07D209/38 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。

公开(公告)号：US20140154307A1

公开(公告)日：2014-06-05

申请号：US14183213

申请日：2014-02-18

Applicant: MUSC Foundation for Research Development ,  National Jewish Health ,  The Regents of the University of Colorado, a body corporate

Inventor： V. Michael HOLERS ,  Joshua M. Thurman ,  Christian Taube ,  Erwin W. Gelfand ,  Gary Steven Gilkeson

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/544 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30

Abstract: Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway.

Abstract translation: 公开了替代补体途径的新型抑制剂，特别是新型抗因子B抗体。 还公开了这样的抑制剂通过选择性地抑制替代性补体途径来减少或预防气道高反应性和/或气道炎症的用途，从而治疗这些病症起作用的疾病。 还公开了通过抑制替代补体途径来使用这种抑制剂来减少或预防其它疾病和病症，包括缺血再灌注损伤。

公开(公告)号：US20140073572A1

公开(公告)日：2014-03-13

申请号：US14043317

申请日：2013-10-01

Applicant: MUSC Foundation for Research Development ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Gary GILKESON ,  Stephen Tomlinson ,  V. Michael Holers ,  Baerbel Rohrer

IPC: C07K14/705 ,  C07K14/47

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K14/70596 ,  C07K2319/00

Abstract: The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.

Abstract translation: 本发明提供包含CR2部分的CR2-FH分子，其包含CR2蛋白或其片段和包含因子H蛋白或其片段的FH部分和包含CR2-FH分子的药物组合物。 还提供了使用组合物治疗涉及替代补体途径的疾病的方法，例如年龄相关性黄斑变性，类风湿性关节炎和缺血再灌注。