公开(公告)号：US08998034B2

公开(公告)日：2015-04-07

申请号：US12901420

申请日：2010-10-08

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D37/00 ,  F16K15/14 ,  B65B55/08 ,  B29B11/08 ,  B65D83/00 ,  B29B11/14 ,  B29C49/06 ,  B29K23/00 ,  B29K67/00 ,  B29K105/00

CPC classification number: B65D47/2081 ,  B05B11/047 ,  B29B11/08 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14053 ,  B29B2911/14066 ,  B29B2911/1408 ,  B29B2911/14093 ,  B29B2911/14106 ,  B29B2911/14113 ,  B29B2911/14133 ,  B29B2911/1414 ,  B29B2911/14326 ,  B29B2911/14333 ,  B29B2911/1442 ,  B29B2911/14473 ,  B29B2911/1452 ,  B29C49/06 ,  B29C73/025 ,  B29K2023/12 ,  B29K2067/00 ,  B29K2105/258 ,  B65B51/023 ,  B65B55/08 ,  B65D51/002 ,  B65D83/0061 ,  F16K15/147 ,  Y10T137/7837

Abstract: A device includes a first part having a co-molded first support, valve cover and elastic actuator, and a second part having an injection molded second support, valve seat, and variable-volume storage chamber pre-form. The pre-form is blow molded into a flexible pouch defining the variable-volume storage chamber. The one-way valve includes a semi-annular, curvilinear, relatively rigid valve seat defining axially-extending, opposing first marginal portions, and an axially-extending first mid-portion angularly extending between the opposing first marginal portions. A flexible valve member is superimposed on the valve seat and defines axially-extending, opposing second marginal portions fixedly secured on or adjacent to respective first marginal portions of the valve seat, and an axially-extending second mid-portion angularly extending between the opposing first marginal portions and superimposed onto the first mid-portion of the valve seat. The flexible valve cover and valve seat form a normally closed axially and angularly extending valve seam therebetween.

Abstract translation: 装置包括具有共模塑的第一支撑件，阀盖和弹性致动器的第一部件，以及具有注射成型的第二支撑件，阀座和可变容积的储存室预成型件的第二部件。 预成型件被吹塑成定义可变容积储存室的柔性袋。 单向阀包括限定轴向延伸的相对的第一边缘部分的半环形曲线的相对刚性的阀座，以及在相对的第一边缘部分之间成角度地延伸的轴向延伸的第一中间部分。 柔性阀构件叠加在阀座上并且限定轴向延伸的相对的第二边缘部分，其固定地固定在阀座的相应的第一边缘部分上或邻近阀座的相应的第一边缘部分，以及轴向延伸的第二中间部分，其在相对的第一 边缘部分并重叠在阀座的第一中间部分上。 柔性阀盖和阀座在其间形成常闭轴向和角度延伸的阀接缝。

公开(公告)号：US08966866B2

公开(公告)日：2015-03-03

申请号：US13861502

申请日：2013-04-12

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/04 ,  B67B1/03 ,  B65B51/02 ,  B65B55/08 ,  B65B3/00 ,  B65B61/00 ,  B65B7/16

CPC classification number: B65B3/003 ,  B65B7/16 ,  B65B51/02 ,  B65B55/04 ,  B65B55/08 ,  B65B55/10 ,  B65B61/002 ,  B65B2039/009

Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.

Abstract translation: 用于无菌填充的装置和方法包括使包括针穿透隔膜的装置的针穿透表面和与针可穿透隔膜流体连通的密封室中的污染。 填充针穿透针穿透隔膜，通过填充针引入物质并进入腔室，然后从隔膜中取出。 将液体密封剂施加到隔膜的穿透区域。 将辐射或能量施加到液体密封剂以将液体密封剂从液相固化至固相。

公开(公告)号：US08739838B2

公开(公告)日：2014-06-03

申请号：US13352235

申请日：2012-01-17

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy

IPC: B65B1/04 ,  G01N23/00 ,  B65B51/10 ,  A61M5/178 ,  B29C65/00 ,  A61L2/10

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one filling or needle assembly and is adjustable to receive a plurality of filling or needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of containers or vials that are to be filled concurrently and adjusting an assembly to include at least one filling or needle assembly and at least one seal assembly. A number of the filling or needle assemblies and the seal assemblies equals the number of containers or vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个填充物或针头组件，并且可调节以容纳多个填充物或针头组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的多个容器或小瓶，并且调整组件以包括至少一个填充物或针组件和至少一个密封组件。 许多填充物或针组件和密封组件等于容器或小瓶的数量。

公开(公告)号：US08672195B2

公开(公告)日：2014-03-18

申请号：US11938103

申请日：2007-11-09

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D5/72

CPC classification number: B65D47/205 ,  A45D40/26 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D83/0055

Abstract: A container including a nozzle and body depending therefrom. The body is preferably tubular and defines an interior which retains a product to be dispensed. A cap engages the nozzle to prevent inadvertent release of the product. In order to dispense the product, the cap is removed and pressure is applied to the body and the nozzle allows release of the product. The nozzle releases the product without exposing the remaining product to the external atmosphere, thus the sterility of the interior of the body is maintained and the shelf life of the product is increased. The nozzle includes an inner body, coupled to the tubular body, surrounded by a flexible outer cover. A seam between the inner body and flexible outer cover forms a one-way release valve wherein a portion of the seam remains closed during dispensing the product.

Abstract translation: 一种容器，其包括从其排出的喷嘴和主体。 主体优选地是管状的并且限定保持要分配的产品的内部。 盖子与喷嘴接合以防止产品的意外释放。 为了分配产品，盖被去除并且压力施加到主体上，并且喷嘴允许释放产品。 喷嘴释放产品而不将剩余的产品暴露于外部大气，从而维持身体内部的不整洁性并且提高了产品的保质期。 该喷嘴包括一个连接到管状主体的内部主体，被一个柔性的外盖包围。 内体和柔性外盖之间的接缝形成单向释放阀，其中在分配产品期间，接缝的一部分保持关闭。

公开(公告)号：US08646243B2

公开(公告)日：2014-02-11

申请号：US12245678

申请日：2008-10-03

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/00

CPC classification number: A23L3/04 ,  A23L2/46 ,  A23L3/22 ,  B65B3/04 ,  B65B55/025 ,  B65B55/10 ,  B65B55/12

Abstract: An apparatus and method are provided for formulating and aseptically filling liquid products. A first liquid source includes at least one first liquid component; a second liquid source includes at least one second liquid component; and a container includes a body defining an empty, sterile storage chamber therein that is sealed with respect to ambient atmosphere. The container is introduced into a sterile filling chamber. A first filling member coupled in fluid communication with the first liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the first liquid component is aseptically introduced through the first filling member and into the storage chamber. A second filling member coupled in fluid communication with the second liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the second liquid component is aseptically introduced through the second filling member and into the storage chamber and, in turn, the first and second liquid components are combined into a liquid product formulation within the sterile chamber of the container. The first and second filling members are withdrawn from fluid communication with the storage chamber of the container located within the sterile filling chamber, and the filled storage chamber is sealed with respect to ambient atmosphere to hermetically seal the liquid product formulation within the storage chamber of the container.

Abstract translation: 提供了用于配制和无菌灌装液体产品的装置和方法。 第一液体源包括至少一个第一液体组分; 第二液体源包括至少一个第二液体组分; 并且容器包括在其中限定相对于环境大气密封的空的无菌储存室的主体。 将容器引入无菌填充室。 与第一液体源流体连通的第一填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，第一液体组分被无菌地通过第一填充构件引入储存室 。 与第二液体源流体连通的第二填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，并且第二液体组分被无菌地通过第二填充构件引入并进入储存室 而又将第一和第二液体组分组合成容器无菌室内的液体产品制剂。 第一和第二填充构件与位于无菌填充室内的容器的储存室流体连通地取出，并且填充的储存室相对于环境大气密封，以将液体产品配制物气密地密封在储存室内 容器。

公开(公告)号：US20130283733A1

公开(公告)日：2013-10-31

申请号：US13861502

申请日：2013-04-12

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/04

CPC classification number: B65B3/003 ,  B65B7/16 ,  B65B51/02 ,  B65B55/04 ,  B65B55/08 ,  B65B55/10 ,  B65B61/002 ,  B65B2039/009

Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.

Abstract translation: 用于无菌填充的装置和方法包括使包括针穿透隔膜的装置的针穿透表面和与针可穿透隔膜流体连通的密封室中的污染。 填充针穿透针穿透隔膜，通过填充针引入物质并进入腔室，然后从隔膜中取出。 将液体密封剂施加到隔膜的穿透区域。 将辐射或能量施加到液体密封剂以将液体密封剂从液相固化至固相。

公开(公告)号：US20130020321A1

公开(公告)日：2013-01-24

申请号：US13396053

申请日：2012-02-14

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D55/00 ,  B65B7/00

CPC classification number: B29C67/004 ,  B29C45/006 ,  B29C45/1701 ,  B29C45/42 ,  B29C65/16 ,  B29C65/1616 ,  B29C66/001 ,  B29C66/0018 ,  B29C66/71 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/961 ,  B29C2791/005 ,  B29L2031/565 ,  B65B3/003 ,  B65B3/022 ,  B65B55/06 ,  B29C65/00 ,  B29K2023/38

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：US20130008137A1

公开(公告)日：2013-01-10

申请号：US13529951

申请日：2012-06-21

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/02

CPC classification number: B65B55/10 ,  B65B25/001 ,  B65B25/008

Abstract: A method for sterilizing a container is provided where a penetrable septum of a sealed empty device is penetrated with an injection member. A fluid sterilant is then injected through the injection member and into an interior chamber of the device. The fluid sterilant is allowed to reside within the chamber a sufficient amount of time to render the chamber either sterile or bactericidal. Product can then be introduced through the septum into the sterile or bactericidal chamber. The resulting penetration aperture is then resealed to hermetically seal the product within the chamber.

Abstract translation: 提供了一种用于对容器进行灭菌的方法，其中密封的空装置的可穿透的隔膜用注射构件穿透。 然后将流体灭菌剂通过注射构件注入装置的内部室中。 允许流体灭菌剂在室内停留足够的时间以使得室无菌或杀菌。 然后将产品通过隔膜引入无菌或杀菌室。 然后将所得到的穿透孔重新密封以将产品气密密封在腔室内。

公开(公告)号：USD667559S1

公开(公告)日：2012-09-18

申请号：US29400406

申请日：2011-08-26

Applicant: Daniel Py

Designer： Daniel Py

公开(公告)号：US20120152881A1

公开(公告)日：2012-06-21

申请号：US13329483

申请日：2011-12-19

Applicant: Daniel Py ,  Debashis Sahoo ,  Norbert M. Assion ,  Julian V. Chan

Inventor： Daniel Py ,  Debashis Sahoo ,  Norbert M. Assion ,  Julian V. Chan

IPC: A61J9/00

CPC classification number: A61J9/00 ,  A61J1/2093

Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

Abstract translation: 一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及包含用于在储存期间气密地密封室内的产品的主密封件的容器盖。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。 容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到 允许产品从腔室通过流出口并进入分配构件以分配产品。