公开(公告)号：US20220289803A1

公开(公告)日：2022-09-15

申请号：US17664589

申请日：2022-05-23

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  Iraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28

Abstract: The invention provides an effectoriess immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20220262458A1

公开(公告)日：2022-08-18

申请号：US17629327

申请日：2020-07-24

Applicant: Genentech, Inc.

Inventor： Yasin SENBABAOGLU ,  Christine Carine MOUSSION

IPC: G16B20/00 ,  G16B40/30

Abstract: Embodiments disclosed herein generally relate to classifying a tumor, based on gene expression data, as being neurally related or non-neurally related. The tumor may be classified using a machine-learning model, which may have been trained to differentiate gene-expression data associated with neuronal or neuroendocrine tumors from gene-expression data associated with non-neuronal and non-neuroendocrine tumors. Differential treatment and/or treatment recommendations may be provided based on the classification. First-line checkpoint blockade therapy may be used or recommended when a tumor is identified as being non-neurally related, and a combination therapy (e.g., initial chemotherapy and subsequent checkpoint blockade therapy) may be used or recommended when a tumor is identified as being neurally related.

公开(公告)号：US20220230310A1

公开(公告)日：2022-07-21

申请号：US17665932

申请日：2022-02-07

Applicant: Genentech, Inc.

Inventor： Luke XIE ,  Kai Henrik BARCK ,  Omid BAZGIR

IPC: G06T7/00 ,  G06V10/764 ,  G06T7/70 ,  G06T7/10 ,  G06T7/62 ,  G06V10/75 ,  G06V20/64

Abstract: The present disclosure relates to techniques for segmenting objects within medical images using a deep learning network that is localized with object detection based on a derived contrast mechanism. Particularly, aspects are directed to localizing an object of interest within a first medical image having a first characteristic, projecting a bounding box or segmentation mask of the object of interest onto a second medical image having a second characteristic to define a portion of the second medical image, and inputting the portion of the second medical image into a deep learning model that is constructed as a detector using a weighted loss function capable of segmenting the portion of the second medical image and generating a segmentation boundary around the object of interest. The segmentation boundary may be used to calculate a volume of the object of interest for determining a diagnosis and/or a prognosis of a subject.

公开(公告)号：US20220226326A1

公开(公告)日：2022-07-21

申请号：US17409644

申请日：2021-08-23

Applicant: Array BioPharma Inc. ,  Genentech, Inc.

Inventor： Ian S. Mitchell ,  James F. Blake ,  Rui Xu ,  Nicholas C. Kallan ,  Dengming Xiao ,  Keith Lee Spencer ,  Josef R. Bencsik ,  Eli M. Wallace ,  Stephen T. Schlachter ,  Anna L. Leivers ,  Jun Liang ,  Brian Safina ,  Birong Zhang ,  Christine Chabot ,  Steven Do

IPC: A61K31/517 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D239/70 ,  C07D413/12 ,  C07D407/12

Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US20220211797A1

公开(公告)日：2022-07-07

申请号：US17392724

申请日：2021-08-03

Applicant: GENENTECH, INC.

Inventor： Frederick COHEN ,  Lewis J. GAZZARD ,  Vickie Hsiao-Wei TSUI ,  John A. FLYGARE

IPC: A61K38/06 ,  C07K5/09 ,  C07K5/083 ,  C07K5/08 ,  C07K5/087 ,  A61K45/06

Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.

公开(公告)号：US20220204517A1

公开(公告)日：2022-06-30

申请号：US17654131

申请日：2022-03-09

Applicant: Genentech, Inc.

Inventor： Yun-Xing Cheng ,  Paul Gibbons ,  Terry Kellar ,  Wei Li ,  Rohan Mendonca ,  Po-wai Yuen ,  Mark Edward Zak ,  Lei Zhang

IPC: C07D487/04 ,  C07D519/00

Abstract: Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20220203041A1

公开(公告)日：2022-06-30

申请号：US17675509

申请日：2022-02-18

Applicant: Hoffmann-La Roche Inc. ,  GENENTECH, INC.

Inventor： Frank BAMBERG ,  Heather L. FLORES ,  Robert MÜLLER ,  Elisabeth SCHAIBLE ,  Edward SCHWARB ,  Lionel VEDRINE ,  Kewei YANG ,  Mathieu RIGOLLET ,  Pierre GOLDBACH ,  Baboo Dushyantsingh GOORDYAL ,  Ivy LIN ,  Florian WILDENHAHN

IPC: A61M5/32 ,  A61M5/00 ,  A61L31/10 ,  A61L31/16 ,  A61M5/315 ,  B65B3/00 ,  B65B7/16

Abstract: A syringe (18) has a longitudinal body (28) with an interior (228) in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body (228) and a rigid needle shield (38) encasing the needle. The rigid needle shield (38) is essentially water vapour tight. The syringe (18) according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.

公开(公告)号：US11370838B2

公开(公告)日：2022-06-28

申请号：US15414330

申请日：2017-01-24

Applicant: GENENTECH, INC.

Inventor： Jayme Franklin ,  Xin Xin Lin ,  Jeffrey Gorrell ,  Timothy Tully ,  Matthew Hutchinson ,  Charity Tucker Bechtel

IPC: A61K38/07 ,  C07K16/28 ,  C07K1/113 ,  A61K47/65 ,  A61K47/68

Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.

公开(公告)号：US20220186314A1

公开(公告)日：2022-06-16

申请号：US17580357

申请日：2022-01-20

Applicant: GENENTECH, INC.

Inventor： Jason A. Hackney ,  Mary Keir ,  Gaik Wei Tew

IPC: C12Q1/6883 ,  G01N33/573 ,  G01N33/53

Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.

公开(公告)号：US11333644B2

公开(公告)日：2022-05-17

申请号：US16275849

申请日：2019-02-14

Applicant: Genentech, Inc.

Inventor： Mary Montti ,  Richard L. Beardsley ,  Michael S. Chinn

IPC: A61K47/10 ,  A61K47/26 ,  B01D15/38 ,  G01N30/36 ,  G01N30/96

Abstract: The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.