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161.发明授权公开(公告)号：US10849490B2
公开(公告)日：2020-12-01
申请号：US15754985
申请日：2016-08-25
Inventor： Larry N. Thibos , Tao Liu
IPC: A61B3/00 , G16H30/40 , A61B3/10 , A61B3/103 , A61B3/107 , A61B3/11 , A61B3/12 , A61B3/14 , A61F2/16 , A61F9/008 , G02C7/02 , A61B18/20
Abstract: Methods are disclosed comprising measuring, with a first scanner, a central part of the visual image, measuring, with a second scanner, a peripheral part of the visual image, calculating, by a processor, a pan-retinal measure of image contrast for an extended area of the retina, and optimizing a pan-retinal visual quality. Methods further comprising optimizing a pan-retinal visual quality are also disclosed. Systems are also disclosed comprising either a scanner or a laser, a non-transitory memory having instructions that, in response to an execution by a processor, the processor receives a first measurement of the central part of the visual image, receives a second measurement of the peripheral part of the visual image, and calculates a pan-retinal measure of image contrast for an extended area of the retina. Methods of manufacturing lenses, including contact lenses are disclosed.
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162.发明申请公开(公告)号：US20200345692A1
公开(公告)日：2020-11-05
申请号：US16963075
申请日：2019-01-18
Inventor： Roberto Pili
IPC: A61K31/404 , A61K31/4166 , G01N33/574 , A61P35/00
Abstract: Disclosed herein are compositions and methods for treating cancer. More particularly, the present disclosure relates to compositions and methods for treating cancer including prostate cancer, renal cell carcinoma, hepatocellular carcinoma, thyroid cancer, sarcoma breast cancer, and gastrointestinal stromal tumor. The present disclosure also relates to methods for identifying subjects having drug resistant prostate cancer and drug resistant renal cell carcinoma.
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公开(公告)号：US10809324B2
公开(公告)日：2020-10-20
申请号：US16322911
申请日：2017-08-03
Inventor： Richard Moore , Jesse Goode
IPC: F16M11/00 , G01R33/28 , G01R33/48 , G06F1/16 , F16M11/04 , F16M11/42 , F16M13/00 , F16M13/02 , H04M1/04
Abstract: A support (26) for a tablet (22) for use in a Functional Magnetic Resonance Imaging (fMRI) machine (12) is provided. The support (26) includes a plurality of curved braces (80, 82) configured to mount within a bore (16) of the fMRI machine (12); a channel (90) coupled to one end of the curved braces (80, 82); and a pair of lower braces (86) coupled to another end of the curved braces (80, 82); wherein the channel (90) includes a C-shaped opening (108) configured to receive a mounting bracket (24) coupled to the tablet (22).
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公开(公告)号：US10730923B2
公开(公告)日：2020-08-04
申请号：US16241932
申请日：2019-01-07
Inventor： Richard D. DiMarchi , David L. Smiley
IPC: A61K38/26 , C07K14/605 , A61K47/60 , G01N33/74 , A61K39/395 , C07K16/28 , A61K49/00 , A61K38/00
Abstract: Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.
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公开(公告)号：US20200230255A1
公开(公告)日：2020-07-23
申请号：US16749832
申请日：2020-01-22
Inventor： Yan Yu
Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.
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Patent Agency Ranking
公开(公告)号：US20200095557A1
公开(公告)日：2020-03-26
申请号：US16580954
申请日：2019-09-24
Inventor： Nicanor I. Moldovan , Mervin C. Yoder , Nutan Prasain
Abstract: Co-culture of isolated human induced pluripotent stem cell (iPSC)-derived endothelial and smooth-muscle progenitor cells results in the formation of cellular spheroids having capillary-like structures (referred to herein as ‘capillary fragments’) at their core. Bioprinting of these spheroids into scaffold-free tissue constructs facilitates the development of microvasculature within the engineered tissue. Methods of using these bioprinted engineered tissues for cell therapy are also disclosed.
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公开(公告)号：US10592687B2
公开(公告)日：2020-03-17
申请号：US15029559
申请日：2014-10-09
Inventor： Apu Kapadia , Robert E. Templeman , David Crandall , Mohammed Korayem
IPC: G06F21/00 , G06F21/62 , G06F16/51 , G06F16/583 , G06F16/58 , G06K9/62 , G06K9/00 , G06K9/46 , G06K9/78
Abstract: A method and device for classifying collected images. The method and device include instructions to compare a captured image to a known set of images to determine the location depicted therein; and applying a classification upon the image based upon the determined location depicted therein and whether the determined location indicates that the image has the potential to depict privacy sensitive information.
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公开(公告)号：US10563175B2
公开(公告)日：2020-02-18
申请号：US15124280
申请日：2015-03-11
Inventor： Mervin Yoder , Nutan Prasain
Abstract: The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ECFC-like cells) is provided. A purified human cell population of NRP-1+CD31+ ECFC-like cells is provided, wherein at least some of the cells in the population have a high proliferation potential. Therapeutic and test agent screening methods for using the cell populations of the present disclosure are provided.
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公开(公告)号：US10556016B2
公开(公告)日：2020-02-11
申请号：US15513143
申请日：2015-09-23
Inventor： Yan Yu
Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.
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公开(公告)号：US20200043143A1
公开(公告)日：2020-02-06
申请号：US16603807
申请日：2018-04-09
Inventor： Paul Richard Territo , Paul Salama , Juan Antonio Chong
Abstract: A computing device is provided having at least one processor (104) operative to facilitate motion correction in a medical image file (102). The at least one processor (104) is configured to generate at least one unified frame file (110) based on motion image data (204), depth map data (206) corresponding to the motion image data, and region of interest data (200). Further, at least one corrected image file derived from the medical image file (102) is generated by performing the motion correction based on the at least one unified frame file (110) using the processor (104). Subsequently, the at least one corrected image file is outputted for display to one or more display devices (122).
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