公开(公告)号：US20090253560A1

公开(公告)日：2009-10-08

申请号：US12061839

申请日：2008-04-03

Applicant: Arnold James Cook

Inventor： Arnold James Cook

IPC: A63B21/065

CPC classification number: A63B21/065 ,  A63B21/4007 ,  A63B43/005 ,  A63B69/0028

Abstract: A novel apparatus and method is disclosed for securing clothing or an object of weight against a body with one or more double locking securing wraps as well as overlapping double lock securing wraps. One lock is created between the edge of the object and the inside of the securing wrap while the other lock is created between the end of the wrap and the outside of the object or the outside of a securing wrap. Hook and loop fasteners are used to create the edge locks which prevent the object from sliding out from under the securing wrap. Weighted ankles, wrists, pants and vest system are also disclosed which incorporate the double locking system. The system allows for a wide range of size adjustability including the ability to add tension between the locks for additional security.

Abstract translation: 公开了一种新颖的装置和方法，用于通过一个或多个双重锁定固定包裹以及重叠的双重锁定固定包裹来将衣服或重物抵靠身体。 在对象的边缘和固定包装的内部之间创建一个锁，而另一个锁在包装的端部与物体的外部或固定包装的外部之间创建。 钩和环紧固件用于创建边缘锁，防止物体从固定包装下方滑出。 还公开了加重脚踝，手腕，裤子和背心系统，其中包含双锁定系统。 该系统允许宽范围的尺寸可调性，包括在锁之间增加张力以增加安全性的能力。

公开(公告)号：US07351566B2

公开(公告)日：2008-04-01

申请号：US11429599

申请日：2006-05-05

Applicant: Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Weich ,  Rajasekhar Bandaru

Inventor： Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Weich ,  Rajasekhar Bandaru

IPC: C12N9/12 ,  C12N5/00 ,  C07H21/04

CPC classification number: A61K38/16 ,  A01K2217/05 ,  A61K38/4813 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6416 ,  C12N9/6424 ,  C12N9/6491 ,  C12N9/93 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y603/02019 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/573 ,  G01N33/68 ,  G01N2500/10 ,  Y10T436/143333 ,  A61K2300/00

Abstract: The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。 本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及 已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。 本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20080024327A1

公开(公告)日：2008-01-31

申请号：US11695600

申请日：2007-04-02

Applicant: Trevor Downs ,  Shafer Taylor ,  Russell Stout ,  Jeffrey Jackson ,  Jason Jackson ,  James Cook

Inventor： Trevor Downs ,  Shafer Taylor ,  Russell Stout ,  Jeffrey Jackson ,  Jason Jackson ,  James Cook

IPC: H03K17/94 ,  H03M11/00

CPC classification number: H01H13/84 ,  G06F3/0202 ,  H01H2217/044 ,  H01H2229/054

Abstract: Keys of a keypad are configured to exhibit a wave-like vertical profile across a width of the keypad, thereby improving user comfort. Keys on the edge of the main grouping are raised, with the height of adjacent keys gradually reduced until a minimum (trough) is achieved. The height of the further adjacent keys is then increased until a maximum (peak) is achieved. In accordance with one embodiment, the keyboard includes two key troughs separated by an intervening raised key portion. The key troughs are positioned at the approximate location of hands resting on the home row of keys, for example in the case of a QWERTY keypad at the “D” key and at the “K” or “L” keys. The continuous, flowing change in the vertical profile of the keycaps renders the keyboard more accessible to the natural, relaxed state of the human hand, easing physical strain.

Abstract translation: 键盘的键被配置为在键盘的宽度上呈现波状的垂直轮廓，从而提高了用户的舒适度。 主组边缘的按键升高，相邻键的高度逐渐降低，直至达到最小（低谷）。 然后增加另外的相邻键的高度，直到达到最大值（峰值）。 根据一个实施例，键盘包括由中间凸起的键部分隔开的两个键槽。 关键槽定位在休息在主排键上的手的大致位置，例如在QWERTY键盘的情况下，在“D”键和“K”或“L”键处。 键帽的垂直轮廓的连续，流动的变化使得键盘更容易被人的手的自然，轻松的状态所接近，从而减轻了物理应变。

公开(公告)号：US20070299058A1

公开(公告)日：2007-12-27

申请号：US11767515

申请日：2007-06-24

Applicant: Xiaohui He ,  Xiaoyan Li ,  Jianming Yu ,  Dongmei Han ,  James Cook ,  Qi Huang

Inventor： Xiaohui He ,  Xiaoyan Li ,  Jianming Yu ,  Dongmei Han ,  James Cook ,  Qi Huang

IPC: A61K31/5517 ,  A61K31/5513 ,  A61P25/00 ,  C07D243/14

CPC classification number: C07D471/04 ,  C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.

Abstract translation: 公开了口服活性苯二氮卓衍生物及其盐。 这些化合物及其盐具有抗焦虑和抗惊厥活性，降低镇静/催眠/肌肉松弛/共济失调作用。

公开(公告)号：US20070114873A1

公开(公告)日：2007-05-24

申请号：US11285833

申请日：2005-11-22

Applicant: James Cook ,  Thomas Majernik

Inventor： James Cook ,  Thomas Majernik

IPC: G01C15/00 ,  H02K15/00 ,  G01B11/26 ,  B23K26/04

CPC classification number: G01B11/272 ,  G01C15/00 ,  H02K15/024

Abstract: In one embodiment the present invention provides for a method for checking the alignment of a stator core that comprises placing a laser source 14 and a target 18 a given distance apart on a stator core 10 and activating the laser such that the laser strikes the target. Then measuring on the target where the laser strikes, and interpreting the measurement to determine any misalignment of the stator core in the given distance.

Abstract translation: 在一个实施例中，本发明提供了一种用于检查定子芯的对准的方法，其包括将激光源14和靶18放置在定子芯10上一定距离，并激活激光使得激光撞击靶。 然后在激光撞击的目标上进行测量，并解释测量以确定给定距离内的定子芯的任何偏移。

公开(公告)号：US20070074579A1

公开(公告)日：2007-04-05

申请号：US11242271

申请日：2005-10-03

Applicant: James Cook ,  Alistair Bradley

Inventor： James Cook ,  Alistair Bradley

IPC: G01L9/12

CPC classification number: G01L9/0072 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A pressure sensor system includes a pressure sensing capacitor and an inductor integrated in a substrate. The pressure sensing capacitor includes a conductive diaphragm for detecting a pressure differential and an electrode separated from the diaphragm by a predetermined gap formed in the substrate. The inductor and pressure sensing capacitor form a passive inductive-capacitive (LC) tank circuit. A remote interrogation circuit, inductively coupled to the pressure sensor inductor coil, can be utilized to detect changes in resonant frequency of the LC tank wirelessly. The fully integrated pressure sensor structure is manufactured utilizing layer-by-layer fabrication techniques.

Abstract translation: 压力传感器系统包括压力感测电容器和集成在基板中的电感器。 压力感测电容器包括用于检测压差的导电隔膜和与隔膜形成在基板上的预定间隙隔开的电极。 电感和压力感应电容器形成无源感性电容（LC）电路。 感应耦合到压力传感器电感线圈的远程询问电路可以用于无线地检测LC箱的谐振频率的变化。 完全集成的压力传感器结构是利用逐层制造技术制造的。

公开(公告)号：US20070049580A1

公开(公告)日：2007-03-01

申请号：US11458855

申请日：2006-07-20

Applicant: James COOK ,  Qi Huang ,  Xiaohui He ,  Xioayan Li ,  Jianming Yu ,  Dongmei Han

Inventor： James COOK ,  Qi Huang ,  Xiaohui He ,  Xioayan Li ,  Jianming Yu ,  Dongmei Han

IPC: A61K31/551 ,  C07D487/12

CPC classification number: C07D471/04 ,  C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.

公开(公告)号：US20070039396A1

公开(公告)日：2007-02-22

申请号：US11210198

申请日：2005-08-22

Applicant: Scott Bunyer ,  Fred Hintz ,  Steven Magee ,  Randall Hasken ,  James Liu ,  Gary O'Brien ,  James Cook ,  Richard Andrews ,  Stephen Shiffer

Inventor： Scott Bunyer ,  Fred Hintz ,  Steven Magee ,  Randall Hasken ,  James Liu ,  Gary O'Brien ,  James Cook ,  Richard Andrews ,  Stephen Shiffer

IPC: G01N3/08

CPC classification number: G01L3/10

Abstract: A torque sensor packaging system and method includes a torque member that includes one or more holes formed therein for receiving one or more respective fasteners associated with a sensing element. The sensing element can be connected to the torque member to the sensing element in order to transfer torque associated with the torque member to the sensing element for torque sensing operations thereof.

Abstract translation: 扭矩传感器封装系统和方法包括扭矩构件，其包括形成在其中的一个或多个孔，用于接收与感测元件相关联的一个或多个相应紧固件。 感测元件可以连接到扭矩构件到感测元件，以便将与扭矩构件相关联的扭矩传递到用于其扭矩传感操作的感测元件。

公开(公告)号：US20060055286A1

公开(公告)日：2006-03-16

申请号：US10940275

申请日：2004-09-14

Applicant: Wayne Ehlers ,  Gary Eisenhower ,  Brian Marsh ,  James Cook

Inventor： Wayne Ehlers ,  Gary Eisenhower ,  Brian Marsh ,  James Cook

IPC: H01L41/08

CPC classification number: G01K11/265 ,  G01L9/0025 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/4913 ,  Y10T29/49144 ,  Y10T29/49155

Abstract: A surface acoustic wave die system and method are disclosed herein, including a surface acoustic wave sensor comprising one or more surface acoustic wave die disposed and hermetically sealed between a base and a cover. An adhesive is generally for securing one or more of the surface acoustic wave die to the base, which is configured with a pattern of cross hatches formed thereon in order to permit the adhesive to adhere to the base. The adhesive is placed under a location wherein surface acoustic wave die is to be located. The surface acoustic wave die is thereafter pressed into the adhesive, whereby upon a subsequent curing of the adhesive, the surface acoustic wave die is held securely in place, while remaining flexible as required by sensing applications associated with the surface acoustic save sensor.

Abstract translation: 本文公开了一种表面声波模头系统和方法，包括包括一个或多个表面声波芯片的声表面波传感器，其被设置并气密地密封在基座和盖子之间。 粘合剂通常用于将表面声波模具中的一个或多个固定到基部，该基底被构造成形成在其上的交叉影线图案，以便允许粘合剂粘附到基底上。 将粘合剂置于表面声波模头所在的位置。 然后将表面声波模具压入粘合剂中，由此在随后的粘合剂固化时，声表面波模具被牢固地保持就位，同时通过感测与表面声波保存传感器相关的应用，根据需要保持柔性。

公开(公告)号：US20060004011A1

公开(公告)日：2006-01-05

申请号：US10534215

申请日：2003-11-10

Applicant: Gaetan Ladouceur ,  Brian Bear ,  Cheng Bi ,  David Brittelli ,  Michael Burke ,  Gang Chen ,  James Cook ,  Jacques Dumas ,  Robert Sibley ,  Michael Turner

Inventor： Gaetan Ladouceur ,  Brian Bear ,  Cheng Bi ,  David Brittelli ,  Michael Burke ,  Gang Chen ,  James Cook ,  Jacques Dumas ,  Robert Sibley ,  Michael Turner

IPC: A61K31/498 ,  C07D43/14

CPC classification number: C07D403/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D475/00 ,  C07D487/04 ,  C07D491/056

Abstract: This invention relates to a compound of Formula I (I) and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.

Abstract translation: 本发明涉及式I（I）的化合物及其在治疗与血管生成相关的高增殖性疾病和疾病中的用途。