METHOD FOR OPTIMIZING THROUGHPUT OF A NETWORK

    公开(公告)号:US20170339058A1

    公开(公告)日:2017-11-23

    申请号:US15160043

    申请日:2016-05-20

    Abstract: A method for optimizing throughput of a network with stations adapted to transmit data to an access point includes the step of determining a respective required throughput for each station based on: respective time periods required for decreasing a count of a respective back-off counter associated with each of the stations, a transmission packet length of the respective station, and a probability of successful transmission for of the respective station. The respective required throughput so determined is a function of a respective transmission attempt rate for the station. The method further includes the step of determining the respective transmission attempt rate for each station for maximizing a sum of the respective required throughput such that a respective fixed throughput is provided for inelastic data flow in the network, a respective proportional throughput ratio is provided for elastic data flow in the network, and the throughput of the network is maximized.

    Oncogenic ROS1 and ALK kinase inhibitor

    公开(公告)号:US09782400B2

    公开(公告)日:2017-10-10

    申请号:US14956620

    申请日:2015-12-02

    CPC classification number: A61K31/4745

    Abstract: A compound suitable for treating cancer, in particular NSCLC, inhibits activity of oncogenic ROS1 kinase and ALK kinase. The compound has certain structural components such as a quinoline moiety in the backbone and at least one phenyl-containing moiety in a side chain with a hydrophobic substituent attached to the backbone via an up to 6-membered linking group as well as a further hydrophobic moiety. The presence of the structural components allows for an advantageous interaction with the ROS1 kinase domain and, further, with the ALK kinase domain. Hence, said compound represents a highly promising opportunity for patients bearing ROS1- or ALK-dependent cancer. A composition, in particular a pharmaceutical composition, includes the compound. A method for targeting cancer cells harboring an abnormality in ROS1 gene or ALK gene includes contacting a cell with the compound.

    Method for coding data
    165.
    发明授权

    公开(公告)号:US09755661B1

    公开(公告)日:2017-09-05

    申请号:US15238033

    申请日:2016-08-16

    CPC classification number: H03M7/3082 G09G5/02 G09G5/24 G10L19/018

    Abstract: A method for coding data includes: representing a first data in digital form as digital information; transforming the digital information into a first Gaussian integer; determining a relationship between the first Gaussian integer and a second Gaussian integer; and deriving, based on the determined relationship, a key for converting between the first Gaussian integer and the second Gaussian integer so as to associate the first data with a second data represented by the second Gaussian integer. The present invention also provides a system and a non-transient computer readable medium for implementing the method.

    NOVEL ROS1 INHIBITOR AND ITS USE
    170.
    发明申请

    公开(公告)号:US20170079972A1

    公开(公告)日:2017-03-23

    申请号:US14927825

    申请日:2015-10-30

    CPC classification number: A61K31/4743

    Abstract: The administration of a compound advantageously efficacious as ROS1 inhibitor and its effect on subjects with cancer includes administering a compound having certain structural components such as a quinoline moiety in the backbone and at least one tertiary amine containing moiety in a side chain as well as heteroatoms, in particular oxygen atoms, present in the backbone and the side chain for treating a subject suffering from a disease such as cancer. The presence of such structural components allows for an advantageous interaction with the ROS1 kinase domain, in particular with the hinge region. The administered compounds represent a highly promising opportunity in particular for patients bearing ROS1-dependent cancer. A method for targeting tumor cells harboring an abnormality in ROS1 gene includes contacting a cell with compounds of the present invention as well as pharmaceutical compositions comprising such compounds.

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