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    Novel Cryopreservation Bags and method of use thereof for Closed System, High Capacity Cell-Banking
    161.
    发明申请
    Novel Cryopreservation Bags and method of use thereof for Closed System, High Capacity Cell-Banking 有权
    新型冷冻保存袋及其封闭系统，高容量细胞库的使用方法

    公开(公告)号：US20160369225A1

    公开(公告)日：2016-12-22

    申请号：US14826720

    申请日：2015-08-14

    Applicant: Merial Inc.

    Inventor： Hervé François Coupier

    IPC: C12M1/00 ,  C12M1/12 ,  C12M1/34

    CPC classification number: C12M45/22 ,  A01N1/0268 ,  A61J1/10 ,  A61J1/1462 ,  A61J1/1475 ,  B01L3/505 ,  B01L9/00 ,  B01L2300/021 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/1894 ,  C12M23/14 ,  C12M23/26 ,  C12M37/00 ,  C12M37/02 ,  C12M37/04 ,  C12M41/44

    Abstract: The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train expansion. The bag is constructed principally of fluorinated ethylene propylene (FEP) fabric, and is designed to be filled such that the cell suspension has a very thin cross-section. The bag design includes at least an inlet conduit and an outlet or inoculation conduit, which can be sterilely welded to the source of the eukaryotic cells. The use of at least two sterile-weldable conduits allows for “closed system” filling of the bags, which significantly reduces the risk of contamination relative to other cell-banking methods. The bag also include a sleeve, which can be thermo-welded to form an enclosure, which protects the inlet and outlet conduits against contamination and mechanical damage during freezing, storage and subsequent thawing. In the method, once each bag is filled, its corresponding inlet conduit is sealed, and both the inlet and outlet conduits are enclosed within the bag's sleeve. This closed system method obviates the need for sterile environments (e.g. laminar flow unit).

    Abstract translation: 本公开提供了一种细胞冷冻和储存袋组件以及用于在银行真核细胞中使用该组件用于后续种子列扩展的方法。 该袋主要由氟化乙烯丙烯（FEP）织物构成，并且被设计成填充，使得细胞悬浮液具有非常薄的横截面。 袋设计包括至少一个入口管道和出口或接种管道，其可以无菌地焊接到真核细胞源。 使用至少两个无菌可焊接管道允许袋子的“封闭系统”填充，相对于其他细胞银行方法，这显着降低了污染的风险。 该袋还包括套筒，其可以被热焊接以形成外壳，其保护入口和出口管道免受冷冻，储存和随后解冻期间的污染和机械损坏。 在该方法中，一旦每个袋子被填充，其对应的入口管道被密封，并且入口和出口管道都被封装在袋子的套筒内。 这种封闭的系统方法消除了对无菌环境（例如层流单元）的需要。

    ANTIBIOTIC-FREE PLASMID
    163.
    发明申请
    ANTIBIOTIC-FREE PLASMID 审中-公开
    抗生素免费PLASMID

    公开(公告)号：US20160312231A1

    公开(公告)日：2016-10-27

    申请号：US14930710

    申请日：2015-11-03

    Applicant: MERIAL, INC.

    Inventor： Jean-Christophe Francis Audonnet ,  Edmond Jolivet

    IPC: C12N15/73 ,  C12N15/85 ,  C12P21/00 ,  C12N15/63

    Abstract: The present invention provides a method of maintaining a gram negative bacterium plasmid without the use of antibiotic selection pressure. Further, the invention relates to the drugless plasmids produced including drugless plasmids containing a heterologous gene. The invention also provides formulations and/or compositions comprising the drugless plasmids comprising a heterologous gene, formulations and/or compositions comprising a protein or an immunogen expressed using the drugless plasmids, and methods of administering such formulations and/or compositions to a host. The invention relates to gram negative bacteria containing the drugless plasmids.

    Abstract translation: 本发明提供了不使用抗生素选择压力来维持革兰氏阴性细菌质粒的方法。 此外，本发明涉及包含含有异源基因的无毒素质粒产生的无毒素质粒。 本发明还提供了包含含有异源基因，包含使用无药物质粒表达的蛋白质或免疫原的制剂和/或组合物的制剂和/或组合物的制剂和/或组合物，以及向宿主施用这些制剂和/或组合物的方法。 本发明涉及含有无毒素质粒的革兰氏阴性细菌。

    LONG-ACTING INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEROF
    165.
    发明申请
    LONG-ACTING INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEROF 审中-公开
    包含ISOXAZOLINE活性剂的长效注射剂配方，其方法和用途

    公开(公告)号：US20160256442A1

    公开(公告)日：2016-09-08

    申请号：US15054260

    申请日：2016-02-26

    Applicant: MERIAL, INC.

    Inventor： Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska

    IPC: A61K31/42 ,  A61K31/69 ,  A61K45/06 ,  A61K31/422 ,  A61K9/00 ,  A61K47/10

    Abstract: This invention relates to long-acting injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a poloxamer, and a co-solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the long-acting injectable formulations of the invention to the animal in need thereof.

    Abstract translation: 本发明涉及用于对抗动物寄生虫的长效注射制剂，其包含至少一种异恶唑啉活性剂，泊洛沙姆和共溶剂。 本发明还提供了用于消除，控制和预防动物中的寄生虫感染和侵染的改进方法，包括将本发明的长效注射制剂施用于有需要的动物。

    Method and Device for Conditional in ovo Injection
    168.
    发明申请
    Method and Device for Conditional in ovo Injection 审中-公开
    方法和装置有条件在ovo注射

    公开(公告)号：US20150327521A1

    公开(公告)日：2015-11-19

    申请号：US14716567

    申请日：2015-05-19

    Applicant: MERIAL, INC.

    Inventor： Christopher Davis Leslie ,  Chien Dinh Nguyen ,  Erich Bevensee

    IPC: A01K45/00 ,  A61D7/00 ,  A61D1/02 ,  A01K43/00 ,  A61M5/46

    CPC classification number: A01K45/007 ,  A01K43/00

    Abstract: The present invention provides in ovo injection devices, including a novel vaccine/substance conservation valve (VCV), a needle depth adjuster (NDA), and methods for selectively delivering vaccines and other substances to eggs in the context of poultry hatcheries. The valve of the present invention allows for the conditional dispensing of vaccines and other substances dependent upon the presence or absence of an egg. When an egg is present, the valve becomes activated, allowing vaccines or other substances to be injected. When an egg is absent, the valve is not activated, thus vaccines and other valuable substances are conserved. The NDA allows embryonated eggs to be more safely injected by reducing the depth of needle penetration, particularly in smaller eggs.

    Abstract translation: 本发明提供了包括新型疫苗/物质保存阀（VCV），针深度调节器（NDA）在内的ovo注射装置，以及在家禽孵化场的情况下选择性地将疫苗和其它物质输送到鸡蛋的方法。 本发明的阀允许根据蛋的存在或不存在来有条件地分配疫苗和其它物质。 当蛋存在时，阀被激活，允许注射疫苗或其他物质。 当鸡蛋不存在时，阀门不被激活，因此疫苗和其他有价值的物质是保守的。 NDA通过减少穿刺深度，特别是在较小的鸡蛋中，可以更加安全地注射胚胎蛋。

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