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    METHOD AND SYSTEM FOR DETECTING SUBSTANCE OF INTEREST IN SOLUTION
    172.
    发明申请
    METHOD AND SYSTEM FOR DETECTING SUBSTANCE OF INTEREST IN SOLUTION 有权

    公开(公告)号：US20210088461A1

    公开(公告)日：2021-03-25

    申请号：US16635363

    申请日：2018-07-05

    Applicant: Osaka University

    Inventor： Kazuyuki NOBUSAWA ,  Ichiro YAMASHITA

    IPC: G01N27/02 ,  C12Q1/686

    Abstract: The objective of the present invention is to provide a versatile method that makes highly sensitive detection of nucleic acid, and the like, possible even if a solution has a high salt concentration. This objective has been achieved through a method for detecting a target substance in a solution through EIS impedance measurement, wherein the solution includes at least the target substance, an impedance observation substance A, and a substance B for causing the charge mobility of the impedance observation substance to vary, and the substance B for causing the charge mobility to vary has a property of being taken into the target substance.

    THERAPEUTIC AGENT FOR NERVOUS SYSTEM DISEASE
    178.
    发明申请
    THERAPEUTIC AGENT FOR NERVOUS SYSTEM DISEASE 有权

    公开(公告)号：US20210008092A1

    公开(公告)日：2021-01-14

    申请号：US16907913

    申请日：2020-06-22

    Applicant: OSAKA UNIVERSITY ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

    Inventor： Hiroyuki TANAKA ,  Hideki YOSHIKAWA ,  Hideki MOCHIZUKI ,  Tsuyoshi MURASE ,  Tsutomu SASAKI ,  Kousuke BABA ,  Toru IWAHASHI ,  Mitsuru NAIKI

    IPC: A61K31/714 ,  A61K9/00 ,  A61P25/28

    Abstract: A method of treating a central nervous system disease, the method including administering an agent including a therapeutically effective amount of vitamin B12 to a patient with a central nervous system disease to treat the central nervous system disease. This disclosure also relates to a method of promoting M2 macrophage/microglia induction, inhibiting M1 macrophage/microglia induction, and/or reducing the ratio of M1 macrophage/microglia to M2 macrophage/microglia in a patient in need thereof, the method including administering an agent including a therapeutically effective amount of vitamin B12 to the patient to promote M2 macrophage/microglia induction, inhibit M1 macrophage/microglia induction, and/or reduce the ratio of M1 macrophage/microglia to M2 macrophage/microglia. This disclosure also relates to a pharmaceutical product including vitamin B12.

    GENE MUTATION ASSESSMENT DEVICE, ASSESSMENT METHOD, PROGRAM, AND STORAGE MEDIUM
    179.
    发明申请
    GENE MUTATION ASSESSMENT DEVICE, ASSESSMENT METHOD, PROGRAM, AND STORAGE MEDIUM 有权

    公开(公告)号：US20210005281A1

    公开(公告)日：2021-01-07

    申请号：US16976808

    申请日：2018-09-28

    Applicant: NEC Corporation ,  OSAKA UNIVERSITY

    Inventor： Masataka KIKUCHI ,  Akihiro NAKAYA

    IPC: G16B20/50 ,  G16H50/70 ,  G16B50/00

    Abstract: The present invention provides a new gene mutation assessment system which makes it possible, even when a gene mutation has considered to be apparently not associated with a trait from mutation information at a single position, to pick the gene mutation as a gene mutation candidate showing an association with the trait. The gene mutation assessment device (10) of the present invention includes a communication unit (19) that is capable of communicating a database DB, an assessment target mutation information acquisition unit (11) that acquires mutation information of a common gene mutation in a sample group showing a common trait as mutation information of an assessment target mutation, a score assignment unit (12) that assigns a first score showing an association with a trait of the DB information to the assessment target mutation based on the DB information, a score determination unit (13) that compares the first score with an association threshold and determines the assessment target mutation as a re-scoring target when the first score is less than the association threshold, a region mutation information acquisition unit (14) that acquires, as region mutation information, a gene mutation in an associated region with respect to a re-scoring target assessment target mutation based on the DB information, a score re-assignment unit (15) that assigns a second score weighted to the first score to the re-scoring target assessment target mutation based on the region mutation information, and an assessment score determination unit (16) that determines the second score as an assessment score of the re-scoring target assessment target mutation.

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