公开(公告)号：US20130303441A1

公开(公告)日：2013-11-14

申请号：US13982300

申请日：2012-01-26

Applicant: Hagit Eldar-Finkelman ,  Miriam Eisenstein

Inventor： Hagit Eldar-Finkelman ,  Miriam Eisenstein

IPC: C07K2/00

CPC classification number: C07K2/00 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C12N9/1205 ,  C12Y207/01037 ,  Y02A50/414

Abstract: Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are substrate-competitive inhibitors and have an amino acid sequence designed so as to bind to a defined binding site subunit in GSK-3.

Abstract translation: 公开了GSK-3的新型肽抑制剂，含有其的组合物及其用途。 新型肽抑制剂是​​底物竞争性抑制剂，并且具有设计成与GSK-3中规定的结合位点亚基结合的氨基酸序列。

公开(公告)号：US20130260386A1

公开(公告)日：2013-10-03

申请号：US13914686

申请日：2013-06-11

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Lior NISSIM ,  Roy Bar-Ziv

IPC: C12Q1/68

CPC classification number: C12Q1/6897 ,  C12N15/1055 ,  C12N15/85 ,  C12N2830/007 ,  C12N2830/008 ,  G01N33/5008 ,  G01N33/5091

Abstract: Nucleic acid construct systems are disclosed capable of diagnosing and treating a cell state (e.g. disease state). Methods of diagnosing and treating disease states using the nucleic acid constructs described herein are also disclosed. In addition, methods of screening for agents capable of reversing a disease phenotype using the nucleic acid constructs of the present invention are disclosed.

Abstract translation: 公开了能够诊断和治疗细胞状态（例如疾病状态）的核酸构建系统。 还公开了使用本文所述的核酸构建体诊断和治疗疾病状态的方法。 此外，公开了使用本发明的核酸构建体筛选能够逆转疾病表型的试剂的方法。

公开(公告)号：US08521272B2

公开(公告)日：2013-08-27

申请号：US12863604

申请日：2009-01-21

Applicant: Ruti Kapon ,  Arik Peled ,  Shahar Seifer ,  Revital Schneider

Inventor： Ruti Kapon ,  Arik Peled ,  Shahar Seifer ,  Revital Schneider

IPC: A61B5/053

CPC classification number: A61B5/0531 ,  A61B5/0535 ,  A61B5/4288 ,  A61B5/4312

Abstract: A method of monitoring amount of milk consumed by an infant being breastfed by a breast is disclosed. The method comprises: determining variations in electric capacitance of the breast during breastfeeding, and correlating the electric capacitance variations to an amount of milk consumed by the infant.

公开(公告)号：US20130198900A1

公开(公告)日：2013-08-01

申请号：US13821343

申请日：2011-09-07

Applicant: Asaph Aharoni ,  Samuel Bocobza ,  Michal Shapira

Inventor： Asaph Aharoni ,  Samuel Bocobza ,  Michal Shapira

IPC: C12N15/82

CPC classification number: C12N15/8243 ,  C12N9/1085 ,  C12N9/12 ,  C12N15/8217 ,  C12Y207/06002

Abstract: The present invention provides bioengineered organisms producing elevated levels of thiamine and/or thiamine derivatives. Particularly, the present invention discloses that modifying TPP-responsive riboswitch results in accumulation of thiamine and/or its derivatives.

Abstract translation: 本发明提供了产生升高水平的硫胺素和/或硫胺素衍生物的生物工程生物。 特别地，本发明公开了改性TPP反应性核糖开关导致硫胺素和/或其衍生物的积累。

公开(公告)号：US20130183322A1

公开(公告)日：2013-07-18

申请号：US13821269

申请日：2011-09-08

Applicant: Yair Reisner ,  Esther Bachar-Lustig ,  Dalit Tchorsh-Yutsis

Inventor： Yair Reisner ,  Esther Bachar-Lustig ,  Dalit Tchorsh-Yutsis

IPC: A61K39/395 ,  A61K35/26 ,  A61K35/28

CPC classification number: A61K39/3955 ,  A61K35/26 ,  A61K35/28 ,  A61K38/1774 ,  A61K2035/122 ,  A61K2300/00

Abstract: A method of treating a subject in need of a cell or tissue transplant is disclosed. The method comprising (a) transplanting a non-syngeneic cell or tissue transplant into the subject, wherein the transplant comprises bone marrow or lymphoid cells; and (b) administering to the subject a therapeutically effective amount of an immunosuppressive regimen comprising a Sphingosine 1-Phosphate Receptor Agonist, a B7 molecule inhibitor and a CD2/CD58 pathway inhibitor, thereby treating the subject.

Abstract translation: 公开了一种治疗需要细胞或组织移植的受试者的方法。 所述方法包括（a）将非同基因细胞或组织移植移植到所述受试者中，其中所述移植物包含骨髓或淋巴样细胞; 和（b）向受试者施用治疗有效量的包含1-鞘氨醇鞘氨醇受体激动剂，B7分子抑制剂和CD2 / CD58途径抑制剂的免疫抑制方案，从而治疗受试者。

公开(公告)号：US20130098440A1

公开(公告)日：2013-04-25

申请号：US13807597

申请日：2011-06-29

Applicant: Gary Hodes ,  Eran Edri ,  Elena Rabinovich

Inventor： Gary Hodes ,  Eran Edri ,  Elena Rabinovich

IPC: H01L51/00 ,  H01L51/42

CPC classification number: H01L51/0002 ,  C03C17/347 ,  C03C17/3476 ,  C03C2218/32 ,  H01G9/204 ,  H01G9/2054 ,  H01L31/022483 ,  H01L31/03529 ,  H01L31/073 ,  H01L31/1884 ,  H01L51/4213 ,  Y02E10/542 ,  Y02E10/543 ,  Y02P70/521

Abstract: A method is presented for use in manufacture of a semiconductor device, such as a photovoltaic cell. The method comprises: providing a structure comprising a ZnO layer; applying a surface treatment to said structure for a certain time period to form a layer of ZnS on said ZnO layer; and depositing an active structure on said ZnS layer. The active structure may be a light absorbing structure, including a light absorbing semiconductor or a molecular light absorbing dye. The provision of the ZnS buffer layer between the ZnO layer and the active structure improves the device performance.

Abstract translation: 提出了一种用于制造诸如光伏电池的半导体器件的方法。 该方法包括：提供包括ZnO层的结构; 对所述结构施加表面处理一定时间以在所述ZnO层上形成ZnS层; 以及在所述ZnS层上沉积活性结构。 活性结构可以是光吸收结构，包括光吸收半导体或分子吸光染料。 在ZnO层和活性结构之间提供ZnS缓冲层提高了器件性能。

公开(公告)号：US08357789B2

公开(公告)日：2013-01-22

申请号：US12585600

申请日：2009-09-18

Applicant: Ruth Arnon ,  Sung-Ho Jeon ,  Basak Kayhan ,  Tamar Ben-Yedidia

Inventor： Ruth Arnon ,  Sung-Ho Jeon ,  Basak Kayhan ,  Tamar Ben-Yedidia

IPC: C07H21/02 ,  C07H21/04 ,  C07H21/00 ,  A01N43/04 ,  A61K31/70

CPC classification number: C07H21/04 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/322 ,  G01N33/56983 ,  G01N2333/11

Abstract: Polynucleotides and polypeptides which participate in influenza virus infection of cells and nucleic acid molecules, which include a polynucleotide sequence capable of specifically binding the polypeptides of the present invention. Also provided are methods of using such nucleic acid molecules, polynucleotides and antibodies directed thereagainst for diagnosing, treating and preventing influenza virus infection.

公开(公告)号：US20120319498A1

公开(公告)日：2012-12-20

申请号：US13582512

申请日：2011-03-03

Applicant: Yaron Silberberg ,  Haim Suchowski ,  Nikolay V. Vitanov ,  Andon A. Rangelov

Inventor： Yaron Silberberg ,  Haim Suchowski ,  Nikolay V. Vitanov ,  Andon A. Rangelov

IPC: H01F38/14

CPC classification number: H02J50/12 ,  H01F38/14 ,  H02J5/005

Abstract: A method or apparatus for transferring energy between a source coil and a drain coil, comprises setting an initial resonant frequency of the source coil as a first condition; setting the source coil and said drain coil in positions relative to each other to define an initial coupling coefficient therebetween, so that the initial coupling coefficient comprises a second condition; and adiabatically changing one or both of the conditions while pumping energy into the source coil. The source coil energy is transferred to the drain coil over the course of the adiabatic change.

Abstract translation: 一种用于在源极线圈和漏极线圈之间传送能量的方法或装置，包括将源极线圈的初始谐振频率设置为第一条件; 将源极线圈和所述漏极线圈设置在相对于彼此的位置以限定其间的初始耦合系数，使得初始耦合系数包括第二条件; 并绝热地改变一个或两个条件，同时将能量泵入源线圈。 在绝热变化的过程中，源极线圈能量被传递到漏极线圈。

公开(公告)号：US20120316106A1

公开(公告)日：2012-12-13

申请号：US13519862

申请日：2010-12-29

Applicant: Ada Yonath ,  Chen Davidovich ,  Ella Zimmerman ,  Anat Bashan ,  Tamar Auerbach ,  Matthew Belousoff ,  Liqun Xiong ,  Dorota Klepacki ,  Alexander S. Mankin

Inventor： Ada Yonath ,  Chen Davidovich ,  Ella Zimmerman ,  Anat Bashan ,  Tamar Auerbach ,  Matthew Belousoff ,  Liqun Xiong ,  Dorota Klepacki ,  Alexander S. Mankin

IPC: A61K31/7048 ,  A61K31/424 ,  A61K38/12 ,  A61P31/04 ,  A61K31/165 ,  A61K31/7056 ,  C07H17/08 ,  A61K31/366 ,  A61K31/215

CPC classification number: A61K31/365 ,  A61K31/424 ,  A61K31/7048 ,  A61K38/08 ,  A61K2300/00

Abstract: Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions that include these improved analogs and synergistic combinations, along with methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.

Abstract translation: 提供改进的抗生素类似物，以及基于结构晶体学分析设计的抗生素的协同组合以及包括这些改进的类似物和协同组合以及其生产和使用方法的药物组合物。 协同组合靶向核糖体中的相邻位点，证明相应的核糖体位点用于开发临床相关的协同抗生素的重要性。

公开(公告)号：US20120197033A1

公开(公告)日：2012-08-02

申请号：US13499715

申请日：2010-09-19

Applicant: Ronny Neumann ,  Delina Barats

Inventor： Ronny Neumann ,  Delina Barats

IPC: C07C45/38 ,  C07F15/00

CPC classification number: C07F11/005 ,  B01J23/6527 ,  C07C45/29 ,  C07C45/38 ,  C07F15/0066 ,  C07C47/02 ,  C07C47/21

Abstract: A process of oxidizing primary alcohols to their corresponding aldehydes is disclosed. The process is effected in the presence of noble metal polyoxometalate complexes. A novel process for preparing noble metal polyoxometalate complexes, and novel noble metal polyoxometalate complexes are also disclosed.

Abstract translation: 公开了将伯醇氧化为相应的醛的方法。 该方法在贵金属多金属氧酸盐络合物的存在下进行。 还公开了一种制备贵金属多金属氧酸盐络合物的新方法，以及新颖的贵金属多金属氧酸盐络合物。