Abstract:
6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.
Abstract:
The present invention provides a method for blocking a protocol message at a Sub-ring control channel without a virtual channel, for avoiding the problem that the Sub-ring is in a continuous refresh state all the time caused by the existing solution of the Sub-ring control channel without the virtual channel, and the method includes: blocking forwarding of relevant messages when a forced switch is initiated or a failure is detected.
Abstract:
Methods and apparatuses are provided that facilitate providing an object-based transport protocol that allows transmission of arbitrarily sized objects over a network protocol layer. The object-based transport protocol can also provide association of metadata with the objects to control communication thereof, and/or communication of response objects. Moreover, the object-based transport protocol can maintain sessions with remote network nodes that can include multiple channels, which can be updated over time to seamlessly provide mobility, increased data rates, and/or the like. In addition, properties can be modified remotely by network nodes receiving objects related to the properties.
Abstract:
This invention relates to novel compositions comprising regioselectively substituted cellulose esters. One aspect of the invention relates to processes for preparing regioselectively substituted cellulose esters from cellulose dissolved in ionic liquids. Another aspect of the invention relates to the utility of regioselectively substituted cellulose esters in applications such as protective and compensation films for liquid crystalline displays.
Abstract:
This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
Abstract:
The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Abstract:
This invention relates to novel compounds having the formula (I); and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
Abstract:
A seat belt retractor for use in seat belt restraint systems. The retractor incorporates dual rotopretensioner units and adaptive load limiting characteristics. Preferably, the rotopretensioners are positioned on opposite ends of a retractor spool for driving the spool for pretensioning rotation. A first pretensioner may be activated alone to provide pretensioning rotation. In one embodiment of the invention, if the second pretensioner is not activated, the system will be engaged to provide a given belt load limiting characteristic. A second rotopretensioner may be fired either after the first pretensioner is fired to increase pay-in capacity or to activate a different load limiting characteristic for the retractor.
Abstract:
A block-request streaming system provides for improvements in the user experience and bandwidth efficiency of such systems, typically using an ingestion system that generates data in a form to be served by a conventional file server (HTTP, FTP, or the like), wherein the ingestion system intakes content and prepares it as files or data elements to be served by the file server. The system might include controlling the sequence, timing and construction of block requests, time based indexing, variable block sizing, optimal block partitioning, control of random access point placement, including across multiple presentation versions, dynamically updating presentation data, and/or efficiently presenting live content and time shifting.