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    Determining onset of cardiac depolarization and repolarization waves for signal processing
    183.
    发明授权
    Determining onset of cardiac depolarization and repolarization waves for signal processing 有权

    公开(公告)号：US09737223B2

    公开(公告)日：2017-08-22

    申请号：US14815506

    申请日：2015-07-31

    Applicant: Medtronic, Inc.

    Inventor： Juan Du ,  Subham Ghosh

    IPC: A61B5/0402 ,  A61B5/04 ,  A61B5/0408 ,  A61B5/00 ,  A61B5/0452 ,  A61B5/044 ,  A61N1/365

    CPC classification number: A61B5/04012 ,  A61B5/04085 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/7239 ,  A61B5/7282 ,  A61N1/36507

    Abstract: A system and associated method is disclosed for determining whether signal is valid. The system comprises an electrode apparatus comprising a plurality of electrodes configured to be located proximate tissue of a patient. A display apparatus comprising a graphical user interface, wherein the graphical user interface is configured to present information to a user. A computing apparatus coupled to the electrode apparatus and display apparatus, wherein the computing apparatus is configured to determine whether a signal acquired from a channel associated with an electrode from the plurality of electrodes is valid and sufficiently strong by i) calculating a first derivative of the signal; ii) determining a minimum and maximum derivative from the first derivative; iii) determining whether signs of the minimum and maximum derivative are different; and in response to determining whether the signs of the minimum and maximum derivative are different, displaying on a display apparatus whether the signal is valid.

    Closed loop optimization of control parameters during cardiac pacing
    184.
    发明授权
    Closed loop optimization of control parameters during cardiac pacing 有权

    公开(公告)号：US09649497B2

    公开(公告)日：2017-05-16

    申请号：US15062945

    申请日：2016-03-07

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh

    IPC: A61N1/36 ,  A61N1/368 ,  A61N1/362

    CPC classification number: A61N1/3682 ,  A61N1/3627 ,  A61N1/3684

    Abstract: A system and method control a pacing parameter in a closed-loop manner by determining a value of an EGM-based index corresponding an optimal electrical activation condition of a patient's heart and adjusting a pacing therapy to maintain the EGM-based index value. The closed loop control method performed by the system may establish a relationship between an EGM-based index and multiple settings of a pacing control parameter. Values of the EGM-based index are stored with corresponding setting shifts relative to a previously established optimal setting. A processor of an implantable medical device monitors the EGM-based index during cardiac pacing. Responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, the processor determines an adjustment of the control parameter from the stored index values and corresponding setting shifts.

    CAPTURE MANAGEMENT DURING LEFT VENTRICULAR PACING THERAPY IN A CARDIAC MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM
    185.
    发明申请
    CAPTURE MANAGEMENT DURING LEFT VENTRICULAR PACING THERAPY IN A CARDIAC MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM 审中-公开
    心脏医疗器械和医疗器械系统中的左心室淋巴结治疗期间的收集管理

    公开(公告)号：US20170028206A1

    公开(公告)日：2017-02-02

    申请号：US15221995

    申请日：2016-07-28

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh

    IPC: A61N1/37 ,  A61N1/375 ,  A61B5/042 ,  A61N1/365 ,  A61N1/368

    CPC classification number: A61N1/3684 ,  A61B5/042 ,  A61B5/04525 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/4836 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/3682 ,  A61N1/3688 ,  A61N1/371 ,  A61N1/3712 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3956

    Abstract: A medical device and medical device system for determining capture during delivery of a ventricular pacing therapy that includes a subcutaneous sensing device comprising a subcutaneous electrode to sense a subcutaneous cardiac signal and to emit a trigger signal in response to the sensed cardiac signal, an intracardiac therapy delivery device capable of being implanted within a left ventricle of a heart to receive the trigger signal and deliver the ventricular pacing therapy to the left ventricle in response to the emitted trigger signal, and a processor positioned within the subcutaneous sensing device, the processor configured to compare a beat of the subcutaneous cardiac signal sensed by the sensing device subsequent to the ventricular pacing therapy being delivered to a baseline template associated with a non-paced beat, and determine whether the delivered ventricular pacing therapy captures the left ventricle in response to the comparing.

    Abstract translation: 一种医疗装置和医疗装置系统，用于在递送心室起搏治疗期间确定捕获，其包括皮下感测装置，所述皮下感测装置包括用于感测皮下心脏信号的皮下电极并响应于所感测到的心脏信号而发出触发信号，心内治疗 输送装置能够植入心脏的左心室以接收触发信号并响应于所发射的触发信号将心室起搏治疗递送到左心室，以及位于皮下感测装置内的处理器，其被配置为 将心室起搏治疗之后的感测装置感测到的皮下心脏信号的搏动递送到与非节奏搏动相关联的基线模板，并且确定所输送的心室起搏疗法是否响应于比较来捕获左心室 。

    BIOELECTRIC SENSOR DEVICE AND METHODS
    186.
    发明申请
    BIOELECTRIC SENSOR DEVICE AND METHODS 审中-公开

    公开(公告)号：US20160220142A1

    公开(公告)日：2016-08-04

    申请号：US15095661

    申请日：2016-04-11

    Applicant: Medtronic, Inc.

    Inventor： Jeffrey Gillberg ,  Subham Ghosh

    IPC: A61B5/0408 ,  A61B5/00

    CPC classification number: A61B5/04085 ,  A61B5/04 ,  A61B5/04087 ,  A61B5/6805 ,  A61B5/6823 ,  A61B5/683 ,  A61B5/6832 ,  A61B5/68335 ,  A61B2562/046 ,  A61B2562/164

    Abstract: Various embodiments of a bioelectric sensor device for sensing bioelectric data from a human body are disclosed. The device can include a flexible substrate, a plurality of sensors arranged in a sensor array on a sensor array portion of the substrate, an electrically conductive network located on the substrate, and a plurality of lines of weakness formed in the sensor array portion of the substrate. In one or more embodiments, each line of weakness is configured to enhance separation of the sensor array portion of the substrate along a separation line that extends between at least two sensors of the plurality of sensors. The device can also include a left reference electrode proximate a distal end of a left reference electrode arm of the substrate and a right reference electrode proximate a distal end of a right reference electrode arm of the substrate.

    Anodal capture detection
    188.
    发明授权
    Anodal capture detection 有权
    阳极捕获检测

    公开(公告)号：US09254392B2

    公开(公告)日：2016-02-09

    申请号：US14145053

    申请日：2013-12-31

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Todd Sheldon

    IPC: A61N1/37 ,  A61N1/362

    CPC classification number: A61N1/371 ,  A61N1/362

    Abstract: Systems and methods are described herein for determining whether anodal capture of the right ventricle is occurring when delivering left ventricular pacing with a cross-chamber pacing vector. The systems and methods may be measure cross-chamber sense times from left ventricular pacing and right ventricular pacing and compare the cross-chamber sense times to determine whether anodal capture of the right ventricle is occurring.

    Abstract translation: 本文描述了系统和方法，用于确定当用横向室起搏向量递送左心室起搏时是否发生右心室的阳极捕获。 系统和方法可以测量来自左心室起搏和右心室起搏的交叉室感测时间，并且比较横室感测时间以确定是否正在发生右心室的阳极捕获。

    SYSTEMS AND METHODS FOR EVALUATING CARDIAC THERAPY
    189.
    发明申请
    SYSTEMS AND METHODS FOR EVALUATING CARDIAC THERAPY 有权
    用于评估心脏病治疗的系统和方法

    公开(公告)号：US20160030751A1

    公开(公告)日：2016-02-04

    申请号：US14695412

    申请日：2015-04-24

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Jeffrey Gillberg

    IPC: A61N1/365

    CPC classification number: A61B5/04085 ,  A61B5/4833 ,  A61B2562/046 ,  A61N1/3627 ,  A61N1/37 ,  A61N1/372 ,  A61N1/3956

    Abstract: Systems and methods are described herein for assisting a user in evaluation of cardiac therapy. The systems and methods may monitor electrical activity of a patient using external electrode apparatus to provide baseline cardiac information and therapy cardiac information and determine whether the cardiac pacing, or therapy, location is acceptable. If the cardiac pacing, or therapy, location is unacceptable, location information representative of a location that may more effective may be generated based on the therapy cardiac information.

    Abstract translation: 本文描述了用于帮助用户评估心脏治疗的系统和方法。 系统和方法可以使用外部电极装置监测患者的电活动，以提供基线心脏信息和治疗心脏信息，并确定心脏起搏或治疗位置是否可接受。 如果心脏起搏或治疗位置是不可接受的，则可以基于治疗心脏信息产生代表可能更有效的位置的位置信息。

    ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS
    190.
    发明申请
    ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS 有权
    评估心脏内膜激活模式

    公开(公告)号：US20150216434A1

    公开(公告)日：2015-08-06

    申请号：US14635498

    申请日：2015-03-02

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Jeffrey M. Gillberg ,  Robert W. Stadler

    IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0402

    CPC classification number: A61B5/04012 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/05 ,  A61B5/742 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    Abstract: Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

    Abstract translation: 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。

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