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40 条记录 (耗时 0.033 秒)

    USE OF GDF-5 FOR THE IMPROVEMENT OR MAINTENANCE OF DERMAL APPEARANCE
    17.
    发明申请
    USE OF GDF-5 FOR THE IMPROVEMENT OR MAINTENANCE OF DERMAL APPEARANCE 审中-公开
    使用GDF-5改善或维持皮肤外观

    公开(公告)号：US20100047299A1

    公开(公告)日：2010-02-25

    申请号：US12524229

    申请日：2008-01-24

    申请人： Jens Pohl

    发明人： Jens Pohl

    IPC分类号： A61K8/02 ,  A61K38/39 ,  A61K31/7088 ,  A61K31/715 ,  A61Q19/08

    CPC分类号： C07K14/51 ,  A61K8/606 ,  A61K8/64 ,  A61Q19/08

    摘要： The present invention is directed to novel methods and compositions containing growth factor proteins. Said compositions are specifically designed to optimize the amount of crucial structural elements of mammalian tissues. The invention is especially useful for the preservation and improvement of dermal tissue appearance.

    摘要翻译： 本发明涉及含有生长因子蛋白质的新方法和组合物。 所述组合物被特别设计用于优化哺乳动物组织的关键结构元件的量。 本发明对皮肤组织外观的保存和改善特别有用。

    Cartilage/Bone inducing materials for preparation
    18.
    发明授权
    Cartilage/Bone inducing materials for preparation 失效
    软骨/骨诱导材料制备

    公开(公告)号：US07238657B2

    公开(公告)日：2007-07-03

    申请号：US10885099

    申请日：2004-07-07

    申请人： Takesada Shimura ,  Satsuki Toriyama

    发明人： Takesada Shimura ,  Satsuki Toriyama

    IPC分类号： A61K38/17 ,  A61K38/00

    CPC分类号： A61L27/227 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61K38/1875 ,  C07K14/51

    摘要： A cartilage and bone morphogenetic repairing composition which contains a bone morphogenetic protein and a polyoxyethylene-polyoxypropylene glycol is disclosed. It is preferable that the molecular weight of a polyoxypropylene, i.e., a component of said polyoxyethylene-polyoxypropylene glycol, is in the range of about 1,500-4,000 and the weight ratio of ethylene oxide is in the range of 40-80%/molecule, and a concentration of said polyoxyethylene-polyoxypropylene glycol in an aqueous solution is about 10-50%. The composition may be applied in a cartilage and bone morphogenetic method without a surgical operation and comprises a bone morphogenetic protein and a carrier which has a high bio-absorption, a good affinity to the bone morphogenetic protein and is capable of temperature dependent gel-sol reversible transition. The composition may conveniently be applied locally to the site of a bone fracture or bone defect.

    摘要翻译： 公开了含有骨形态发生蛋白和聚氧乙烯 - 聚氧丙烯二醇的软骨和骨形态发生修复组合物。 优选聚氧丙烯的分子量，即所述聚氧乙烯 - 聚氧丙烯二醇的组分在约1,500-4,000的范围内，环氧乙烷的重量比在40-80％/分子的范围内， 所述聚氧乙烯 - 聚氧丙烯二醇在水溶液中的浓度为约10-50％。 该组合物可以在没有手术操作的软骨和骨形态发生方法中应用，并且包括骨形态发生蛋白和具有高生物吸收，对骨形态发生蛋白具有良好亲和力并且能够依赖于温度的凝胶溶胶 可逆转换 组合物可以方便地局部施用于骨折或骨缺损的部位。

    DNA sequences encoding novel growth/differentiation factors
    19.
    发明申请
    DNA sequences encoding novel growth/differentiation factors 审中-公开
    编码新生长/分化因子的DNA序列

    公开(公告)号：US20070031351A1

    公开(公告)日：2007-02-08

    申请号：US11545480

    申请日：2006-10-11

    申请人： Gertrud Hoetten ,  Helge Neidhardt ,  Rolf Bechtold ,  Jens Pohl

    发明人： Gertrud Hoetten ,  Helge Neidhardt ,  Rolf Bechtold ,  Jens Pohl

    IPC分类号： A61K8/96

    CPC分类号： A61K38/1858 ,  A61K38/00 ,  A61K38/1808 ,  C07K14/495 ,  C07K14/51

    摘要： The invention provides DNA sequences encoding novel members of the TGF-β family of proteins. The. TGF-β family comprises proteins which function as growth and/or differentiation factors and which are useful in medical applications. Accordingly, the invention also describes the isolation of the above-mentioned DNA sequences, the expression of the encoded proteins, the production of said proteins and pharmaceutical compositions containing said proteins.

    摘要翻译： 本发明提供编码TGF-β蛋白家族的新成员的DNA序列。 的。 TGF-β家族包含用作生长和/或分化因子并且可用于医学应用的蛋白质。 因此，本发明还描述了上述DNA序列的分离，编码蛋白质的表达，所述蛋白质的产生和含有所述蛋白质的药物组合物。

    Neuroprotective properties of GDF-15, a novel member of the TGF-Beta superfamily
    20.
    发明申请
    Neuroprotective properties of GDF-15, a novel member of the TGF-Beta superfamily 审中-公开
    GDF-15，TGF-β超家族的新成员的神经保护性质

    公开(公告)号：US20060148709A1

    公开(公告)日：2006-07-06

    申请号：US11372281

    申请日：2006-03-09

    申请人： Klaus Unsicker ,  Kerstin Krieglstein

    发明人： Klaus Unsicker ,  Kerstin Krieglstein

    IPC分类号： A61K48/00 ,  A61K38/18

    CPC分类号： C07K14/495

    摘要： The present invention relates to a transforming growth factor-beta (TGF-β)-like protein which is derived from neurons and glial cells, and which has a neurotrophic effect on dopaminergic (DAergic) neurons, to nucleic acids coding for the protein, to a vector containing the nucleic acids, to host organisms containing the nucleic acids or the vector, to antibodies directed against the protein, to methods for the production of the nucleic acids, the vector or the protein, to a pharmaceutical composition for the treatment of neurodegenerative disorders in mammals and to a diagnostic kit for the detection of said disorders.

    摘要翻译： 本发明涉及衍生自神经元和神经胶质细胞的转化生长因子-β（TGF-β）样蛋白，其对多巴胺能（DAergic）神经元具有神经营养作用，编码蛋白质的核酸， 将含有核酸的载体，将含有核酸或载体的生物载体引导至针对该蛋白质的抗体，将生产核酸载体或蛋白质的方法用于治疗神经变性的药物组合物 哺乳动物的疾病以及用于检测所述疾病的诊断试剂盒。