公开(公告)号：US20250163369A1

公开(公告)日：2025-05-22

申请号：US18836633

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： Masahiro KINOOKA ,  Meehae KIM ,  Yukako FUJINAGA

IPC: C12N5/071 ,  C12N5/00

Abstract: An agent for directional control of differentiation induction of a pluripotent stem cell, which contains an E-cadherin inhibitor, and its uses are disclosed. A method for controlling the directionality of differentiation induction of a pluripotent stem cell is also disclosed. The method includes a step of culturing a pluripotent stem cell in a medium comprising an E-cadherin inhibitor.

公开(公告)号：US20250146145A1

公开(公告)日：2025-05-08

申请号：US18839756

申请日：2023-02-22

Applicant: OSAKA UNIVERSITY ,  IDEMITSU KOSAN CO., LTD.

Inventor： Kazuhide KAMIYA ,  Rino SUGIMOTO ,  Qingxin JIA ,  Hiroyuki KANEKO

IPC: C25B9/23 ,  C25B3/26 ,  C25B11/032 ,  C25B11/037 ,  C25B11/065 ,  C25B11/091 ,  C25B13/05

Abstract: A catalyst that has a high electrolytic activity and a high CO2 reduction reaction rate and a method of producing the same, a cathode, an ion exchange membrane-electrode assembly, and a solid electrolyte electrolysis apparatus are provided. The catalyst includes a metal ion selected from the group consisting of a copper ion, a nickel ion, an iron ion, a cobalt ion, a zinc ion, a manganese ion, a molybdenum ion, and an aluminum ion, a nitrogen-containing compound, and a carrier containing carbon having a primary particle diameter of 5 to 200 nm, the metal ion is coordinated to the nitrogen atom on the nitrogen-containing compound, the catalyst has a content of the metal ion coordinated to the nitrogen atom of 0.7% by mass or more, and the catalyst has a particle diameter of 10 nm to 50 μm.

公开(公告)号：US20250129514A1

公开(公告)日：2025-04-24

申请号：US18990573

申请日：2024-12-20

Applicant: PANASONIC HOLDINGS CORPORATION ,  OSAKA UNIVERSITY

Inventor： Tomio YAMASHITA ,  Yoshio OKAYAMA ,  Yusuke MORI ,  Masashi YOSHIMURA ,  Masayuki IMANISHI ,  Kousuke MURAKAMI

IPC: C30B25/20 ,  C30B29/40 ,  C30B29/66

Abstract: A method for manufacturing a Group III nitride crystal, the method including: bringing a surface of a Group III nitride seed crystal into contact with a melt including at least one Group III element selected from among gallium, aluminum, and indium and an alkali metal in an atmosphere containing nitrogen to cause the Group III element and the nitrogen to react with each other in the melt to grow a Group III nitride crystal on the Group III nitride seed crystal, the method includes: growing a plurality of island-like Group III nitride crystal nuclei on the surface of the Group III nitride seed crystal; growing a first Group III nitride crystal having an inverted triangular shape or a trapezoidal shape in section from each of the plurality of island-like Group III nitride crystal nuclei; and growing a second Group III nitride crystal such that the second Group III nitride crystal fills a depression of the first Group III nitride crystal to form the second Group III nitride crystal having a flat surface, wherein in the course of growing the plurality of island-like Group III nitride crystal nuclei, a temperature is set to 875° C. or more and a nucleation density is set to 1*106/cm2 or less, and in the course of growing the first Group III nitride crystal and growing the second Group III nitride crystal, immersion of the Group III nitride seed crystal in the melt and pulling up from the melt are repeated a plurality of times.

公开(公告)号：US12272459B2

公开(公告)日：2025-04-08

申请号：US17493856

申请日：2021-10-05

Applicant: Topcon Corporation ,  Osaka University

Inventor： Kohji Nishida ,  Atsuya Miki ,  Kazuichi Maruyama ,  Ryo Kawasaki ,  Song Mei ,  Zaixing Mao ,  Zhenguo Wang ,  Kinpui Chan ,  Xin Sui

IPC: G06T7/12 ,  G06T7/10 ,  G06T15/08 ,  G16H50/20 ,  G16H50/30

Abstract: A medical diagnostic apparatus includes a receiver circuit that receives three-dimensional data of a subject's eye, and a processor configured to separate portions of the three-dimensional data into separate segments, perform processing differently on each of the separate segments, and combine the separately processed segments to produce a segmented three-dimensional data set. The processor is further configured to generate at least one diagnostic metric from the segmented three-dimensional data set, and the processor is further configured to evaluate a pathological condition based on the at least one diagnostic metric. Related methods and computer readable media are also disclosed.

公开(公告)号：US12259379B2

公开(公告)日：2025-03-25

申请号：US16626683

申请日：2018-06-29

Applicant: OSAKA UNIVERSITY

Inventor： Kota Iwahori ,  Hisashi Wada

IPC: G01N33/50 ,  A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  G01N33/53 ,  G01N33/574 ,  G16B50/30 ,  G16H50/30 ,  A61K39/00

Abstract: An object of the present invention is to provide a companion diagnostic for predicting the effect of a tumor immunotherapy. The effect of a tumor immunotherapy is predicted by a method including step 1: contacting directly or indirectly peripheral blood mononuclear cells collected from a patient who is a target for treatment of a malignant tumor with tumor cells in vitro; step 2: determining whether the tumor cells that contacted with the peripheral blood mononuclear cells in step 1 are damaged; and step 3: determining that the tumor immunotherapy is effective against the malignant tumor in the patient when the tumor cells are determined to have been damaged in step 2.

公开(公告)号：US20250076299A1

公开(公告)日：2025-03-06

申请号：US18520251

申请日：2022-03-31

Applicant: MICAN Technologies Inc. ,  Japan as Represented by the Director-General of National Institute Institute of Infectious ,  Osaka University

Inventor： Ryosuke Suzuki ,  Maml Matsuda ,  Masamichi Muramatsu ,  Kyoko Saito ,  Masayoshi Fukasawa ,  Kentaro Hanada ,  Atsushi Yamanaka ,  Kazuo Miyazaki ,  Misuzu Yamada ,  Jun Shimizu

IPC: G01N33/569 ,  C12N7/00

Abstract: The present invention aims to provide a method for testing the function of antibodies that uses safe antigens and gives results more quickly. The present invention relates to a method for determining antibody-dependent enhancement ability of antibodies, including contacting, in the presence of a test antibody, Fcγ receptor-expressing cell with single round infectious virus particles containing a gene with a region encoding a labeled protein and a region encoding non-structural (NS) proteins 1 to 5 of the yellow fever virus genome, a capsid protein of a virus, and an outer shell protein (Envelope) of a virus, wherein when the measured label is greater than that of a negative control cell, the test antibody is determined to have an antibody-dependent enhancement ability, and the like.

公开(公告)号：US20250072744A1

公开(公告)日：2025-03-06

申请号：US18820069

申请日：2024-08-29

Applicant: OSAKA UNIVERSITY ,  TOPCON CORPORATION

Inventor： Takashi FUJIKADO ,  Yoko TATARA ,  Takafumi YUKIMORI ,  Makoto SAIKA ,  Ryoka NORO

IPC: A61B3/00 ,  A61B3/06 ,  A61B3/08 ,  A61B3/14

Abstract: An ophthalmic examination apparatus includes a visual target projection system that includes a visual target presentation portion that presents a fixed visual target to left and right subject eyes, an objective measurement optical system that objectively measures eye characteristics of the left and right subject eyes, and a controller that controls each portion of the apparatus, wherein the controller measures the eye characteristics of the left and right subject eyes with the objective measurement optical system and acquires an objective refraction value as objective measurement information when fusion is attempted with left and right subject eyes with respect to a change in the convergence distance.

公开(公告)号：US12235240B2

公开(公告)日：2025-02-25

申请号：US18009113

申请日：2021-05-25

Applicant: OSAKA UNIVERSITY

Inventor： Daichi Chiba

IPC: G01N27/82 ,  G01R33/00 ,  G01R33/07

Abstract: A magnetic body inspection method and magnetic body inspection apparatus (1) that has a magnet (10) and a magnetic sensor (20) that outputs electric signals. At least two electric signals are obtained by the magnetic sensor (20). A magnetic body present inside a nonmagnetic body can be detected non-destructively, by outputting the difference between the two obtained electric signals.

公开(公告)号：US20250057410A1

公开(公告)日：2025-02-20

申请号：US18804483

申请日：2024-08-14

Applicant: OSAKA UNIVERSITY ,  TOPCON CORPORATION

Inventor： Takashi FUJIKADO ,  Yoko TATARA ,  Takafumi YUKIMORI ,  Makoto SAIKA ,  Ryoka NORO ,  Manabu SAKAIHARA

IPC: A61B3/00 ,  A61B3/103

Abstract: An ophthalmologic apparatus includes a visual target presenting portion that presents fixation targets to subject eyes; an objective measurement optical system that objectively measures eye characteristics of the subject eyes; and a controller. Each of the fixation targets includes fusion targets depicted in a manner that allows binocular fusion while the subject eyes respectively view the fixation targets. The visual target presenting portion presents the fixation targets while changing an examination distance from the subject eyes to the fixation target when an anisometropia is induced. In the anisometropia, one subject eye is in a fully corrected condition and the other subject eye is corrected by a predetermined degree from the fully corrected condition. The controller controls the objective measurement optical system to measure the eye characteristics while the subject eyes binocularly view the fixation targets and acquire refractive values of the subject eyes as objective measurement information.

公开(公告)号：US20250052937A1

公开(公告)日：2025-02-13

申请号：US18795401

申请日：2024-08-06

Applicant: Japan Display Inc. ,  OSAKA UNIVERSITY

Inventor： Koichi IGETA ,  Junji KOBASHI ,  Yasushi TOMIOKA ,  Shinichiro OKA ,  Hiroyuki YOSHIDA

IPC: G02B5/30 ,  C09K19/30 ,  C09K19/36 ,  C09K19/50

Abstract: According to one embodiment, a liquid crystal optical element includes a transparent substrate, and a liquid crystal layer which faces the transparent substrate and has a cholesteric liquid crystal and an additive exhibiting liquid crystallinity. Refractive anisotropy of the additive is less than refractive anisotropy of the liquid crystal layer.