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公开(公告)号：US20100035900A1
公开(公告)日：2010-02-11
申请号：US12580725
申请日：2009-10-16
Applicant: Martin HENDRIX , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
Inventor： Martin HENDRIX , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC: A61K31/519 , C07D487/04 , A61P25/28
CPC classification number: C07D487/04 , A61K31/519
Abstract: The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
Abstract translation: 本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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12.发明申请6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS 审中-公开6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES作为PDE9A抑制剂公开(公告)号：US20090111838A1
公开(公告)日：2009-04-30
申请号：US12339393
申请日：2008-12-19
Applicant: Martin HENDRIX , Lars BARFACKER , Bettina BEYREUTHER , Ulrich EBERT , Christina ERB , Frank-Thorsten HAFNER , Heike HECKROTH , Yan-Hong LIU , Dagmar KARTHAUS , Adrian TERSTEEGEN , Franz-Josef VAN DER STAAY , Marja VAN KAMPEN
Inventor： Martin HENDRIX , Lars BARFACKER , Bettina BEYREUTHER , Ulrich EBERT , Christina ERB , Frank-Thorsten HAFNER , Heike HECKROTH , Yan-Hong LIU , Dagmar KARTHAUS , Adrian TERSTEEGEN , Franz-Josef VAN DER STAAY , Marja VAN KAMPEN
IPC: A61K31/513 , C07D239/36 , A61P25/00
CPC classification number: C07D239/42 , C07D401/12 , C07D409/12
Abstract: The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.
Abstract translation: 本发明涉及式（I）的新型6-芳基氨基-5-氰基-4-嘧啶酮的制备方法及其用于制备用于提高记忆力的意识，浓度，学习能力和/或保持性的药物的用途 。 所述化合物（I）显示作为PDE9抑制剂的活性。
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公开(公告)号：US08664246B2
公开(公告)日：2014-03-04
申请号：US13056676
申请日：2009-07-21
Applicant: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
Inventor： Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
IPC: A61K31/4545 , C07D401/12
CPC classification number: C07D401/14 , C07D401/12
Abstract: The invention relates to substituted pyridines and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of haematological disorders, preferably of leukopenia and neutropenia.
Abstract translation: 本发明涉及取代的吡啶及其制备方法及其制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性白细胞减少症的药物的用途。
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公开(公告)号：US08524722B2
公开(公告)日：2013-09-03
申请号：US12678288
申请日：2008-09-02
Applicant: Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
Inventor： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
IPC: A01N43/54 , A01N43/40 , A61K31/505 , A61K31/445 , C07D239/00 , C07D471/00 , C07D491/00 , C07D401/00 , C07D405/00 , C07D409/00
CPC classification number: C07D495/14 , C07D491/147 , C07D519/00
Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
Abstract translation: 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US08431573B2
公开(公告)日：2013-04-30
申请号：US13099064
申请日：2011-05-02
Applicant: Martin Hendrix , Lars Bärfacker , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen
Inventor： Martin Hendrix , Lars Bärfacker , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen
IPC: C07D487/04 , A61K31/519
CPC classification number: C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D491/10
Abstract: The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
Abstract translation: 本发明涉及新颖的氰基嘧啶酮，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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Patent Agency Ranking
![6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory](/abs-image/US/2011/10/25/US08044060B2/abs.jpg.150x150.jpg)
16.发明授权6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory 有权6-环基甲基 - 和6-烷基甲基吡唑并[3,4-D]嘧啶，其制备方法及其用于治疗感知，浓度学习和/或记忆损伤的方法公开(公告)号：US08044060B2
公开(公告)日：2011-10-25
申请号：US10556224
申请日：2004-04-28
Applicant: Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
Inventor： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC: C07D487/04 , A61K31/519 , A61P25/28 , A61P25/16 , A61P25/18
CPC classification number: C07D487/04 , A61K31/519
Abstract: Described are 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolo[3,4-d]pyrimidines of the formula (I): as defined herein, processes for their preparation and their use for producing medicaments for treating impairment of perception, concentration, learning and/or memory.
Abstract translation: 描述了式（I）的6-环甲基 - 和6-烷基甲基取代的吡唑并[3,4-d]嘧啶：如本文所定义，其制备方法及其用于制备用于治疗感知，浓度， 学习和/或记忆。
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公开(公告)号：US20110190316A1
公开(公告)日：2011-08-04
申请号：US13056676
申请日：2009-07-21
Applicant: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
Inventor： Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
IPC: A61K31/496 , C07D401/14 , A61K31/4545 , C12N5/0789 , A61P7/00
CPC classification number: C07D401/14 , C07D401/12
Abstract: The invention relates to substituted pyridines and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of haematological disorders, preferably of leukopenia and neutropenia.
Abstract translation: 本发明涉及取代的吡啶及其制备方法及其制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性白细胞减少症的药物的用途。
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![6-arylmethylprazolo[3,4-d]pyrimidines](/abs-image/US/2009/11/10/US07615558B2/abs.jpg.150x150.jpg)
公开(公告)号：US07615558B2
公开(公告)日：2009-11-10
申请号：US10556437
申请日：2004-04-27
Applicant: Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
Inventor： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC: C07D487/04 , A61K31/519 , A61P25/28
CPC classification number: C07D487/04 , A61K31/519
Abstract: Described are 6-arylmethylpyrazolo[3,4-d]pyrimidines of the following formula: processes for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
Abstract translation: 描述了下式的6-芳基甲基吡唑并[3,4-d]嘧啶：其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US07488733B2
公开(公告)日：2009-02-10
申请号：US10559954
申请日：2004-06-16
Applicant: Martin Hendrix , Lars Bärfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
Inventor： Martin Hendrix , Lars Bärfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC: C07D239/42 , C07D401/12 , A61K31/505
CPC classification number: C07D239/42 , C07D401/12 , C07D409/12
Abstract: The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.
Abstract translation: 本发明涉及式（I）的新型6-芳基氨基-5-氰基-4-嘧啶酮的制备方法及其用于制备用于提高记忆力的意识，浓度，学习能力和/或保持性的药物的用途 。 所述化合物（I）显示作为PDE9抑制剂的活性。
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公开(公告)号：US20070105881A1
公开(公告)日：2007-05-10
申请号：US10559954
申请日：2004-06-16
Applicant: Martin Hendrix , Lars Barfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
Inventor： Martin Hendrix , Lars Barfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC: A61K31/513 , C07D239/14
CPC classification number: C07D239/42 , C07D401/12 , C07D409/12
Abstract: The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.
Abstract translation: 本发明涉及式（I）的新型6-芳基氨基-5-氰基-4-嘧啶酮的制备方法及其用于制备用于提高记忆力的意识，浓度，学习能力和/或保持性的药物的用途 。 所述化合物（I）显示作为PDE9抑制剂的活性。
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