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公开(公告)号：US20080149226A1
公开(公告)日：2008-06-26
申请号：US11645443
申请日：2006-12-26
IPC分类号： C23C8/00
摘要： A method of controlling an oxygen-free heat treating process in an atmospheric pressure furnace is disclosed. The present method employs an oxygen-free gas atmosphere including hydrogen gas in concentrations between about 1.0 percent to 10.0 percent, a hydrocarbon gas, such as propylene, in concentrations of between about 0.1 percent and 10.0 percent that varies as a function of time, with the balance of the gas atmosphere being nitrogen. The presently disclosed oxygen-free carburization process uses a precisely controlled gas atmosphere to minimize inter-granular oxidation, eliminate the formation of soot and cementite, and avoid hydrogen embrittlement.
摘要翻译： 公开了一种在大气压力炉中控制无氧热处理工艺的方法。 本发明方法采用无氧气体气氛，其中浓度为约1.0％至10.0％之间的氢气，烃气体（例如丙烯）的浓度为约0.1％至10.0％，其浓度随时间而变化， 天然气气氛的平衡是氮气。 目前公开的无氧渗碳方法使用精确控制的气体气氛来最小化颗粒间氧化，消除烟灰和渗碳体的形成，并避免氢脆化。
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公开(公告)号：US20080141715A1
公开(公告)日：2008-06-19
申请号：US11639569
申请日：2006-12-15
IPC分类号： F25J3/00
CPC分类号： A61L2/022 , F17C2221/014 , F17C2260/044
摘要： A system and method for sterilizing a cryogen is provided. In the disclosed embodiment a liquid cryogen is first vaporized and subsequently compressed prior to undergoing sterilization using biological filters. The compressed, sterilized cryogen vapor is then pre-cooled, preferably with the cryogen being vaporized, to produce a partially condensed, cool, sterile cryogen stream and then further condensed using the liquid cryogen to produce a sterilized liquid cryogen.
摘要翻译： 提供了一种用于对冷冻剂灭菌的系统和方法。 在所公开的实施方案中，液体冷冻剂首先在使用生物过滤器进行灭菌之前蒸发并随后压缩。 然后将经压缩的灭菌的冷冻剂蒸气预先冷却，优选在冷冻剂被蒸发的情况下，产生部分冷凝的，冷却的无菌制冷剂流，然后使用液体冷冻剂进一步冷凝以产生无菌液体冷冻剂。
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公开(公告)号：US06592829B2
公开(公告)日：2003-07-15
申请号：US09774031
申请日：2001-01-31
申请人： Shrikar Chakravarti , Amitabh Gupta
发明人： Shrikar Chakravarti , Amitabh Gupta
IPC分类号： B01D5360
CPC分类号： B01D53/62 , B01D53/1418 , B01D53/1475 , B01D2257/504 , C01B32/50 , Y02C10/04 , Y02C10/06 , Y02P20/152
摘要： A system for recovering absorbate such as carbon dioxide from an oxygen containing mixture wherein carbon dioxide is concentrated in an alkanolamine containing absorption fluid, oxygen is separated from the absorption fluid, the resulting fluid is heated, and carbon dioxide is steam stripped from the absorption fluid and recovered.
摘要翻译： 从含氧混合物中回收吸收剂如二氧化碳的系统，其中二氧化碳浓缩在含有链烷醇胺的吸收流体中，氧从吸收流体中分离出来，所得流体被加热，二氧化碳从吸收流体中蒸汽汽提 并恢复。
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14.发明申请BIOREACTOR WITH UPWARD FLOWING IMPELLER SYSTEM FOR USE IN A MAMMALIAN CELL CULTURE PROCESS 有权具有向上流动的叶轮系统的生物反应器在马马里细胞培养过程中使用公开(公告)号：US20130189767A1
公开(公告)日：2013-07-25
申请号：US13559957
申请日：2012-07-27
申请人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
IPC分类号： C12M1/00
CPC分类号： C12M27/20 , C12M27/02 , C12M27/24 , C12M29/06 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48 , C12N1/38
摘要： A bioreactor with an upward flowing impeller system for controlling a mammalian cell culture process is provided. The disclosed system enables control of the cell culture process by controlling the level of dissolved carbon dioxide in the cell culture media and prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide via surface gas exchange with little or no damage to the mammalian cells. The use of an upward flow impeller combined with vertical baffles converts the swirling motions of the cell culture media into a largely vertical flow and promotes the removal of dissolved carbon dioxide via surface gas exchange with a sweep gas flowing over the top surface of the cell culture media within the bioreactor vessel.
摘要翻译： 提供了一种具有向上流动的叶轮系统用于控制哺乳动物细胞培养过程的生物反应器。 所公开的系统能够通过控制细胞培养基中溶解的二氧化碳的水平来控制细胞培养过程，并且通过经由表面气体交换增强汽提二氧化碳来实现渗透压浓度的增加，对哺乳动物几乎没有或没有损伤 细胞。 使用与垂直挡板结合的向上流动叶轮将细胞培养基的旋转运动转化为大体垂直的流动，并通过与流过细胞培养物顶表面的吹扫气体的表面气体交换促进去除溶解的二氧化碳 生物反应器容器内的介质。
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15.发明申请公开(公告)号：US20100035343A1
公开(公告)日：2010-02-11
申请号：US12536559
申请日：2009-08-06
申请人： Alan T.Y. Cheng , Ying Zhou , Balazs Hunek , Amitabh Gupta , Nigel Grinter
发明人： Alan T.Y. Cheng , Ying Zhou , Balazs Hunek , Amitabh Gupta , Nigel Grinter
摘要： A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow.
摘要翻译： 提供了一种用于控制哺乳动物细胞培养方法的系统和方法。 细胞培养过程的这种控制涉及控制细胞培养基中溶解的二氧化碳的水平，并且通过增强对二氧化碳的去除而对哺乳动物细胞几乎没有或没有损伤来实现所产生的渗透压浓度增加的能力。 所公开的溶解二氧化碳汽提方法和系统包括通过使用与垂直挡板结合的向上流动叶轮将生物反应器容器内的表面气体交换机制改进为将液体的旋转运动转化成大体垂直的流动。
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公开(公告)号：US20080149227A1
公开(公告)日：2008-06-26
申请号：US11645447
申请日：2006-12-26
IPC分类号： C23C8/00
CPC分类号： C23C8/20
摘要： A method of oxygen-free heat treatment of a steel part in an atmospheric pressure furnace is disclosed. The present method employs an oxygen-free controlled gas atmosphere including hydrogen gas in concentrations between about 1.0 percent to 10.0 percent, a hydrocarbon gas, such as propylene, in concentrations of between about 0.1 percent and 10.0 percent that varies as a function of time, with the balance of the gas atmosphere being nitrogen. The presently disclosed oxygen-free heat treatment process, preferably a carburization process, uses a precisely controlled atmosphere to minimize inter-granular oxidation, eliminate the formation of soot and cementite or other metallic carbides, and avoid hydrogen embrittlement.
摘要翻译： 公开了一种在大气压力炉中对钢部件进行无氧热处理的方法。 本方法采用无氧的可控气体气氛，包括浓度在约1.0％至10.0％之间的氢气，烃气体（如丙烯）的浓度在约0.1％至10.0％之间，其浓度随时间而变化， 气体气氛的平衡是氮气。 目前公开的无氧热处理方法，优选渗碳方法，使用精确控制的气氛以使颗粒间氧化最小化，消除烟灰和渗碳体或其它金属碳化物的形成，并避免氢脆化。
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公开(公告)号：US20080149225A1
公开(公告)日：2008-06-26
申请号：US11959825
申请日：2008-02-14
IPC分类号： C23C8/20
摘要： A method of oxygen-free heat treatment of a steel part in an atmospheric pressure furnace is disclosed. The present batch treatment process employs an oxygen-free controlled gas atmosphere including hydrogen gas in concentrations between about 1.0 percent to 10.0 percent, a hydrocarbon gas, such as propylene, in concentrations of between about 0.1 percent and 10.0 percent that varies as a function of time, with the balance of the gas atmosphere being nitrogen. The present continuous furnace treatment process employs a plurality of zones with each zone including an oxygen-free controlled gas atmosphere including hydrogen gas in concentrations between about 1.0 percent to 10.0 percent that varies across the different zones, a hydrocarbon gas, such as propylene, in concentrations of between about 0.1 percent and 10.0 percent that varies across the different zones, with the balance of the gas atmosphere within each zone being nitrogen. The presently disclosed oxygen-free heat treatment processes, preferably carburization processes, use a precisely controlled atmosphere to minimize inter-granular oxidation, eliminate the formation of soot and cementite or other metallic carbides, and avoid hydrogen embrittlement.
摘要翻译： 公开了一种在大气压力炉中对钢部件进行无氧热处理的方法。 本批次处理方法采用无氧可控气体气氛，其中浓度为约1.0％至10.0％之间的氢气，烃类气体（如丙烯）的浓度为约0.1％至10.0％，其浓度为 时间，天然气气氛的平衡是氮气。 本连续炉处理方法采用多个区域，每个区域包括无氧的可控气体气氛，包括在不同区域之间变化的浓度在约1.0％至10.0％之间的氢气，烃气体如丙烯， 在不同区域之间变化的约0.1％和10.0％之间的浓度，每个区域内的气体气氛的平衡是氮气。 目前公开的无氧热处理方法，优选渗碳方法，使用精确控制的气氛以使颗粒间氧化最小化，消除烟灰和渗碳体或其它金属碳化物的形成，并避免氢脆化。
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公开(公告)号：US06174506B1
公开(公告)日：2001-01-16
申请号：US09329279
申请日：1999-06-10
申请人： Shrikar Chakravarti , Amitabh Gupta
发明人： Shrikar Chakravarti , Amitabh Gupta
IPC分类号： B01D5362
CPC分类号： B01D53/1418 , C01B32/50 , Y02C10/04 , Y02C10/06 , Y02P20/152
摘要： A process for recovering carbon dioxide from a gas containing both carbon dioxide and oxygen wherein a carbon dioxide and oxygen containing gas is first contacted with an alkanolamine solution to produce an alkanolamine loaded with carbon dioxide and oxygen, the oxygen is separated from the absorption solution, such as by stripping with a scavenging gas, such as the carbon dioxide containing fluid obtained from the separation of carbon dioxide from the alkanolamine solution or nitrogen, prior to any heating of the absorption solution, and carbon dioxide is steam stripped from the absorption solution and recovered. By stripping the oxygen out of the alkanolamine solution, oxidative degradation of the alkanolamine can be reduced.
摘要翻译： 一种从含有二氧化碳和氧气的二氧化碳中回收二氧化碳的方法，其中首先使二氧化碳和含氧气体与链烷醇胺溶液接触以产生负载有二氧化碳和氧气的链烷醇胺，将氧与吸收溶液分离， 例如在吸收溶液的任何加热之前通过用清除气体例如含有二氧化碳的流体从链烷醇胺溶液或氮气中分离出二氧化碳的流体汽提，并且二氧化碳是从吸收溶液中汽提的， 恢复。 通过从烷醇胺溶液中除去氧气，可以降低链烷醇胺的氧化降解。
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19.发明授权Bioreactor with upward flowing impeller system for use in a mammalian cell culture process 有权具有向上流动的叶轮系统的生物反应器用于哺乳动物细胞培养过程公开(公告)号：US09181521B2
公开(公告)日：2015-11-10
申请号：US13559957
申请日：2012-07-27
申请人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
CPC分类号： C12M27/20 , C12M27/02 , C12M27/24 , C12M29/06 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48 , C12N1/38
摘要： A bioreactor with an upward flowing impeller system for controlling a mammalian cell culture process is provided. The disclosed system enables control of the cell culture process by controlling the level of dissolved carbon dioxide in the cell culture media and prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide via surface gas exchange with little or no damage to the mammalian cells. The use of an upward flow impeller combined with vertical baffles converts the swirling motions of the cell culture media into a largely vertical flow and promotes the removal of dissolved carbon dioxide via surface gas exchange with a sweep gas flowing over the top surface of the cell culture media within the bioreactor vessel.
摘要翻译： 提供了一种具有向上流动的叶轮系统用于控制哺乳动物细胞培养过程的生物反应器。 所公开的系统能够通过控制细胞培养基中溶解的二氧化碳的水平来控制细胞培养过程，并且通过经由表面气体交换增强汽提二氧化碳来实现渗透压浓度的增加，对哺乳动物几乎没有或没有损伤 细胞。 使用与垂直挡板结合的向上流动叶轮将细胞培养基的旋转运动转化为大体垂直的流动，并通过与流过细胞培养物顶表面的吹扫气体的表面气体交换促进去除溶解的二氧化碳 生物反应器容器内的介质。
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公开(公告)号：US06669916B2
公开(公告)日：2003-12-30
申请号：US09780539
申请日：2001-02-12
申请人： Carl Joseph Heim , Amitabh Gupta
发明人： Carl Joseph Heim , Amitabh Gupta
IPC分类号： B01D5372
CPC分类号： B01D53/04 , B01D53/864 , B01D2253/102 , B01D2256/22 , B01D2257/702 , B01D2259/402 , Y02C10/08
摘要： Disclosed are a carbon dioxide purification process and apparatus including (i) an adsorbing step for removing a predetermined amount of hydrocarbons from a carbon dioxide feed gas to reduce the caloric value of the feed stream, and (ii) a catalytic oxidation step located downstream of the adsorbing step for removing residual hydrocarbons from the feed gas by catalytic oxidation.
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