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    BETA-LACTAMASE VARIANTS
    12.
    发明申请
    BETA-LACTAMASE VARIANTS 审中-公开

    公开(公告)号：US20200318094A1

    公开(公告)日：2020-10-08

    申请号：US16757968

    申请日：2018-10-24

    Applicant: Da Volterra ,  Bioaster

    Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

    IPC: C12N9/86 ,  A61K38/50 ,  A61K31/407 ,  A61K31/496 ,  A61K31/546

    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

    Device and method for acquiring a particle present in a sample
    17.
    发明授权
    Device and method for acquiring a particle present in a sample 有权

    公开(公告)号：US10831156B2

    公开(公告)日：2020-11-10

    申请号：US16095537

    申请日：2017-04-27

    Applicant: BIOMERIEUX ,  BIOASTER

    Inventor： Alice Douet ,  Quentin Josso

    IPC: G03H1/08 ,  G03H1/04 ,  G01N15/14 ,  G06T7/55 ,  C12Q1/20 ,  G01N15/10 ,  G01N21/45 ,  G06T7/00

    Abstract: A device for acquisition of particles present in a sample includes a spatially coherent light source, an optical system, and an image sensor placed in the focal plane of the optical system. The image sensor is configured to capture an intensity image. A computational unit of the device is configured to construct a series of electromagnetic propagation matrices obtained for a plurality of defocusing offsets relative to a plane of focus of the optics. The computational unit is also configured to determine a first average focused electromagnetic matrix for the particles from the series of electromagnetic matrices, identifying at least one of the particles in the first electromagnetic matrix and storing the coordinates of said particle, and determining a second electromagnetic matrix at a distance of focus on a particle identified from the components of the series of electromagnetic matrices having the stored coordinates.

    BETA-LACTAMASE VARIANTS
    18.
    发明申请
    BETA-LACTAMASE VARIANTS 审中-公开

    公开(公告)号：US20190062719A1

    公开(公告)日：2019-02-28

    申请号：US16078040

    申请日：2017-02-22

    Applicant: DA VOLTERRA ,  BIOASTER

    Inventor： Jean DE GUNZBURG ,  Jean-Denis DOCQUIER

    IPC: C12N9/86 ,  A61K45/06 ,  A61K38/50

    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

    DIGITAL HOLOGRAPHIC IMAGING TECHNIQUE WITH TWIN IMAGE ELIMINATION
    20.
    发明公开
    DIGITAL HOLOGRAPHIC IMAGING TECHNIQUE WITH TWIN IMAGE ELIMINATION 审中-公开

    公开(公告)号：US20230408977A1

    公开(公告)日：2023-12-21

    申请号：US18031663

    申请日：2021-10-19

    Applicant: BIOMERIEUX ,  BIOASTER

    Inventor： Zohreh SEDAGHAT ,  Quentin JOSSO ,  Fabian ROL

    IPC: G03H1/00

    CPC classification number: G03H1/0005 ,  G03H2001/0816

    Abstract: A digital holographic imaging technique, includes iterative steps of: a) through back-propagation to the object coordinate of a hologram field comprising a spatial distribution of amplitude corresponding to the spatial distribution of intensity of the hologram and a spatial distribution of phase, determining an object field involving a spatial distribution of absorption and of phase shift of the imaged object, b) thresholding the values of the spatial distribution of absorption and of phase shift by decreasing the values to below a respective threshold, the thresholds decreasing in each iteration, c) through repropagation of the object field to the hologram coordinate, determining a modified hologram field comprising a modified spatial distribution of amplitude and a modified spatial distribution of phase, d) replacing the spatial distribution of phase of the hologram field with the modified spatial distribution of phase, the spatial distribution of phase shift and of absorption of the imaged object being those of the object field of the last iteration.

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