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    Method and equipment for fiber optic high-resolution, in particular confocal, fluorescence imaging
    14.
    发明授权
    Method and equipment for fiber optic high-resolution, in particular confocal, fluorescence imaging 有权
    光纤高分辨率的方法和设备，特别是共聚焦，荧光成像

    公开(公告)号：US07447539B2

    公开(公告)日：2008-11-04

    申请号：US10521607

    申请日：2003-07-11

    Applicant: Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

    Inventor： Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

    IPC: A61B1/06

    CPC classification number: H04N1/0281 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0084 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/0084 ,  G02B23/26 ,  G02B26/101

    Abstract: A method using an image guide having several thousands of optical fibers, an excitation signal emitted by a source, deflected and injected by turns into the optical fibers, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method focuses the beam in the fiber output to excite a subsurface plane to produce a confocal image. The production of a divergent beam in the fiber output can excite a micro-volume of the tissue from the surface. The method deflects the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one-by-one.

    Abstract translation: 使用具有数千光纤的图像引导器的方法，由源发射的激发信号，被偏转并被轮流注入光纤中，光纤输出中的组织的每个激发点发射，以返回由 光纤，然后检测并数字化以形成图像元素。 该方法将光束聚焦在光纤输出中以激发地下平面以产生共焦图像。 纤维输出中的发散光束的产生可以从表面激发组织的微量。 该方法使得激励信号以对应于每秒钟拍摄的图像的速度相应的速度偏转，足以实时使用，并且检测在对应于最小频率的检测频率处的荧光信号，以对纤维进行逐一采样。

    Multimarking Fibre-Type Fluorescence Microscopic Imaging Method And System
    15.
    发明申请
    Multimarking Fibre-Type Fluorescence Microscopic Imaging Method And System 有权
    多标记纤维型荧光显微镜成像方法与系统

    公开(公告)号：US20080029711A1

    公开(公告)日：2008-02-07

    申请号：US11629213

    申请日：2005-06-09

    Applicant: Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

    Inventor： Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

    IPC: G01N21/64

    CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N2021/6417 ,  G01N2021/6423

    Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophors contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophors. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

    Abstract translation: 本发明涉及一种用于制备样品的荧光纤维图像的方法，其中借助于激发信号扫描样品; 检测从样品发出的荧光信号，其中激发信号和荧光信号使用相同的光路; 光路用于激发样品中包含的至少两种荧光体; 产生最终图像，包括根据至少两个荧光体着色的区域。 根据本发明的多标记使得可以同时获取两个不同波长带中的两个图像。 根据本发明的系统可以包括用于荧光信号的光谱定量的光谱仪。

    Miniaturized focusing optical head in particular for endoscope
    16.
    发明申请
    Miniaturized focusing optical head in particular for endoscope 有权
    微型聚焦光学头，特别是内窥镜

    公开(公告)号：US20050157981A1

    公开(公告)日：2005-07-21

    申请号：US10499987

    申请日：2002-12-20

    Applicant: Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

    Inventor： Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B6/32

    CPC classification number: A61B1/00188 ,  A61B2562/0242 ,  A61B2562/146

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    Abstract translation: 一种用于装备柔性光纤束的远端的光学头，设计成被推动与分析表面接触并且包括用于将激发信号聚焦到位于分析器下方特定深度处的所谓的激发焦点的光学元件 表面，并对由纤维束承载的激发焦点反向散射的信号采样。 头部包括光纤保持器管，其中插入在纤维束的远端部分的一侧和另一个光学元件上，其中光学元件包括与纤维束的端部接触的板，其中指数接近 光纤芯和聚焦光学块的输出窗口进一步提供适于提供指标适应以消除在分析表面上发生的寄生反射。

    Miniaturized optical head with high spatial resolution and high sensitivity, especially for fibred confocal fluorescence imaging
    18.
    发明授权
    Miniaturized optical head with high spatial resolution and high sensitivity, especially for fibred confocal fluorescence imaging 有权
    具有高空间分辨率和高灵敏度的小型化光学头，特别是用于纤维共聚焦荧光成像

    公开(公告)号：US08300326B2

    公开(公告)日：2012-10-30

    申请号：US12299158

    申请日：2007-04-27

    Applicant: Magalie Genet ,  Gilles Mathieu ,  Bertrand Viellerobe ,  François Doussoux ,  Nicolas Boularot ,  Nicolas Lavillonniere

    Inventor： Magalie Genet ,  Gilles Mathieu ,  Bertrand Viellerobe ,  François Doussoux ,  Nicolas Boularot ,  Nicolas Lavillonniere

    IPC: G02B9/34

    CPC classification number: A61B1/00188 ,  G02B21/0028 ,  G02B21/0072 ,  G02B23/243 ,  G02B27/0025

    Abstract: A miniaturized optical head provided to equip the distal end of a beam of flexible optical fibers scanned by a laser beam, is designed to come in contact with a sample and to excite the sample confocally. This optical head includes elements for correcting spherical aberrations and focusing members. The focusing members include: at least a first lens (L4) of high convergence associated with a spherical or hemispherical lens (L5) arranged at the distal end of the optical head, and elements for correcting the axial and lateral chromatic aberration provided with a single divergent lens (3b) whose curvature is substantially centered on the pupil of the optical fiber beam and arranged at the exact distance for this pupil for which the conditions of lateral achromatization coincide with the conditions of axial achromatization; this divergent lens being associated with a second convergent lens (L3a) in the form of a doublet (L3).

    Abstract translation: 设置用于装备由激光束扫描的柔性光纤束的远端的小型化光学头设计成与样品接触并共同激发样品。 该光学头包括用于校正球面像差和聚焦构件的元件。 聚焦构件包括：至少与布置在光学头的远端处的球形或半球形透镜（L5）相关联的高会聚的第一透镜（L4），以及用于校正轴向和横向色像差的元件，其具有单个 发散透镜（3b），其曲率基本上位于光纤束的光瞳上，并且被布置在该瞳孔的准确距离处，其侧向消色差条件与轴向消色差条件一致; 该发散透镜与双峰（L3）形式的第二会聚透镜（L3a）相关联。

    MINIATURIZED OPTICAL HEAD WITH HIGH SPATIAL RESOLUTION AND HIGH SENSITIVITY, ESPECIALLY FOR FIBRED CONFOCAL FLUORESCENCE IMAGING
    19.
    发明申请
    MINIATURIZED OPTICAL HEAD WITH HIGH SPATIAL RESOLUTION AND HIGH SENSITIVITY, ESPECIALLY FOR FIBRED CONFOCAL FLUORESCENCE IMAGING 有权
    具有高空间分辨率和高灵敏度的微型光学头，特别适用于模拟的共焦荧光成像

    公开(公告)号：US20100296178A1

    公开(公告)日：2010-11-25

    申请号：US12299158

    申请日：2007-04-27

    Applicant: Magalie Genet ,  Gilles Mathieu ,  Bertrand Viellerobe ,  Francois Doussoux ,  Nicolas Boularot ,  Nicolas Lavillonniere

    Inventor： Magalie Genet ,  Gilles Mathieu ,  Bertrand Viellerobe ,  Francois Doussoux ,  Nicolas Boularot ,  Nicolas Lavillonniere

    IPC: G02B3/00

    CPC classification number: A61B1/00188 ,  G02B21/0028 ,  G02B21/0072 ,  G02B23/243 ,  G02B27/0025

    Abstract: A miniaturized optical head provided to equip the distal end of a beam of flexible optical fibres scanned by a laser beam, is designed to come in contact with a sample and to excite the sample confocally. This optical head includes elements for correcting spherical aberrations and focusing members. The focusing members include: at least a first lens (L4) of high convergence associated with a spherical or hemispherical lens (L5) arranged at the distal end of the optical head, and elements for correcting the axial and lateral chromatic aberration provided with a single divergent lens (3b) whose curvature is substantially centered on the pupil of the optical fibre beam and arranged at the exact distance for this pupil for which the conditions of lateral achromatization coincide with the conditions of axial achromatization; this divergent lens being associated with a second convergent lens (L3a) in the form of a doublet (L3).

    Abstract translation: 设置用于装备由激光束扫描的柔性光纤束的远端的小型化光学头设计成与样品接触并共同激发样品。 该光学头包括用于校正球面像差和聚焦构件的元件。 聚焦构件包括：至少与布置在光学头的远端处的球形或半球形透镜（L5）相关联的高会聚的第一透镜（L4），以及用于校正轴向和横向色像差的元件，其具有单个 发散透镜（3b），其曲率基本上位于光纤束的光瞳上，并且被布置在该瞳孔的准确距离处，其侧向消色差条件与轴向消色差条件一致; 该发散透镜与双峰（L3）形式的第二会聚透镜（L3a）相关联。

    Miniature optical head with integrated scanning for producing a homogeneous image and confocal imaging system using said head
    20.
    发明申请
    Miniature optical head with integrated scanning for producing a homogeneous image and confocal imaging system using said head 审中-公开
    具有集成扫描的微型光学头，用于产生使用所述头部的均匀图像和共聚焦成像系统

    公开(公告)号：US20090023999A1

    公开(公告)日：2009-01-22

    申请号：US10584854

    申请日：2004-12-29

    Applicant: Gilles Mathieu ,  Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier

    Inventor： Gilles Mathieu ,  Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier

    IPC: A61B1/06

    CPC classification number: G02B21/0036 ,  A61B1/00188 ,  A61B1/05 ,  G02B7/027 ,  G02B21/0032

    Abstract: A miniature confocal optical head (4) for a confocal imaging system, in particular endoscopic, includes a point source (2a) for producing a light beam (13); a ball lens (12) arranged at the tip of the optical head, partly outside, to cause the light beam to converge in an excitation point (19) located in a subsurface field under observation (14) of a sample (15), the digital aperture of the lens and the dimension of the point source being adapted to ensure confocality of the assembly; and a scanner (10, 211, 22) for rotating the point source so that the excitation point (19) scans the field under observation. The system produces a real-time confocal image (about 10 images/sec.) of very high quality and homogeneous in the entire field (the optical aberrations are constant in the entire field due to the spherical symmetry of the ball lens), achieved through a miniature head.

    Abstract translation: 用于共焦成像系统，特别是内窥镜的微型共焦光学头（4）包括用于产生光束（13）的点光源（2a）; 布置在所述光学头部的前端的球状透镜（12），其部分地在外部，以使所述光束会聚在位于样品（15）的观察（14）的地下场的激发点（19）中，所述激光点 透镜的数字孔径和点源的尺寸适于确保组件的共焦; 以及用于旋转点源的扫描器（10,211,22），使得激发点（19）扫描观察的场。 该系统在整个场中产生非常高质量和均匀的实时共焦图像（约10个图像/秒）（由于球透镜的球形对称性，光学像差在整个场中是恒定的），通过 一个微型头。

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