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    PROANTHOCYANIDINS FOR THE TREATMENT OF AMYLOID AND ALPHA-SYNUCLEIN DISEASES
    14.
    发明申请
    PROANTHOCYANIDINS FOR THE TREATMENT OF AMYLOID AND ALPHA-SYNUCLEIN DISEASES 审中-公开
    用于治疗淀粉样变性和阿尔茨海默病的PROANTHOCYANIDINS

    公开(公告)号：US20100197778A1

    公开(公告)日：2010-08-05

    申请号：US12475097

    申请日：2009-05-29

    申请人： Alan D. Snow ,  Gerardo M. Castillo ,  Paula Choi ,  Beth Nguyen

    发明人： Alan D. Snow ,  Gerardo M. Castillo ,  Paula Choi ,  Beth Nguyen

    IPC分类号： A61K31/353 ,  A61P25/28 ,  A61P25/00 ,  A61P25/16 ,  A61P1/18 ,  A61P3/10 ,  A61P29/00

    CPC分类号： A61K31/215 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/74 ,  A61K45/06 ,  A61K2300/00

    摘要： A method of treating an amyloid disease, or a disease characterized by IAPP amyloid fibrils or islet amyloid deposits, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed procyanidins or proanthocyanidins characterized by disclosed general formulae. A pharmaceutical composition and use of the composition comprising a therapeutically effective amount of a procyanidin and a pharmaceutically acceptable excipient. The therapeutic amount of the proanthocyanidin is selected for efficacy in treating IAPP amyloid fibrils or islet amyloid deposits in a mammalian subject.

    摘要翻译： 哺乳动物受试者中治疗淀粉样蛋白病或IAPP淀粉样蛋白原纤维或胰岛淀粉样沉积物特征的疾病的方法。 该方法包括向哺乳动物施用治疗有效量的各种所​​公开的原花青素或原花青素，其特征在于所公开的通式。 药物组合物和组合物的用途，其包含治疗有效量的原花青素和药学上可接受的赋形剂。 选择原花青素的治疗量用于在哺乳动物受试者中治疗IAPP淀粉样蛋白原纤维或胰岛淀粉样蛋白沉积物的功效。

    Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
    15.
    发明申请
    Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies 有权
    取代的N-芳基苯甲酰胺和相关化合物用于治疗淀粉样蛋白病和突触核蛋白病

    公开(公告)号：US20060199838A1

    公开(公告)日：2006-09-07

    申请号：US11328748

    申请日：2006-01-09

    申请人： Alan Snow ,  Beth Nguyen ,  Thomas Lake ,  Gerardo Castillo ,  Manfred Weigele

    发明人： Alan Snow ,  Beth Nguyen ,  Thomas Lake ,  Gerardo Castillo ,  Manfred Weigele

    IPC分类号： A61K31/46 ,  C07D457/02 ,  A61K31/165

    CPC分类号： C07C311/08

    摘要： Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided.

    摘要翻译： 取代的正芳基苯甲酰胺，相关化合物及其药学上可接受的衍生物，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白疾病中的用途，包括Aβ淀粉样变性，例如在阿尔茨海默病，IAPP淀粉样变性中观察到的 提供2型糖尿病和突触核蛋白病，例如在帕金森病中观察到的，并且提供了用于这种治疗的药物的制造。

    SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES
    18.
    发明申请
    SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES 审中-公开
    取代的N-亚苄基苯甲酸和相关化合物用于治疗淀粉样变性疾病和综合征

    公开(公告)号：US20090060838A1

    公开(公告)日：2009-03-05

    申请号：US12201183

    申请日：2008-08-29

    申请人： Alan Snow ,  Manfred Weigele ,  Lesley Larsen ,  Beth Nguyen ,  Thomas Lake ,  Gerardo Castillo

    发明人： Alan Snow ,  Manfred Weigele ,  Lesley Larsen ,  Beth Nguyen ,  Thomas Lake ,  Gerardo Castillo

    IPC分类号： A61K51/04 ,  C07C233/88 ,  A61K101/02 ,  A61K31/167

    CPC分类号： C07C311/08

    摘要： Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and diagnosis of amyloid and synuclein diseases.

    摘要翻译： 取代的正芳基苯甲酰胺，相关化合物及其药学上可接受的盐，它们的合成和标记，含有它们的药物组合物及其在治疗淀粉样蛋白疾病中的用途，包括Aβ淀粉样变性，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，并且提供突触核蛋白病，例如在帕金森病中观察到的，并且提供了用于这种治疗的药物的制造。 还提供了所公开的化合物作为淀粉样蛋白和突触核蛋白疾病的体内成像和诊断的显像剂和方法的用途。