公开(公告)号：US20130180906A1

公开(公告)日：2013-07-18

申请号：US13349185

申请日：2012-01-12

Applicant: Christopher J. Ball ,  Brian Bates

Inventor： Christopher J. Ball ,  Brian Bates

IPC: B01D35/30

CPC classification number: B01D24/22 ,  B01D24/24 ,  B01D24/4631 ,  G06Q50/22 ,  H04N7/18

Abstract: A filter system for filtering a liquid containing particles including a single media retainer plate having a top and bottom surface, and defining at least one hopper-shaped compartment having a sloped wall defining a slot spanning the top and bottom surfaces is disclosed. The plate also includes at least one baffle extending from the bottom surface and filter media disposed on the top surface. During a filtering operation of the filter system, the filter media captures the particles, such as dirt, from the liquid as the liquid passes through the filter media to an underdrain system. During a backwash operation of the filter system, the baffle is adapted to direct a backwash fluid in a vertical direction through the slot so that the backwash fluid actuates the filter media to scour the top surface of the plate and prevent the build-up of biological scaling on the plate.

Abstract translation: 公开了一种过滤系统，用于过滤含有颗粒的液体，包括具有顶部和底部表面的单个介质保持板，并且限定了至少一个具有限定跨越顶部和底部表面的槽的倾斜壁的料斗形隔室。 板还包括从底表面延伸的至少一个挡板和设置在顶表面上的过滤介质。 在过滤系统的过滤操作期间，当液体通过过滤介质时，过滤介质从液体中捕获诸如污物的颗粒，从而将液体通过过滤介质。 在过滤系统的回洗操作期间，挡板适于将反冲洗流体沿垂直方向引导通过狭槽，使得反冲洗流体致动过滤介质以冲洗板的顶表面并防止生物体的积聚 在板上缩放。

公开(公告)号：US20120172654A1

公开(公告)日：2012-07-05

申请号：US12982588

申请日：2010-12-30

Applicant: Brian Bates

Inventor： Brian Bates

IPC: A61M1/12

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008 ,  A61M1/1006 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125

Abstract: A ventricular assist device includes an intravascular blood pump and a collapsible frame. The collapsible frame receives the blood pump therein and is movable between a collapsed state and an expanded state. The collapsible frame engages an interior wall of a body cavity when in the expanded state and is retrievable from the body cavity in the collapsed state.

Abstract translation: 心室辅助装置包括血管内血液泵和可折叠框架。 可折叠框架在其中接收血液泵，并且可以在折叠状态和展开状态之间移动。 当处于膨胀状态时，可折叠框架接合体腔的内壁，并且在折叠状态下可从体腔回收。

公开(公告)号：US20080039535A1

公开(公告)日：2008-02-14

申请号：US11838843

申请日：2007-08-14

Applicant: Brian Bates ,  Sheree Logue ,  Mark Pausch

Inventor： Brian Bates ,  Sheree Logue ,  Mark Pausch

IPC: A61K35/00 ,  A61P25/18 ,  G01N33/00

CPC classification number: G01N33/6896 ,  G01N2500/10 ,  G01N2800/2835 ,  G01N2800/302 ,  G01N2800/304 ,  G01N2800/305

Abstract: Methods of identifying agents for treatment of schizophrenia and related disorders.

Abstract translation: 识别治疗精神分裂症和相关疾病的药物的方法。

公开(公告)号：US20070203520A1

公开(公告)日：2007-08-30

申请号：US11654278

申请日：2007-01-16

Applicant: Dennis Griffin ,  Arne Molgaard-Nielsen ,  Anthony Ragheb ,  Raymond Leonard ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  Brian Bates ,  Thomas Osborne

Inventor： Dennis Griffin ,  Arne Molgaard-Nielsen ,  Anthony Ragheb ,  Raymond Leonard ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  Brian Bates ,  Thomas Osborne

IPC: A61M29/00

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0086 ,  A61F2250/0067

Abstract: Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.

Abstract translation: 包括具有远端（18）的多个支柱（14）的血管内过滤器（10），其适于在部署之后将过滤器锚定到血管壁，例如通过具有倒钩（20），如果需要，该过滤器适于被检索。 支架远端（18）涂覆有抗增殖剂（40），其抑制过滤器周围的组织的向内生长，从而允许过滤器在延长的时间段后无损伤地取出和去除，从而延长可回收的使用寿命 过滤。 可选地，过滤器的近端（22）也可以如此涂覆，或整个过滤器。

公开(公告)号：US20070082021A1

公开(公告)日：2007-04-12

申请号：US11529872

申请日：2006-09-28

Applicant: Brian Bates

Inventor： Brian Bates

IPC: A61F2/00

CPC classification number: A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12181 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61B2090/374 ,  A61B2090/3954 ,  A61L31/06 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/418 ,  A61L2300/42 ,  A61L2430/36 ,  C08L75/04

Abstract: Compositions and methods for occluding a vessel in a subject are provided in which a vaso-occlusion device includes an occluding element having a polymeric material containing a plurality of holes at least partially filled with one or more bioactive agents, the vaso-occlusion device configured to occlude a vessel in the subject.

Abstract translation: 提供了一种用于闭塞受试者中的血管的组合物和方法，其中血管闭塞装置包括具有至少部分填充有一种或多种生物活性剂的多个孔的聚合材料的阻塞元件，所述血管闭塞装置被配置为 封闭受试者的血管。

公开(公告)号：US20060052816A1

公开(公告)日：2006-03-09

申请号：US11217583

申请日：2005-08-31

Applicant: Brian Bates ,  Andrew Conder ,  Gary Butler

Inventor： Brian Bates ,  Andrew Conder ,  Gary Butler

IPC: A61M29/00

CPC classification number: A61B17/12022 ,  A61B17/12013 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/12172 ,  A61B17/12181 ,  A61B2017/00867 ,  A61B2017/00898 ,  A61B2017/12054 ,  A61B2017/12063 ,  A61B2017/12095

Abstract: A device for treating balloon-type (or berry) aneurysms is provided. The device restricts blood flow into the aneurysm with a patch that covers the neck of the aneurysm. The patch is secured within the neck of the aneurysm by an anchor member, basket, insert or other structure that engages the inner surface of the aneurysm.

Abstract translation: 提供了一种用于治疗气球型（或浆果）动脉瘤的装置。 该装置通过覆盖动脉瘤颈部的补片来限制血液流入动脉瘤。 通过与动脉瘤的内表面接合的锚固构件，篮，插入件或其他结构，将补片固定在动脉瘤的颈部内。

公开(公告)号：US09084924B2

公开(公告)日：2015-07-21

申请号：US13614346

申请日：2012-09-13

Applicant: Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

Inventor： Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

IPC: A63B69/20 ,  A63B69/00 ,  A63B69/32 ,  A63B24/00

CPC classification number: A63B69/201 ,  A63B24/0062 ,  A63B69/004 ,  A63B69/32 ,  A63B2024/0037 ,  A63B2220/53 ,  A63B2244/10 ,  A63B2244/102 ,  G09B19/0038

Abstract: A boxing or martial arts training and exercise device may include punching pads locationally displaced on a frame. Respective pads may be positioned in support on the frame for punching and kicking. Each pad can communicatively connect to one or more impact sensor. Each impact sensor can communicatively connect to a control unit. The control unit may be communicatively connected to a display. The impact sensor detects strikes to the pad. The impact sensor includes an accelerometer and a signal processor. The control unit includes an aggregator for receiving and logging strike metrics. The control unit directs sequences in the display according to a routine, and delivers indicators of strike metrics. The control unit includes a user interface for selection among sequences, as well as for selection of various menu items. A video of a human instructor or an animated avatar is viewable in a display.

Abstract translation: 拳击或武术训练和锻炼装置可以包括位于框架上位置的冲压垫。 相应的垫可以被定位在框架上用于冲压和踢脚。 每个垫可以通信地连接到一个或多个冲击传感器。 每个冲击传感器可以通信地连接到控制单元。 控制单元可以通信地连接到显示器。 撞击传感器检测到撞击垫。 冲击传感器包括加速度计和信号处理器。 控制单元包括用于接收和记录打击度量的聚合器。 控制单元根据例程指示显示中的序列，并提供罢工指标的指标。 控制单元包括用于在序列之间选择的用户界面，以及用于选择各种菜单项。 人类教练或动画头像的视频可在显示器中观看。

公开(公告)号：US08562509B2

公开(公告)日：2013-10-22

申请号：US12982588

申请日：2010-12-30

Applicant: Brian Bates

Inventor： Brian Bates

IPC: A61N1/362

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008 ,  A61M1/1006 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125

Abstract: A ventricular assist device includes an intravascular blood pump and a collapsible frame. The collapsible frame receives the blood pump therein and is movable between a collapsed state and an expanded state. The collapsible frame engages an interior wall of a body cavity when in the expanded state and is retrievable from the body cavity in the collapsed state.

Abstract translation: 心室辅助装置包括血管内血液泵和可折叠框架。 可折叠框架在其中接收血液泵，并且可以在折叠状态和展开状态之间移动。 当处于膨胀状态时，可折叠框架接合体腔的内壁，并且在折叠状态下可从体腔回收。

公开(公告)号：US20130065731A1

公开(公告)日：2013-03-14

申请号：US13614346

申请日：2012-09-13

Applicant: Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

Inventor： Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

IPC: A63B69/20 ,  A63B24/00

CPC classification number: A63B69/201 ,  A63B24/0062 ,  A63B69/004 ,  A63B69/32 ,  A63B2024/0037 ,  A63B2220/53 ,  A63B2244/10 ,  A63B2244/102 ,  G09B19/0038

Abstract: A boxing or martial arts training and exercise device may include punching pads locationally displaced on a frame. Respective pads may be positioned in support on the frame for punching and kicking Each pad can communicatively connect to one or more impact sensor. Each impact sensor can communicatively connect to a control unit. The control unit may be communicatively connected to a display. The impact sensor detects strikes to the pad. The impact sensor includes an accelerometer and a signal processor. The control unit includes an aggregator for receiving and logging strike metrics. The control unit directs sequences in the display according to a routine, and delivers indicators of strike metrics. The control unit includes a user interface for selection among sequences, as well as for selection of various menu items. A video of a human instructor or an animated avatar is viewable in a display.

Abstract translation: 拳击或武术训练和锻炼装置可以包括位于框架上位置的冲压垫。 相应的垫可以被定位在框架上以用于冲压和踢脚。每个垫可以通信地连接到一个或多个冲击传感器。 每个冲击传感器可以通信地连接到控制单元。 控制单元可以通信地连接到显示器。 撞击传感器检测到撞击垫。 撞击传感器包括加速度计和信号处理器。 控制单元包括用于接收和记录打击度量的聚合器。 控制单元根据例程指示显示中的序列，并提供罢工指标的指标。 控制单元包括用于在序列之间选择的用户界面，以及用于选择各种菜单项。 人类教练或动画头像的视频可在显示器中观看。

公开(公告)号：US20080027001A1

公开(公告)日：2008-01-31

申请号：US11774940

申请日：2007-07-09

Applicant: Andrew Wood ,  Alan Katz ,  Ying Gao ,  Brian Bates ,  Patrick Doherty ,  Gareth Williams

Inventor： Andrew Wood ,  Alan Katz ,  Ying Gao ,  Brian Bates ,  Patrick Doherty ,  Gareth Williams

IPC: A61K38/00 ,  C07D211/06 ,  C07D211/72 ,  C07D215/00 ,  C07D277/62 ,  C07D401/00 ,  C07K14/00 ,  C07K16/18 ,  C07K7/00 ,  C12N5/06 ,  C40B30/04 ,  G01N33/566

CPC classification number: C07K14/705 ,  A61K38/00 ,  G01N33/6872 ,  G01N2500/04

Abstract: The present invention provides novel isolated and purified polynucleotides and polypeptides related to functional motifs of the Nogo receptor 1 (NgR1) (e.g., the binding pocket on the side surface of NgR1, functional motifs comprising the amino acid sequence of FRG, etc.) and use of peptides mimicking these functional motifs as antagonists to NgR1 ligands, e.g., myelin-associated glycoprotein, oligodendrocyte myelin glycoprotein, Nogo-A, Nogo-66, GT1b, an antibody to Nogo receptor, an antibody to GT1b, an antibody to p75 neurotrophin receptor, and an antibody to Lingo-1, etc. The invention also provides antibodies to the mimetic peptide antagonists. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for treatments requiring axonal regeneration, i.e., reversal of the effects of NgR1 ligand binding to the NgR1 (i.e., producing inhibition of axonal growth). The present invention also is directed to novel methods for treating disorders arising from inhibition of axonal growth mediated by the binding of NgR1 ligands to the NgR1. Further, the invention is directed to methods of treating a subject with a neurodegenerative disorder, including, but not limited to, Parkinson's disease, Alzheimer's disease, progressive supranuclear palsy, multiple sclerosis, multiple system atrophy, corticobasal degeneration, Huntington's disease, dementia with Lewy bodies, spinocerebellar ataxia, stroke, spinal cord trauma, traumatic brain injury, multiinfarct dementia, epilepsy, and senile dementia, comprising, e.g., antagonizing NgR1.

Abstract translation: 本发明提供了与Nogo受体1（NgR1）的功能基序相关的新型分离和纯化的多核苷酸和多肽（例如，NgR1侧表面的结合口袋，包含FRG的氨基酸序列的功能基序等）和 使用模仿这些功能基序的肽作为NgR1配体的拮抗剂，例如髓鞘相关糖蛋白，少突胶质细胞髓鞘糖蛋白，Nogo-A，Nogo-66，GT1b，Nogo受体的抗体，GT1b的抗体，p75神经营养蛋白的抗体 受体和针对Lingo-1的抗体等。本发明还提供了针对模拟肽拮抗剂的抗体。 本发明还涉及新的治疗学和治疗靶标，以及筛选和评估需要轴突再生的治疗的试验化合物的方法，即逆转NgR1配体结合NgR1的作用（即产生轴突生长的抑制）。 本发明还涉及用于治疗由NgR1配体与NgR1结合介导的轴突生长抑制引起的疾病的新方法。 此外，本发明涉及用神经退行性疾病治疗受试者的方法，包括但不限于帕金森病，阿尔茨海默病，进行性核上性麻痹，多发性硬化，多系统萎缩，皮质基底变性，亨廷顿病，路易氏痴呆 身体，脊髓小脑性共济失调，中风，脊髓创伤，创伤性脑损伤，多发性痴呆，癫痫和老年性痴呆，包括例如拮抗NgR1。