公开(公告)号：US20210024551A1

公开(公告)日：2021-01-28

申请号：US16764805

申请日：2018-11-16

Applicant: Centre national de la recherche scientifque ,  UNIVERSITE DE CAEN NORMANDIE

Inventor： Mohamad EL ROZ ,  Sami LAKHDAR ,  Igor TELEGEIEV

IPC: C07F7/18 ,  C08F2/50 ,  C08F222/10 ,  C08F216/16

Abstract: The present invention relates to a compound of formula (I) below: in which:
R1 represents, in particular, an alkylene group comprising from 1 to 6 carbon atoms;
R2 and R3 are, in particular, H;
n is 0, 1, 2 or 3; and R4 is chosen from the group consisting of: NO2, ORa, SRa and NRaRb, wherein Ra and Rb are as defined above;
R5 and R6, identical or different, represent an alkyl or alkoxy group comprising from 1 to 6 carbon atoms; and
R7, R8 and R9, identical or different, represent an alkyl group comprising from 2 to 6 carbon atoms.

公开(公告)号：US20190284516A1

公开(公告)日：2019-09-19

申请号：US16335390

申请日：2017-09-19

Applicant: Inria Institut National De Recherche En Informat.. ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE ... ,  UNIVERSITÉ NICE SOPHIA ANTIPOLIS

Inventor： Olivier BERNARD ,  Hubert BONNEFOND ,  Antoine SCIANDRA ,  Éric PRUVOST ,  Ghjuvan GRIMAUD

IPC: C12M1/00 ,  C12N5/00 ,  C12M1/34

Abstract: The invention relates to a bioreactor comprising a tank (100) capable of being operated for a working period, said tank (100) being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms, a light source (200) arranged to emit incident light having a chosen incoming light intensity (Iin) in the direction of the tank, a temperature probe (400) for measuring the temperature of said culture medium in the tank, and a temperature regulator (500) capable of raising and lowering the temperature of said culture medium in the tank, and further comprising a control (700) of the temperature regulator arranged to adjust the temperature of the culture medium to a low setpoint value (VCB) during a first period, and to adjust the temperature of the culture medium to a high setpoint value (VCH) during a second period, the succession of said first and second periods making it possible to induce a cellular stress in at least some of said photosynthetic microorganisms during the working period.

公开(公告)号：US09488780B2

公开(公告)日：2016-11-08

申请号：US14383822

申请日：2013-03-05

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT ,  UNIVERSIT LILLE 1 SCIENCES ET TECHNOLOGIES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE

Inventor： Emmanuel Hugonnot ,  Arnaud Mussot ,  Yves Quiquempois ,  Geraud Bouwmans ,  Laurent Bigot ,  Constance Valentin

IPC: G02B6/032 ,  G02B6/14 ,  G02B6/036 ,  B23K26/073 ,  B23K26/20 ,  G02B27/09 ,  H01S3/067

CPC classification number: G02B6/14 ,  B23K26/064 ,  B23K26/073 ,  B23K26/0734 ,  B23K26/21 ,  G02B6/03611 ,  G02B6/03622 ,  G02B27/09 ,  H01S3/06741 ,  H01S3/06745

Abstract: A device for converting transverse spatial profile of intensity of a light beam, using a microstructured optical fiber. Transverse dimensions of the fiber vary longitudinally and both its ends have opto-geometrical parameters such that at the wavelength of the beam the fiber has a fundamental mode having two different profile shapes at its two ends. Thus by introducing the beam with one of the profiles through one of the two ends, the beam emerges through the other end with the other profile, whose shape is different from that of the profile of the introduced beam.

Abstract translation: 使用微结构光纤转换光束强度的横向空间分布的装置。 纤维的横向尺寸纵向变化，并且其端部都具有光学几何参数，使得在光束的波长处，光纤具有在其两端具有两个不同轮廓形状的基本模式。 因此，通过将光束中的一个通过将两个端部中的一个引入到光束中，光束通过另一端与另一个轮廓一起出射，另一个轮廓的形状与引入的光束的轮廓的形状不同。

公开(公告)号：US09187395B2

公开(公告)日：2015-11-17

申请号：US14437707

申请日：2013-10-29

Applicant: Adisseo France S.A.S. ,  Centre National de la Recherche Scientifque ,  Universite Claude Bernard

Inventor： Raja Znaiguia ,  Jean-Marc Millet ,  Stéphane Loridant ,  Patrick Rey

IPC: C07C45/52

CPC classification number: C07C45/52 ,  C07C319/18 ,  C07C47/22 ,  C07C323/22

Abstract: The disclosure concerns a method for preparing acrolein from glycerol, according to which a dehydration of the glycerol is carried out in the presence of a catalyst MWOA, wherein MWO represents a mixture of simple oxides and/or mixed oxides of tungsten and at least one metal M selected among zirconium, silicon, titanium, aluminium and yttrium, and A represents one or several Lewis base(s), one said Lewis base being of the formula B(R1)p(R2)q(R3)r, wherein B is an element selected among C, S, P, O, N and halides, R1, R2 and R3 represent, independently of each other, H, a C1-C6 alkyl group, O, OH or OR wherein R represents a C1-C6 alkyl group, and the sum of p, q and r varies from 0 to 4.

Abstract translation: 本公开涉及从甘油制备丙烯醛的方法，根据该方法，甘油的脱水在催化剂MWOA的存在下进行，其中MWO表示钨和至少一种金属的简单氧化物和/或混合氧化物的混合物 M选自锆，硅，钛，铝和钇，A表示一个或多个路易斯碱，一个所述路易斯碱为式B（R1）p（R2）q（R3）r，其中B为 选自C，S，P，O，N和卤化物的元素，R 1，R 2和R 3彼此独立地表示H，C 1 -C 6烷基，O，OH或OR，其中R表示C 1 -C 6烷基 组，p，q和r的和从0到4变化。

公开(公告)号：US20150246095A1

公开(公告)日：2015-09-03

申请号：US14430405

申请日：2013-10-01

Applicant: INSERM (Institut National de la Santé et de la Recherche Médicale) ,  INSTITUT PASTEUR DE LILLE ,  UNIVERSITE DE LILLE I-SCIENCES ET TECHNOLOGIES ,  UNIVERSITE DU DROIT ET DE LA SANTE LILLE 2 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE (CNRS)

Inventor： Francois Trottein ,  Stoyan Ivanov ,  Josette Fontaine ,  Christelle Faveeuw

IPC: A61K38/20 ,  C12Q1/68 ,  G01N33/68 ,  A61K45/06

CPC classification number: A61K38/20 ,  A61K38/2066 ,  A61K45/06 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6869 ,  G01N2800/26 ,  G01N2800/50 ,  A61K2300/00

Abstract: The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza. In particular, the present invention relates to an interleukin 22 (IL-22) polypeptide for use in the prophylactic treatment of bacterial superinfections post-influenza in a subject in need thereof.

Abstract translation: 本发明涉及用于预防性治疗流感后细菌超感染的方法和药物组合物。 特别地，本发明涉及用于在有需要的受试者中预防性治疗流感后细菌超感染的白细胞介素22（IL-22）多肽。

公开(公告)号：US11885391B2

公开(公告)日：2024-01-30

申请号：US17428890

申请日：2020-02-11

Applicant: Thales ,  Centre national de la recherche scientifque ,  Universite De Franche-Comte

Inventor： Kevin Jaboviste ,  Gaël Chevallier ,  Emeline Sadoulet-Reboul ,  Nicolas Peyret ,  Eric Collard ,  Charles Arnould

IPC: F16F7/104 ,  B64C1/00 ,  F16M13/02

CPC classification number: F16F7/104 ,  B64C1/00 ,  F16M13/02 ,  F16F2222/08 ,  F16F2228/04

Abstract: The invention relates to a device comprising a body and a set of vibration absorbers mounted on the body, each absorber being movable relative to the body between a first position and a second position, each absorber being capable of oscillating relative to the body between its first and second positions, a first natural frequency being defined for each absorber, at least one absorber having a first natural frequency different from the first natural frequency of another absorber.
Each absorber comprises at least one deformation part capable of deforming as the vibration absorber oscillates between its first position and its second position, the deformation part having at least two faces configured to rub against each other during the deformation of the deformation part.

公开(公告)号：US20230066065A1

公开(公告)日：2023-03-02

申请号：US17797265

申请日：2021-02-04

Applicant: Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Assistance Publique-Hôpitaux de Paris (APHP) ,  Centre National de la Recherche Scientifque (CNRS) ,  Fondation Imagine ,  Université Paris Cité

Inventor： Pascale DE LONLAY-DEBENEY ,  Peter VAN ENDERT ,  Sebastian MONTEALEGRE ,  Caroline TUCHMANN-DURAND ,  Laure CACCAVELLI ,  Marine MADRANGE ,  Perrine RENARD

IPC: A61K31/4706 ,  A61P3/00

Abstract: Lipin-1 deficiency is a rare, life-threatening condition that causes severe rhabdomyolysis episodes (RM) triggered by febrile illness and effort. Now, the inventors treated 10 patients with LPIN1 mutations with hydroxychloroquine (HCQ) in an off open-label use phases 1 and 2 study, to assess safety, clinical, and biological effects of the drug. A first inclusion group of patients were treated with oral HCQ at a dose of 6.5 mg/Kg/day in one intake, not exceeding 400 mg/day. Five patients have not presented any new acute RM under treatment, except for 2 patients experimented one and two episodes of RM respectively despite HCQ in a context of gastroenteritis. Plasma levels of HCQ were in the range of 400 ng/ml except in the two patients who experimented RM, in whom the plasma HCQ levels were higher (1000 ng/ml). With a therapeutic adjustment, in order to maintain plasma levels of HCQ under 700 ng/ml, in a new group of patients, two patients did not suffer from new acute RM under treatment. HCQ had not seem to have benefit effect for one patient. Thus, the inventors describe the first human experience with HCQ for Lipin-1 disease. The results allow the inventors to propose low doses of HCQ as a long-term treatment to prevent further relapses in this severe disease.

公开(公告)号：US10734591B2

公开(公告)日：2020-08-04

申请号：US15327932

申请日：2015-07-21

Applicant: Université de Strasbourg ,  UNIVERSITE DE NANTES ,  Centre national de la recherche scientifque

Inventor： Karima Benelhadj ,  Julien Massue ,  Gilles Ulrich ,  Raymond Ziessel ,  Denis Jacquemin ,  Adèle Laurent

IPC: C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  H01L51/00 ,  H01L51/50 ,  C09K11/06 ,  C09B57/00 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

Abstract: A compound is provided which has dual emission properties and which is useful in light devices, and which has formula (I): wherein: A represents an electron-withdrawing group; D represents an electron-donating group; X is selected from the group consisting of: O, S and NR, wherein R is selected from the group consisting of: H, an alkyl group preferably comprising from 1 to 20 carbon atoms, an aryl group preferably comprising from 6 to 22 carbon atoms, and a heteroaryl group; n is an integer from 1 to 4; m is an integer from 1 to 6; and represents a condensed bicyclic aromatic radical comprising from 6 to 22 carbon atoms, and from 1 to 3 heteroatom(s) selected from the group consisting of: N, S and O; the OH group being in ortho position of the condensed bicyclic aromatic radical relative to the radical.

公开(公告)号：US20190058031A1

公开(公告)日：2019-02-21

申请号：US16080279

申请日：2017-02-23

Applicant: Centre National de la Recherche Scientifque ,  Universite Claude Bernard Lyon 1 ,  Soitec

Inventor： Christophe Figuet ,  Oleg Kononchuk ,  Kassam Alassaad ,  Gabriel Ferro ,  Véronique Souliere ,  Christelle Veytizou ,  Taguhi Yeghoyan

IPC: H01L29/06 ,  H01L21/762 ,  H01L29/16 ,  H01L21/02

Abstract: A support for a semiconductor structure includes a charge-trapping layer on a base substrate. The charge-trapping layer consists of a polycrystalline main layer and, interposed in the main layer or between the main layer and the base substrate, at least one intermediate polycrystalline layer composed of a silicon and carbon alloy or carbon. The intermediate layer has a resistivity greater than 1000 ohm·cm.

公开(公告)号：US20180360877A1

公开(公告)日：2018-12-20

申请号：US16060721

申请日：2016-12-08

Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Universite d'Aix Marseille ,  Centre National de la Recherche Scientifque (CNRS) ,  Max Delbruck Center for Molecular Medicine (MDC)

Inventor： Michael SIEWEKE ,  Kaaweh MOLAWI ,  Laufey GEIRSDOTTIR

IPC: A61K35/15 ,  A61P35/00 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  C12N5/0786

Abstract: The present invention relates to methods for expanding a population of alveolar macrophages in a long term culture. In particular, an object of the present invention relates to a method of expanding a population of alveolar macrophages in a long term culture comprising culturing the population of alveolar macrophages in a culture medium supplemented with an amount of GM-CSF.