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公开(公告)号：US20080293675A1
公开(公告)日：2008-11-27
申请号：US11971693
申请日：2008-01-09
Applicant: Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
Inventor： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
CPC classification number: C07F5/025
Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
Abstract translation: 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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公开(公告)号：US07390806B2
公开(公告)日：2008-06-24
申请号：US10867465
申请日：2004-06-14
Applicant: Ving Lee , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
Inventor： Ving Lee , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
IPC: C07D484/04 , C07D215/02 , C07D215/20 , C07D239/70 , C07D253/08 , A61K31/47 , A61P31/04 , A61P31/10
CPC classification number: C07F5/025
Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
Abstract translation: 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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公开(公告)号：US20050070503A1
公开(公告)日：2005-03-31
申请号：US10867465
申请日：2004-06-14
Applicant: Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
Inventor： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
CPC classification number: C07F5/025
Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
Abstract translation: 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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公开(公告)号：US08742106B2
公开(公告)日：2014-06-03
申请号：US13517115
申请日：2010-12-20
Applicant: Sangamesh Badiger , Dirk Behnke , Claudia Betschart , Vinod Chaudhari , Murali Chebrolu , Simona Cotesta , Samuel Hintermann , Arndt Meyer , Chetan Pandit
Inventor： Sangamesh Badiger , Dirk Behnke , Claudia Betschart , Vinod Chaudhari , Murali Chebrolu , Simona Cotesta , Samuel Hintermann , Arndt Meyer , Chetan Pandit
IPC: C07D471/04 , C07D498/04 , C07D519/00
CPC classification number: C07D471/04 , C07D498/04 , C07D519/00
Abstract: The invention relates to compound of the formula (I′) in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I'）的化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
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Patent Agency Ranking
公开(公告)号：US08614239B2
公开(公告)日：2013-12-24
申请号：US13514208
申请日：2010-12-07
Applicant: Dinesh Chikkanna , Mark Gary Bock , Clive McCarthy , Henrik Moebitz , Chetan Pandit , Ramulu Poddutorri
Inventor： Dinesh Chikkanna , Mark Gary Bock , Clive McCarthy , Henrik Moebitz , Chetan Pandit , Ramulu Poddutorri
IPC: A61K31/423 , A61K31/343 , C07D263/56 , C07D307/79
CPC classification number: C07D263/56 , C07D307/79
Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases (e.g., cancer and inflammation).
Abstract translation: 本发明涉及式（I）的化合物及其药学上可接受的盐。 这些化合物已被证明是MEK的抑制剂，因此可用于治疗过度增生性疾病（例如癌症和炎症）。
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公开(公告)号：US20110190334A1
公开(公告)日：2011-08-04
申请号：US12938583
申请日：2010-11-03
Applicant: Mark G. Bock , Dinesh Chikkanna , Clive McCarthy , Henrik Moebitz , Chetan Pandit
Inventor： Mark G. Bock , Dinesh Chikkanna , Clive McCarthy , Henrik Moebitz , Chetan Pandit
IPC: A61K31/437 , C07D471/04 , A61P35/00
CPC classification number: C07D471/04 , C07D498/04 , C07D513/04
Abstract: The present invention relates to compounds of Formula I where R1a, R1b, X, R2a, R2b, W, R3, R4, and R5 are as defined herein as well as pharmaceutically acceptable salts thereof. The compounds have been shown to act as MEK inhibitors which may be useful in the treatment of hyperproliferative diseases, like cancer and inflammation.
Abstract translation: 本发明涉及其中R1a，R1b，X，R2a，R2b，W，R3，R4和R5如本文所定义的式I化合物及其药学上可接受的盐。 已经显示这些化合物作为MEK抑制剂，其可用于治疗过度增殖性疾病如癌症和炎症。
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公开(公告)号：US20140329858A1
公开(公告)日：2014-11-06
申请号：US14361728
申请日：2012-12-03
Applicant: Mark Gary Bock , Dinesh Chikkanna , Marc Gerspacher , Vinayak Khairnar , Bharat Lagu , Chetan Pandit
Inventor： Mark Gary Bock , Dinesh Chikkanna , Marc Gerspacher , Vinayak Khairnar , Bharat Lagu , Chetan Pandit
IPC: C07D235/02 , C07D401/04 , C07D409/04 , C07D491/052 , C07D401/12 , C07D401/06 , C07D401/14 , C07D405/04 , C07D405/12
CPC classification number: C07D235/02 , C07D235/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D491/052
Abstract: The present invention is directed to compounds of formula (I) wherein R1, R2, R3, and A are defined herein. The present invention also provides for pharmaceutical compositions comprising a compound of formula (I) as well as to the use of such compounds as androgen receptor antagonists for the treatment of diseases and conditions mediated by the androgen receptor, such as prostate cancer.
Abstract translation: 本发明涉及其中R 1，R 2，R 3和A如本文所定义的式（I）化合物。 本发明还提供包含式（I）化合物的药物组合物以及这些化合物如雄激素受体拮抗剂用于治疗由雄激素受体介导的疾病和病症如前列腺癌的药物组合物。
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公开(公告)号：US08466289B2
公开(公告)日：2013-06-18
申请号：US12938583
申请日：2010-11-03
Applicant: Mark G. Bock , Dinesh Chikkanna , Clive McCarthy , Henrik Moebitz , Chetan Pandit
Inventor： Mark G. Bock , Dinesh Chikkanna , Clive McCarthy , Henrik Moebitz , Chetan Pandit
IPC: C07D513/04 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4355 , A61K31/4365
CPC classification number: C07D471/04 , C07D498/04 , C07D513/04
Abstract: The present invention relates to compounds of Formula I where R1a, R1b, X, R2a, R2b, W, R3, R4, and R5 are as defined herein as well as pharmaceutically acceptable salts thereof. The compounds have been shown to act as MEK inhibitors which may be useful in the treatment of hyperproliferative diseases, like cancer and inflammation.
Abstract translation: 本发明涉及其中R1a，R1b，X，R2a，R2b，W，R3，R4和R5如本文所定义的式I化合物及其药学上可接受的盐。 已经显示这些化合物作为MEK抑制剂，其可用于治疗过度增殖性疾病，如癌症和炎症。
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公开(公告)号：US20120258973A1
公开(公告)日：2012-10-11
申请号：US13517115
申请日：2010-12-20
Applicant: Sangamesh Babiger , Dirk Behnke , Claudia Betschart , Vinod Chaudhari , Murali Chebrolu , Simona Cotesta , Samuel Hintermann , Arndt Meyer , Chetan Pandit
Inventor： Sangamesh Babiger , Dirk Behnke , Claudia Betschart , Vinod Chaudhari , Murali Chebrolu , Simona Cotesta , Samuel Hintermann , Arndt Meyer , Chetan Pandit
IPC: A61K31/437 , A61P3/00 , A61P25/30 , A61P25/28 , A61K31/4709 , A61K31/506 , A61K31/497 , C07D519/00 , C07D498/04 , A61K31/444 , A61P25/00 , C07D471/04
CPC classification number: C07D471/04 , C07D498/04 , C07D519/00
Abstract: The invention relates to compound of the formula (I′) in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I'）的化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
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