公开(公告)号：US07939650B2

公开(公告)日：2011-05-10

申请号：US11458181

申请日：2006-07-18

Applicant: Diane Pennica ,  Victoria Smith ,  William I. Wood

Inventor： Diane Pennica ,  Victoria Smith ,  William I. Wood

IPC: C07H21/02 ,  C07H21/04 ,  A61K39/00

CPC classification number: C12N15/1034 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/47 ,  C07K2319/00 ,  C12N15/85 ,  G01N33/574 ,  A61K2300/00

Abstract: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及与Stra6，鼠视黄酸反应性蛋白质以及编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07741439B2

公开(公告)日：2010-06-22

申请号：US11438488

申请日：2006-05-22

Applicant: Diane Pennica ,  Victoria Smith ,  William I. Wood

Inventor： Diane Pennica ,  Victoria Smith ,  William I. Wood

IPC: C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K16/00 ,  C08H1/00

CPC classification number: C12N15/1034 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/47 ,  C07K2319/00 ,  C12N15/85 ,  G01N33/574 ,  A61K2300/00

Abstract: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及与Stra6，鼠视黄酸反应性蛋白质以及编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20090182126A1

公开(公告)日：2009-07-16

申请号：US12115428

申请日：2008-05-05

Applicant: Diane Pennica

Inventor： Diane Pennica

IPC: C07K16/18

CPC classification number: C07K14/47 ,  Y10S977/775 ,  Y10S977/924

Abstract: A member of the guanylate-binding protein family, designated GBP-4, is provided. Also provided are isolated nucleic acid encoding GBP-4, vectors and host cells containing such nucleic acid molecule, and a method for producing the GBP-4 recombinantly.

Abstract translation: 提供了称为GBP-4的鸟苷酸结合蛋白家族的成员。 还提供了编码GBP-4的分离的核酸，含有该核酸分子的载体和宿主细胞，以及重组生产GBP-4的方法。

公开(公告)号：US20080206252A1

公开(公告)日：2008-08-28

申请号：US11931835

申请日：2007-10-31

Applicant: Diane Pennica ,  Luca Rastelli

Inventor： Diane Pennica ,  Luca Rastelli

IPC: A61K39/395 ,  C07K14/00 ,  C12N15/11 ,  C12N5/10 ,  G01N33/53 ,  C12Q1/68 ,  A61P35/00 ,  C12Q1/00 ,  C12N15/63 ,  C07K16/00 ,  A61K31/7088

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K48/00

Abstract: An isolated polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence SEQ ID NOS:2, 4, 6 or 8, polynucleotides encoding these peptides, and antibodies to the polypeptides are useful in treating cancers.

Abstract translation: 包含与序列SEQ ID NO：2,4,6或8具有至少80％序列同一性的氨基酸序列的分离的多肽，编码这些肽的多核苷酸和针对该多肽的抗体可用于治疗癌症。

公开(公告)号：US20060275819A1

公开(公告)日：2006-12-07

申请号：US11496778

申请日：2006-07-31

Applicant: Diane Pennica

Inventor： Diane Pennica

IPC: C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12P19/34 ,  C12N9/22

CPC classification number: C07K14/47 ,  Y10S977/775 ,  Y10S977/924

Abstract: A member of the guanylate-binding protein family, designated GBP-4, is provided. Also provided are isolated nucleic acid encoding GBP-4, vectors and host cells containing such nucleic acid molecule, and a method for producing the GBP-4 recombinantly.

公开(公告)号：US06642024B1

公开(公告)日：2003-11-04

申请号：US09643657

申请日：2000-08-17

Applicant: Diane Pennica

Inventor： Diane Pennica

IPC: C12P2106

CPC classification number: C07K14/47 ,  Y10S977/775 ,  Y10S977/924

Abstract: A member of the guanylate-binding protein family, designated GBP-4, is provided. Also provided are isolated nucleic acid encoding GBP-4, vectors and host cells containing such nucleic acid molecule, and a method for producing the GBP-4 recombinantly.

Abstract translation: 提供了称为GBP-4的鸟苷酸结合蛋白家族的成员。 还提供了编码GBP-4的分离的核酸，含有该核酸分子的载体和宿主细胞，以及重组生产GBP-4的方法。

公开(公告)号：US5869314A

公开(公告)日：1999-02-09

申请号：US487456

申请日：1995-06-06

Applicant: David V. Goeddel ,  William J. Kohr ,  Diane Pennica ,  Gordon A. Vehar

Inventor： David V. Goeddel ,  William J. Kohr ,  Diane Pennica ,  Gordon A. Vehar

IPC: A61K38/00 ,  C12N1/21 ,  C12N9/06 ,  C12N9/72 ,  C12N15/58 ,  C12N15/71 ,  C12P20060101 ,  C12N9/64 ,  A61K38/49

CPC classification number: C12N15/71 ,  C12N9/003 ,  C12N9/6459 ,  C12Y304/21069 ,  A61K38/00

Abstract: Tissue plasminogen activators (t-PAs) and derivatives thereof are produced in useful quantities using recombinant DNA techniques. Specific derivatives include amino acid deletion derivatives and amino acid substitution derivatives. A deletion derivative lacking the N-terminal first 68 amino acids is specifically exemplified having requisite t-PA characteristics. The invention disclosed thus enables the production of t-PAs and derivatives thereof via recombinant means. Methods, expression vehicles and various host cells useful in the production of said t-PAs and derivatives thereof are also disclosed.

Abstract translation: 使用重组DNA技术以有用的量产生组织纤溶酶原激活剂（t-PA）及其衍生物。 具体的衍生物包括氨基酸缺失衍生物和氨基酸取代衍生物。 具有必需的t-PA特征的具体示例是缺少N-末端第68个氨基酸的缺失衍生物。 因此，本发明能够通过重组方法生产t-PA及其衍生物。 还公开了可用于生产所述t-PA及其衍生物的方法，表达载体和各种宿主细胞。

公开(公告)号：US5624806A

公开(公告)日：1997-04-29

申请号：US442745

申请日：1995-05-17

Applicant: Joffre Baker ,  Kenneth Chien ,  Kathleen King ,  Diane Pennica ,  William Wood

Inventor： Joffre Baker ,  Kenneth Chien ,  Kathleen King ,  Diane Pennica ,  William Wood

IPC: G01N33/53 ,  A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/19 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/68 ,  C07K16/22 ,  C12N5/12

CPC classification number: C12Q1/025 ,  C07K14/52 ,  G01N33/6872 ,  A01K2217/05 ,  A61K38/00 ,  G01N2500/00 ,  Y10S930/14

Abstract: Isolated CHF, isolated DNA encoding cardiac hypertrophy factor (CHF), and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

Abstract translation: 公开了分离的CHF，编码心脏肥大因子（CHF）的分离的DNA，以及制备CHF的重组或合成方法。 显示这些CHF分子影响增生活性和神经活性。 因此，这些化合物或其拮抗剂可用于治疗心力衰竭，心律不齐症，肌力障碍和神经障碍。

公开(公告)号：US5571893A

公开(公告)日：1996-11-05

申请号：US286304

申请日：1994-08-05

Applicant: Joffre Baker ,  Kenneth Chien ,  Kathleen King ,  Diane Pennica ,  William Wood

Inventor： Joffre Baker ,  Kenneth Chien ,  Kathleen King ,  Diane Pennica ,  William Wood

IPC: A61K38/00 ,  C07K14/52 ,  C12N5/08 ,  C12Q1/02 ,  G01N33/50 ,  G01N33/68 ,  A61K38/19

CPC classification number: G01N33/5008 ,  C07K14/52 ,  C12Q1/025 ,  G01N33/502 ,  G01N33/5026 ,  G01N33/5058 ,  G01N33/5061 ,  G01N33/6872 ,  A01K2217/05 ,  A61K38/00 ,  C07K2317/24 ,  G01N2500/00 ,  Y10S930/14

Abstract: Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed, These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

Abstract translation: 公开了分离的CHF，分离的编码CHF的DNA，以及制备CHF的重组或合成方法，这些CHF分子显示出影响增生活性和神经活性。 因此，这些化合物或其拮抗剂可用于治疗心力衰竭，心律不齐症，肌力障碍和神经障碍。

公开(公告)号：US08350008B2

公开(公告)日：2013-01-08

申请号：US13117051

申请日：2011-05-26

Applicant: David Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

Inventor： David Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

IPC: C12P21/08 ,  C07K16/00 ,  C07K16/18

CPC classification number: C07K14/47 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/74 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.