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公开(公告)号：US07427675B2
公开(公告)日：2008-09-23
申请号：US11209160
申请日：2005-08-22
Applicant: Daniel C. Capaldi , Hans-Joachim Josef Gaus , Claus Andre Frank Rentel , Philip Dmitri Olsen , Christine C. Kurata , Quanlai Song
Inventor： Daniel C. Capaldi , Hans-Joachim Josef Gaus , Claus Andre Frank Rentel , Philip Dmitri Olsen , Christine C. Kurata , Quanlai Song
CPC classification number: C07H21/04
Abstract: The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for characterizing samples useful for making oligonucleotides.
Abstract translation: 本发明涉及寡核苷酸合成。 特别地，本发明提供用于表征可用于制备寡核苷酸的样品的方法。
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公开(公告)号：US07227016B2
公开(公告)日：2007-06-05
申请号：US11024958
申请日：2004-12-28
Applicant: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
Inventor： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC: C07H21/00
Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US07173123B2
公开(公告)日：2007-02-06
申请号：US10679805
申请日：2003-10-06
Applicant: Patrick Wheeler , Daniel C. Capaldi
Inventor： Patrick Wheeler , Daniel C. Capaldi
CPC classification number: C07H21/00 , G01N24/08 , G01R33/44 , G01R33/46 , Y10T436/193333 , Y10T436/196666
Abstract: Methods for detecting chloral hydrate in dichloroacetic acid are described.
Abstract translation: 描述了检测二氯乙酸中水合氯醛的方法。
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14.发明授权公开(公告)号：US06858722B2
公开(公告)日：2005-02-22
申请号：US10444445
申请日：2003-05-23
Applicant: Vasulinga T. Ravikumar , Daniel C. Capaldi , Douglas L. Cole
Inventor： Vasulinga T. Ravikumar , Daniel C. Capaldi , Douglas L. Cole
IPC: C07H21/02 , A61K31/7105 , A61K31/711 , A61K48/00 , A61P9/10 , A61P31/18 , A61P43/00 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04
Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
Abstract translation: 提供合成方法，其中使用亚磷酰胺组合物制备低聚物。 制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯共价键的低聚物，其可以包括其它共价键。 还提供了可用于这些方法的组合物。
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公开(公告)号：US06465628B1
公开(公告)日：2002-10-15
申请号：US09288679
申请日：1999-04-09
Applicant: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
Inventor： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC: C02H2100
Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
Abstract translation: 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯或其它共价键的低聚化合物。 低聚物具有显着减少的衍生自丙烯腈或相关污染物的环加成物。
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Patent Agency Ranking
公开(公告)号：US6040438A
公开(公告)日：2000-03-21
申请号：US104330
申请日：1998-06-25
Applicant: Zacharia S. Cheruvallath , Vasulinga T. Ravikumar , Douglas L. Cole , Daniel C. Capaldi
IPC: C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02
CPC classification number: C07H21/00 , C07C329/14
Abstract: The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
Abstract translation: 本发明涉及通过使含有磷（III）键的寡核苷酸类似物与具有下式的二硫代碳酸二酯多硫化物反应产生硫化寡核苷酸类似物来合成硫化寡核苷酸类似物的方法。 二酯多硫化物试剂可用于溶液和固相寡核苷酸类似物合成。
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公开(公告)号：US5760209A
公开(公告)日：1998-06-02
申请号：US811232
申请日：1997-03-03
Applicant: Zacharia S. Cheruvallath , Daniel C. Capaldi , Vasulinga T. Ravikumar , Douglas L. Cole
IPC: C07C253/00 , C07C255/50 , C07H19/10 , C07H19/20 , C07H21/00 , C07H1/02 , C07H21/02 , C07H21/04
CPC classification number: C07H19/10 , C07C253/00 , C07H19/20 , C07H21/00 , Y02P20/55
Abstract: Nucleoside analog phosphoramidites are provided in which the 3'-hydroxyl group is protected with an 2-N-amidoethyl group. The 2-N-amidoethyl protected nucleoside analogs are useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with the protected phosphoramidites in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl group can be removed easily under standard conditions.
Abstract translation: 提供了核苷类似物亚磷酰胺，其中3'-羟基被2-N-酰氨基乙基保护。 2-N-酰氨基乙基保护的核苷类似物可用于合成多种寡核苷酸类似物。 在溶液或固相寡核苷酸类似物合成中与受保护的亚磷酰胺的偶联产率高，在标准条件下可以容易地除去2-N-酰胺基乙基。
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公开(公告)号：US06858715B2
公开(公告)日：2005-02-22
申请号：US10232881
申请日：2002-08-30
Applicant: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
Inventor： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
Abstract translation: 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯或其它共价键的低聚化合物。 低聚物具有显着减少的衍生自丙烯腈或相关污染物的环加成物。
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公开(公告)号：US06645716B2
公开(公告)日：2003-11-11
申请号：US10059776
申请日：2002-01-29
Applicant: Patrick Wheeler , Daniel C. Capaldi
Inventor： Patrick Wheeler , Daniel C. Capaldi
IPC: C12Q170
CPC classification number: C07H21/00 , G01N24/08 , G01R33/44 , G01R33/46 , Y10T436/193333 , Y10T436/196666
Abstract: Methods for detecting chloral hydrate in dichloroacetic acid are described.
Abstract translation: 描述了检测二氯乙酸中水合氯醛的方法。
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20.发明授权公开(公告)号：US06610842B1
公开(公告)日：2003-08-26
申请号：US09306278
申请日：1999-05-06
Applicant: Vasulinga T. Ravikumar , Daniel C. Capaldi , Douglas L. Cole
Inventor： Vasulinga T. Ravikumar , Daniel C. Capaldi , Douglas L. Cole
IPC: C07H2100
Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
Abstract translation: 提供合成方法，其中使用亚磷酰胺组合物制备低聚物。 制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯共价键的低聚物，其可以包括其它共价键。 还提供了可用于这些方法的组合物。
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