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公开(公告)号：US5989077A
公开(公告)日：1999-11-23
申请号：US39025
申请日：1998-03-13
申请人： Roy T. Mast , Daniel J. Cooke
发明人： Roy T. Mast , Daniel J. Cooke
CPC分类号： A61N1/3752 , H01R4/489 , H01R2201/12
摘要： A header assembly for coupling a cardiac lead to a cardiac stimulator is provided. The header assembly includes a header that has a bore for receiving one end of the cardiac lead. The bore has a first longitudinal axis. A connector housing is coupled to the header and has a second bore substantially aligned with the first bore. A biasing member is disposed within the connector housing and has a portion projecting into the second bore to bias the end of the cardiac lead against the walls of the second bore. A set-screw is threadedly coupled to the housing and is operable to secure the cardiac lead to the connector housing when tightened.
摘要翻译： 提供了用于将心脏引线耦合到心脏刺激器的头部组件。 头部组件包括具有用于接收心脏导联的一端的孔的头部。 孔具有第一纵向轴线。 连接器壳体联接到集管并且具有基本上与第一孔对准的第二孔。 偏置构件设置在连接器壳体内并且具有突出到第二孔中的部分，以将心脏引线的端部抵靠第二孔的壁偏压。 固定螺钉螺纹连接到壳体并且可操作以在紧固时将心脏引线固定到连接器壳体。
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公开(公告)号：US761473A
公开(公告)日：1904-05-31
申请号：US1904187503
申请日：1904-01-02
申请人： JOSEPH WHITE , DANIEL J COOKE , GOODMAN HENRY E
发明人： GOODMAN HENRY E
CPC分类号： E05C1/06 , Y10T292/102 , Y10T292/1028
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公开(公告)号：US08543207B2
公开(公告)日：2013-09-24
申请号：US13178571
申请日：2011-07-08
IPC分类号： A61N1/37
CPC分类号： A61N1/3718 , A61N1/02 , A61N1/36092 , A61N1/3688 , A61N1/3931 , A61N1/3962 , Y10S128/901
摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.
摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。
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公开(公告)号：US20120052184A1
公开(公告)日：2012-03-01
申请号：US13288487
申请日：2011-11-03
申请人： Harshad M. Borgaonkar , Ronald W. Heil, JR. , Arienne P. Simon , Jeannette C. Polkinghorne , Daniel J. Cooke
发明人： Harshad M. Borgaonkar , Ronald W. Heil, JR. , Arienne P. Simon , Jeannette C. Polkinghorne , Daniel J. Cooke
CPC分类号： A61N1/056 , A61N1/0568
摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.
摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并与位于引线主体上的至少一个电极相邻。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。
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公开(公告)号：US20090221885A1
公开(公告)日：2009-09-03
申请号：US12391761
申请日：2009-02-24
申请人： Peter Hall , Daniel J. Cooke , Michael John Kane
发明人： Peter Hall , Daniel J. Cooke , Michael John Kane
IPC分类号： A61B5/1473 , B23K31/02
CPC分类号： A61B5/14542 , A61B5/1473
摘要： Embodiments of the invention are related to optical window assemblies for implantable medical devices, amongst other things. In an embodiment, the invention includes an optical window assembly for a medical device. The assembly can include a ferrule defining an aperture and a spacer ring disposed within the aperture. The assembly can also include an optical window coupled to the metal ferrule and the spacer ring. In an embodiment, the invention includes an implantable medical device including a housing and an optical window assembly coupled to the housing. In an embodiment, the invention can include a method of manufacturing a medical device. The method can include brazing a spacer ring to a metal ferrule, coupling an optical window to the spacer ring and the metal ferrule with a bonding glass material, depositing a chemical sensing element over the optical window, and coupling a porous cover layer to the spacer ring and the ferrule with an adhesive. Other embodiments are also included herein.
摘要翻译： 本发明的实施例涉及用于可植入医疗装置的光学窗组件，其中包括。 在一个实施例中，本发明包括用于医疗装置的光学窗组件。 组件可以包括限定孔的套圈和设置在孔内的间隔环。 组件还可以包括耦合到金属套圈和间隔环的光学窗口。 在一个实施例中，本发明包括可植入医疗装置，其包括壳体和耦合到壳体的光学窗组件。 在一个实施例中，本发明可以包括制造医疗装置的方法。 该方法可以包括将间隔环钎焊到金属套箍上，用光学玻璃材料将光学窗口耦合到间隔环和金属套圈，在光学窗口上沉积化学感测元件，以及将多孔覆盖层耦合到间隔物 环和带有粘合剂的套圈。 本文还包括其它实施例。
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公开(公告)号：US20090138058A1
公开(公告)日：2009-05-28
申请号：US11015807
申请日：2004-12-17
CPC分类号： A61N1/3718 , A61N1/02 , A61N1/36092 , A61N1/3688 , A61N1/3931 , A61N1/3962 , Y10S128/901
摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.
摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。
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17.发明授权公开(公告)号：US09205271B2
公开(公告)日：2015-12-08
申请号：US12563733
申请日：2009-09-21
CPC分类号： A61N1/375 , A61N1/05 , C08L53/00 , C08L75/08 , C08L2666/04 , C08L2666/02
摘要： In accordance with various aspects of the invention, copolymers comprising styrene and isobutylene monomers are used in the construction of implantable and insertable medical devices for electrical stimulation, including, for example, electronic signal generating components and electrical leads for such devices.
摘要翻译： 根据本发明的各个方面，包含苯乙烯和异丁烯单体的共聚物用于构建用于电刺激的可植入和可插入的医疗装置，包括例如电子信号产生组件和用于这种装置的电引线。
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18.发明授权Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置公开(公告)号：US08501831B2
公开(公告)日：2013-08-06
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译： 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。
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19.发明申请公开(公告)号：US20130013040A1
公开(公告)日：2013-01-10
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
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公开(公告)号：US08014867B2
公开(公告)日：2011-09-06
申请号：US11015807
申请日：2004-12-17
IPC分类号： A61N1/37
CPC分类号： A61N1/3718 , A61N1/02 , A61N1/36092 , A61N1/3688 , A61N1/3931 , A61N1/3962 , Y10S128/901
摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.
摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。
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