Abstract:
A computer-implemented system and method for the processing and presentation of aviation information supported by targeted advertising is disclosed. At plurality of flight information is received over a digital network and is stored in at least a database. The database includes aviation information as well as advertisement messages. Upon receiving a user query, a server retrieves a result set from the database and couples it with at least one selected advertisement for presentation to the requesting user. In one form, the results may be presented to the user in the form of digital map having aircraft images and their altitude indicated by an offset shadow. Additionally, the visualization may show only a portion of the path of a flight in the event that multiple flights are displayed in order to preserve readability.
Abstract:
A slider is adapted for use with a reclosable fastener for bags containing material. The reclosable fastener includes a first track and a second track. The first track includes a first profile, while the second track includes a second profile. The first and second profiles are releasably engageable to each other. At least one of the first and second profiles has an interior portion. The slider comprises a body that includes a top, a first side, a second side and a separation member on an underside of the top. The separation member is adapted to open and close the fastener and includes a slider finger that extends generally downwardly from the top. The slider finger extends into an interior portion of the first profile so as to assist in removing material trapped in the interior portion of the first profile when closing the reclosable fastener.
Abstract:
There is provided a peptide that is capable of binding to an MHC class I or II molecule without further processing (i.e., an apitope), which comprises a portion of the region 131-158 of myelin basic protein. In particular, there is provided an apitope which is selected from the following myelin basic protein peptides: 134-148, 135-149, 136-150, 137-151, 138-152, 139-153, 140-154.There is also provided the use of such a peptide in a pharmaceutical composition and a method to treat and/or prevent a disease using such a peptide.
Abstract:
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.
Abstract translation:本发明涉及用于治疗例如性功能障碍的式(I)化合物,其中R 1是任选取代的C 1-6烷基,任选取代的碳环基,任选取代的杂环基,氢,C 1-6烷氧基,-NR 2 R 3或-NR 4 SO 2 R 5; X是键 - (CH 2)n - 或 - (CH 2)Q-O-(其中Y连接至氧); 其中连接X中的一个或多个氢原子可以被C 1-4烷氧基独立地取代; 羟基; 羟基(C 1-3烷基); C 3-7环烷基; 碳环基 杂环基 或被任选被一个或多个氟或苯基取代的C 1-4烷基; n为3,4,5,6或7; q为2,3,4,5或6; Y为苯基或吡啶基,各自可以被取代; 或相邻碳原子上的两个R 8基团与互连碳原子一起可以形成稠合的任选取代的5或6元碳环或杂环基。
Abstract:
A wet connect/disconnect arrangement is disclosed for a downhole system that allows installation of various tools and/or a string and subsequent electrical connection to the downhole system in a wet environment. Several embodiments are disclosed, all of which produce a clean, reliable connection. Exemplary embodiments include an upper section being mechanically and electrically joined to an intermediate section with electrical connectors for being joined at a lower section. The intermediate section further has auxiliary connectors that may be protected by a cover and remain unmated in a first connected application being therefore available for future use. The upper section may be removed leaving the intermediate section in place whereby the unmated connectors are available to rejoin a new upper section. Different types of connectors are also disclosed.
Abstract:
The present invention relates to a method and apparatus for effective inactivation of micro-organisms in fluids with relatively high absorbance so as to limit damage. The apparatus has a large diameter passage (2) flow-through UV radiation system with a static mixer system (11) providing an intensive fluid flow mixing within an irradiation area in which the fluid flow is controlled to provide a flow rate not less than a minimum flow rate corresponding to a maximum fluid residence time within said irradiation area required for efficient mixing, and a maximum flow rate providing a minimum residence time for effective inactivation.
Abstract:
A casing or tubing segment or segments are disclosed which can be used to create a parasite annulus during drilling. The cased wellbore receives a string containing valves and the drillstring operates through it. As the mud circulates, the segments of the tubing or casing provide communication at various depths from the parasite annulus (i.e., the outermost annulus) into the circulating mud, which is the innermost annulus. Each valve is adjustable to alter the amount of differential pressure required in order to open it. The valves are also in hydraulic pressure balance so that only the pressure added by the injected gas acts to open them. The valves close by a spring bias.
Abstract:
A patient interface for delivering breathable gas to a patient includes a nasal prong assembly including a pair of nasal prongs structured to sealingly communicate with nasal passages of a patient's nose in use and headgear to maintain the nasal prong assembly in a desired position on the patient's face. The headgear includes side straps and rigidizers provided to respective side straps. Each rigidizer includes a first end portion that provides a connector structured to engage a respective end of the nasal prong assembly and an inwardly curved protrusion in the form of a cheek support that curves inwardly of the connector. The cheek support is adapted to follow the contour of the patient's cheek and guide a respective end portion of the side strap into engagement with the patient's cheek to provide a stable cheek support.
Abstract:
The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
Abstract:
The present invention relates to novel 2,3,4-substituted 5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridine compounds and pharmaceutically acceptable salts thereof, to compositions containing such compounds and to the use of such compounds as inhibitors of HIV replication.