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公开(公告)号：US08084233B2
公开(公告)日：2011-12-27
申请号：US12971626
申请日：2010-12-17
Applicant: Jill Giles-Komar , David M. Knight , David Peritt , Bernard Scallon , David Shealy
Inventor： Jill Giles-Komar , David M. Knight , David Peritt , Bernard Scallon , David Shealy
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.
Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生抗体或用于治疗和/或诊断IL-12相关病症和疾病的部分。
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12.发明申请Anti-IL-12/23p40 Antibodies, Epitopes, Formulations, Compositions, Methods and Uses 审中-公开抗IL-12 / 23p40抗体，表位，制剂，组合物，方法和用途公开(公告)号：US20090181027A1
公开(公告)日：2009-07-16
申请号：US12238804
申请日：2008-09-26
Applicant: Paul Dal Monte , Jill Giles-Komar , George Heavner , David Knight , Mehrnaz Khossravi , Jinquan Luo , David Shealy , David Volkin
Inventor： Paul Dal Monte , Jill Giles-Komar , George Heavner , David Knight , Mehrnaz Khossravi , Jinquan Luo , David Shealy , David Volkin
IPC: A61K39/395 , A61P43/00
CPC classification number: A61K47/26 , A61K47/183 , A61K2039/505 , C07K16/244 , C07K2317/34 , C07K2317/76
Abstract: An anti-IL-12/23p40 antibody that binds to a portion of the IL-12 or IL-23 protein corresponding to the p40 subunit of IL-12 or IL-23, including compositions, formulations, and methods of administration have applications in diagnostic and/or therapeutic uses and devices.
Abstract translation: 结合与IL-12或IL-23的p40亚基相对应的IL-12或IL-23蛋白的一部分的抗IL-12 / 23p40抗体，包括组合物，制剂和施用方法，可应用于 诊断和/或治疗用途和装置。
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公开(公告)号：US07521206B2
公开(公告)日：2009-04-21
申请号：US11180219
申请日：2005-07-13
Applicant: George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
Inventor： George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
IPC: C12N15/13 , C12N15/63 , C12N1/11 , C12N1/13 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/16
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
Abstract: The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
Abstract translation: 本发明涉及至少一种新的抗TNF抗体，包括编码至少一种抗TNF抗体，TNF，载体，宿主细胞，转基因动物或植物的分离核酸及其制备和使用方法，包括治疗 组合物，方法和装置。
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14.发明申请ANTI-TNF ANTIBODIES, COMPOSITIONS, METHODS AND USES FOR TREATMENT OF DEPRESSION AND RELATED CONDITIONS 审中-公开抗TNF抗体，组合物，治疗抑郁症及相关病症的方法和用途公开(公告)号：US20090081234A1
公开(公告)日：2009-03-26
申请号：US12274386
申请日：2008-11-20
Applicant: George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
Inventor： George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
IPC: A61K39/395 , C12N5/00 , A61P25/24
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/567 , C07K2317/76 , Y02A50/412
Abstract: The present invention relates to novel anti-TNF antibodies for use in the treatment of depression, including therapeutic compositions, methods and devices.
Abstract translation: 本发明涉及用于治疗抑郁症的新型抗TNF抗体，包括治疗组合物，方法和装置。
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15.发明申请公开(公告)号：US20070160606A1
公开(公告)日：2007-07-12
申请号：US11240275
申请日：2005-09-30
Applicant: George Heavner , Jill Giles-Komar , David Knight , Bernard Scallon , David Shealy
Inventor： George Heavner , Jill Giles-Komar , David Knight , Bernard Scallon , David Shealy
IPC: A61K39/395 , A61K38/19 , A61K38/17
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/92
Abstract: The present invention relates to at least one novel anti-TNF antibody, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices, including the treatment of renal cell carcinoma.
Abstract translation: 本发明涉及至少一种新的抗TNF抗体，包括编码至少一种抗TNF抗体，TNF，载体，宿主细胞，转基因动物或植物的分离核酸及其制备和使用方法，包括治疗 组合物，方法和装置，包括治疗肾细胞癌。
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Patent Agency Ranking
公开(公告)号：US20050123541A1
公开(公告)日：2005-06-09
申请号：US10954900
申请日：2004-09-30
Applicant: George Heavner , David Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
Inventor： George Heavner , David Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
IPC: C12N15/09 , A61K20060101 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P20060101 , A61P35/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C07K16/42 , C12N20060101 , C12N5/10 , C12N15/13 , C12P21/08 , G01N20060101 , A61K31/573 , A61K31/473 , A61K31/137
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
Abstract: The present invention relates to methods for treating carcinomas or adenocarcinomas using at least one anti-TNF antibody.
Abstract translation: 本发明涉及使用至少一种抗TNF抗体治疗癌或腺癌的方法。
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公开(公告)号：US06902734B2
公开(公告)日：2005-06-07
申请号：US09920262
申请日：2001-08-01
Applicant: Jill Giles-Komar , David M. Knight , David Peritt , Bernard Scallon , David Shealy
Inventor： Jill Giles-Komar , David M. Knight , David Peritt , Bernard Scallon , David Shealy
IPC: A01H1/00 , A01K67/027 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P20060101 , A61P17/06 , A61P25/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N20060101
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to at least one anti-IL-12 antibody, including isolated nucleic acids that encode at least one anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
Abstract translation: 本发明涉及至少一种抗IL-12抗体，包括编码至少一种抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备和 包括治疗组合物，方法和装置。
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公开(公告)号：US5753628A
公开(公告)日：1998-05-19
申请号：US482009
申请日：1995-06-07
Applicant: George A. Heavner , Marian Kruszynski , David Shealy
Inventor： George A. Heavner , Marian Kruszynski , David Shealy
Abstract: Peptides which consist of six to eight, predominately D-amino acids and which bind to tumor necrosis factor-alpha, prevent tumor necrosis factor-alpha from binding to its receptors and inhibit tumor necrosis factor-alpha activity are disclosed. Methods of inhibiting tumor necrosis factor-alpha activity and of treating individuals suffering from tumor necrosis factor-alpha-mediated diseases and disorders are disclosed.
Abstract translation: 公开了由6-8个主要D-氨基酸组成并且与肿瘤坏死因子-α结合的肽，其阻止肿瘤坏死因子-α与其受体结合并抑制肿瘤坏死因子-α活性。 公开了抑制肿瘤坏死因子-α活性和治疗患有肿瘤坏死因子-α介导的疾病和病症的个体的方法。
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19.发明授权公开(公告)号：US08329170B2
公开(公告)日：2012-12-11
申请号：US13299831
申请日：2011-11-18
Applicant: Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
Inventor： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC: A61K39/395
CPC classification number: C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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公开(公告)号：US20120282170A1
公开(公告)日：2012-11-08
申请号：US13547557
申请日：2012-07-12
Applicant: George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
Inventor： George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
IPC: A61K39/395 , C12N15/63 , C12N5/10 , C12P21/02 , C07K16/42 , C12N5/071 , G01N33/566 , A61K51/00 , C12N1/00 , G01N33/577 , A61P29/00 , A61P21/02 , A61P23/00 , A61P25/20 , A61P31/00 , A61P17/06 , A61P37/04 , A61P37/06 , A61P25/24 , A61P25/18 , A61P11/06 , C12N15/13
CPC classification number: C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
Abstract translation: 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
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