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    Method of preparing alkyl butyrate from fermented liquid using microorganisms
    12.
    发明授权
    Method of preparing alkyl butyrate from fermented liquid using microorganisms 有权
    使用微生物从发酵液制备丁酸丁酯的方法

    公开(公告)号：US09034614B2

    公开(公告)日：2015-05-19

    申请号：US13821109

    申请日：2011-09-08

    申请人： Sin Young Kang ,  Min Su Koo ,  In Ho Cho ,  Joon Sik Lee ,  Eun Hee Park ,  Joong Min Park ,  Jae Yeon Park ,  Young Hwan Chu ,  Dong Hyun Kim ,  Woo Chan Park ,  Seung Yeop Lee ,  Jae Wook Ryu

    发明人： Sin Young Kang ,  Min Su Koo ,  In Ho Cho ,  Joon Sik Lee ,  Eun Hee Park ,  Joong Min Park ,  Jae Yeon Park ,  Young Hwan Chu ,  Dong Hyun Kim ,  Woo Chan Park ,  Seung Yeop Lee ,  Jae Wook Ryu

    IPC分类号： C12P7/62 ,  C07C51/02 ,  C07C51/48 ,  C12P7/52

    CPC分类号： C12P7/62 ,  C07C51/02 ,  C07C51/48 ,  C12P7/52 ,  C07C53/124

    摘要： Disclosed is a method of preparing alkyl butyrate, which comprises: (a) producing a fermented liquid containing butyrate salt through a fermentation process using butyric acid-producing strains; (b) obtaining an extracted liquid containing butyric acid from a continuous extracting apparatus using an extraction solvent, after converting the butyrate salt into butyric acid by adding an inorganic acid except for carbonic acid or carbon dioxide into the fermented liquid, wherein the continuous extracting apparatus includes a plurality of extraction plates which are installed inside an extraction column and perform a reciprocating motion vertically, and the broth and the extraction solvent are supplied to upper and lower portions of the column, respectively; and (c) reacting the extracted liquid and alcohol having a carbon number of 4 or less or a mixture thereof in an esterification reactor to convert a resultant product into alkyl butyrate. According to the present invention, butyric acid existing in microbic culture fluid can be efficiently extracted, and furthermore, competitively priced alkyl butyrate can be prepared without an additional process of separating the extracted solvent while minimizing energy consumption.

    摘要翻译： 公开了一种制备丁酸丁酯的方法，其包括：（a）通过使用产酸菌株的发酵过程生产含有丁酸盐的发酵液; （b）使用提取溶剂从连续提取装置中得到含有丁酸的提取液，在向所述发酵液中添加除了碳酸或二氧化碳以外的无机酸而将所述丁酸盐转化为丁酸后，连续提取装置 包括多个提取板，它们安装在提取塔内部并且垂直地进行往复运动，并且将肉汤和提取溶剂分别供应到塔的上部和下部; 和（c）使碳数为4以下的提取液和醇或其混合物在酯化反应器中反应，将所得产物转化为丁酸烷基酯。 根据本发明，可以有效地提取存在于微生物培养液中的丁酸，此外，可以制备竞争价格的丁酸丁酯，而不需要额外的分离萃取溶剂的方法，同时最小化能量消耗。

    METHOD OF PREPARING ALKYL BUTYRATE FROM FERMENTED LIQUID USING MICROORGANISMS
    14.
    发明申请
    METHOD OF PREPARING ALKYL BUTYRATE FROM FERMENTED LIQUID USING MICROORGANISMS 有权
    使用微生物从发酵液中制备丙烯酸丁酯的方法

    公开(公告)号：US20130164801A1

    公开(公告)日：2013-06-27

    申请号：US13821109

    申请日：2011-09-08

    申请人： Sin Young Kang ,  Min Su Koo ,  In Ho Cho ,  Joon Sik Lee ,  Eun Hee Park ,  Joong Min Park ,  Jae Yeon Park ,  Young Hwan Chu ,  Dong Hyun Kim ,  Woo Chan Park ,  Seung Yeop Lee ,  Jae Wook Ryu

    发明人： Sin Young Kang ,  Min Su Koo ,  In Ho Cho ,  Joon Sik Lee ,  Eun Hee Park ,  Joong Min Park ,  Jae Yeon Park ,  Young Hwan Chu ,  Dong Hyun Kim ,  Woo Chan Park ,  Seung Yeop Lee ,  Jae Wook Ryu

    IPC分类号： C12P7/62

    CPC分类号： C12P7/62 ,  C07C51/02 ,  C07C51/48 ,  C12P7/52 ,  C07C53/124

    摘要： Disclosed is a method of preparing alkyl butyrate, which comprises: (a) producing a fermented liquid containing butyrate salt through a fermentation process using butyric acid-producing strains; (b) obtaining an extracted liquid containing butyric acid from a continuous extracting apparatus using an extraction solvent, after converting the butyrate salt into butyric acid by adding an inorganic acid except for carbonic acid or carbon dioxide into the fermented liquid, wherein the continuous extracting apparatus includes a plurality of extraction plates which are installed inside an extraction column and perform a reciprocating motion vertically, and the broth and the extraction solvent are supplied to upper and lower portions of the column, respectively; and (c) reacting the extracted liquid and alcohol having a carbon number of 4 or less or a mixture thereof in an esterification reactor to convert a resultant product into alkyl butyrate. According to the present invention, butyric acid existing in microbic culture fluid can be efficiently extracted, and furthermore, competitively priced alkyl butyrate can be prepared without an additional process of separating the extracted solvent while minimizing energy consumption.

    摘要翻译： 公开了一种制备丁酸丁酯的方法，其包括：（a）通过使用产酸菌株的发酵过程生产含有丁酸盐的发酵液; （b）使用提取溶剂从连续提取装置中得到含有丁酸的提取液，在向所述发酵液中添加除了碳酸或二氧化碳以外的无机酸而将所述丁酸盐转化为丁酸后，连续提取装置 包括多个提取板，它们安装在提取塔内部并且垂直地进行往复运动，并且将肉汤和提取溶剂分别供应到塔的上部和下部; 和（c）使碳数为4以下的提取液和醇或其混合物在酯化反应器中反应，将所得产物转化为丁酸烷基酯。 根据本发明，可以有效地提取存在于微生物培养液中的丁酸，此外，可以制备竞争价格的丁酸丁酯，而不需要额外的分离萃取溶剂的方法，同时最小化能量消耗。

    METHOD OF PREPARAING ENTERIC HARD CAPSULE AND ENTERIC HARD CAPSULE PREPARED THEREBY
    15.
    发明申请
    METHOD OF PREPARAING ENTERIC HARD CAPSULE AND ENTERIC HARD CAPSULE PREPARED THEREBY 有权
    制备肠溶硬胶囊和肠内硬化胶囊的方法

    公开(公告)号：US20130072579A1

    公开(公告)日：2013-03-21

    申请号：US13634590

    申请日：2011-02-21

    申请人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    发明人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    IPC分类号： A61K47/38

    CPC分类号： A61K47/38 ,  A61J3/077 ,  A61K9/4816

    摘要： A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.

    摘要翻译： 制备肠溶硬胶囊的方法和通过该方法制备的肠溶硬胶囊。 该方法可以包括：在室温下将肠溶基质材料，胶囊形成助剂和中和剂溶于水中以制备含水组合物; 将所述水性组合物加热到高于所述水性组合物的凝胶化开始温度的第一温度; 将加热的水性组合物冷却至低于凝胶化开始温度的第二温度; 将加热到高于凝胶化开始温度的第三温度的模具针浸入水性组合物中; 从水性组合物中取出模具销以获得涂在模具销上的薄膜; 在第一温度高于第一时间的凝胶化开始温度的第四温度下将薄膜保持在模具销上，以将薄膜固定在模具销上; 并在第五温度下将固定膜干燥第二时间以获得胶囊壳。

    USER INPUT APPARATUS FOR CONTROLLING IMAGE DISPLAY DEVICE AND METHOD OF CONTROLLING THE IMAGE DISPLAY DEVICE BY USING THE USER INPUT APPARATUS
    16.
    发明申请
    USER INPUT APPARATUS FOR CONTROLLING IMAGE DISPLAY DEVICE AND METHOD OF CONTROLLING THE IMAGE DISPLAY DEVICE BY USING THE USER INPUT APPARATUS 审中-公开
    用于控制图像显示装置的用户输入装置和使用用户输入装置控制图像显示装置的方法

    公开(公告)号：US20090237368A1

    公开(公告)日：2009-09-24

    申请号：US12266046

    申请日：2008-11-06

    申请人： Chang-hwan HWANG ,  Seung-dong YU ,  Woo-yong CHANG ,  Ju-il EOM ,  Eun-hee PARK

    发明人： Chang-hwan HWANG ,  Seung-dong YU ,  Woo-yong CHANG ,  Ju-il EOM ,  Eun-hee PARK

    IPC分类号： G06F3/041

    CPC分类号： G06F3/017 ,  G06F3/03547

    摘要： Provided is a user input apparatus for controlling an image display device including: a first input unit receiving an instruction to perform a predetermined function of controlling the image display device when a discontinuous signal is received; a second input unit coupled to the first input unit and receiving an instruction to perform a predetermined function of controlling the image display device when a continuous signal is received; and a controller generating a control signal for performing a second function in conjunction with a first function in the image display device when the continuous signal is received from the second input unit within a predetermined period of time after an instruction to perform the first function of controlling the image display device is received from the first input unit.

    摘要翻译： 提供一种用于控制图像显示装置的用户输入装置，包括：第一输入单元，当接收到不连续信号时，接收执行控制图像显示装置的预定功能的指令; 第二输入单元，耦合到第一输入单元，并且当接收到连续信号时，接收执行控制图像显示装置的预定功能的指令; 以及控制器，当在执行控制的第一功能的指令之后的预定时间段内，当从第二输入单元接收到连续信号时，生成用于与图像显示装置中的第一功能一起执行第二功能的控制信号 从第一输入单元接收图像显示装置。

    Method of preparing enteric hard capsule and enteric hard capsule prepared thereby
    17.
    发明授权
    Method of preparing enteric hard capsule and enteric hard capsule prepared thereby 有权
    制备肠溶硬胶囊和肠溶硬胶囊的方法

    公开(公告)号：US08710105B2

    公开(公告)日：2014-04-29

    申请号：US13634590

    申请日：2011-02-21

    申请人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    发明人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    IPC分类号： A61K47/38

    CPC分类号： A61K47/38 ,  A61J3/077 ,  A61K9/4816

    摘要： A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.

    摘要翻译： 制备肠溶硬胶囊的方法和通过该方法制备的肠溶硬胶囊。 该方法可以包括：在室温下将肠溶基质材料，胶囊形成助剂和中和剂溶于水中以制备含水组合物; 将所述水性组合物加热到高于所述水性组合物的凝胶化开始温度的第一温度; 将加热的水性组合物冷却至低于凝胶化开始温度的第二温度; 将加热到高于凝胶化开始温度的第三温度的模具针浸入水性组合物中; 从水性组合物中取出模具销以获得涂在模具销上的薄膜; 在第一温度高于第一时间的凝胶化开始温度的第四温度下将薄膜保持在模具销上，以将薄膜固定在模具销上; 并在第五温度下将固定膜干燥第二时间以获得胶囊壳。

    BLOOD CORPUSCLE SEPARATION CHIP
    18.
    发明申请
    BLOOD CORPUSCLE SEPARATION CHIP 审中-公开
    血液股份分离芯片

    公开(公告)号：US20120329148A1

    公开(公告)日：2012-12-27

    申请号：US13578940

    申请日：2011-03-10

    申请人： Daesung Hur ,  Jong Hyun Oh ,  Jae Jeong Kim ,  Eun Hee Park ,  Ji Young Park

    发明人： Daesung Hur ,  Jong Hyun Oh ,  Jae Jeong Kim ,  Eun Hee Park ,  Ji Young Park

    IPC分类号： C12M1/26

    CPC分类号： B01L3/502753 ,  B01D63/088 ,  B01D2313/025 ,  B01D2313/08 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/161 ,  B01L2400/0406

    摘要： A corpuscle separation chip is presented, which is capable of separating plasma from blood using capillary forces without causing leakage of the blood in undesired directions. The corpuscle separation chip may include an upper board for securing a membrane such that one or more edges maintain non-contact, where a portion of a channel is formed in the upper board to provide a path causing plasma components separated by the membrane from blood to move in one direction; and a lower board in which another portion of the channel is formed, where the lower board is configured to join with the upper board to form the channel, and the lower board is configured to cause the plasma components to move along the channel due to capillary forces at a position corresponding to one side of a lower surface of the membrane. By using such corpuscle separation chip, each of the edges of the membrane can maintain as much non-contact as possible with the structure formed by an upper board and a lower board attached to each other, to prevent leakage of the loaded blood in undesired directions.

    摘要翻译： 提出了一种微粒分离芯片，其能够使用毛细管力将血浆从血液分离，而不会导致血液在不期望的方向上泄漏。 微粒分离芯片可以包括用于固定膜的上板，使得一个或多个边缘保持非接触，其中在上板中形成通道的一部分以提供使由膜隔离的血液成分从血液分离的路径 向一个方向移动 以及下板，其中所述通道的另一部分形成，其中所述下板被配置为与所述上板接合以形成所述通道，并且所述下板被配置为使得所述等离子体部件由于毛细管而沿着所述通道移动 在与膜的下表面的一侧对应的位置处的力。 通过使用这样的微粒分离芯片，膜的每个边缘可以保持尽可能多的非接触，由彼此附接的上板和下板形成的结构，以防止加载的血液在不期望的方向上泄漏 。

    AQUEOUS COMPOSITION FOR ENTERIC HARD CAPSULE, METHOD OF PREPARING ENTERIC HARD CAPSULE, AND ENTERIC HARD CAPSULE PREPARED USING THE METHOD
    20.
    发明申请
    AQUEOUS COMPOSITION FOR ENTERIC HARD CAPSULE, METHOD OF PREPARING ENTERIC HARD CAPSULE, AND ENTERIC HARD CAPSULE PREPARED USING THE METHOD 有权
    肠型硬胶囊的水性组合物，制备肠型硬胶囊的方法和使用该方法制备的肠梗阻

    公开(公告)号：US20120161364A1

    公开(公告)日：2012-06-28

    申请号：US13378249

    申请日：2009-10-13

    申请人： Jin Ryul Son ,  Hyon Ho Baek ,  Sung Wan Lee ,  Min Gyu Song ,  Jae Uk Cha ,  Eun Hee Park

    发明人： Jin Ryul Son ,  Hyon Ho Baek ,  Sung Wan Lee ,  Min Gyu Song ,  Jae Uk Cha ,  Eun Hee Park

    IPC分类号： C08L1/10 ,  B28B1/38 ,  C08L1/14

    CPC分类号： A61K9/4816 ,  A61K47/38

    摘要： An aqueous composition for an enteric hard capsule, a method of preparing an enteric hard capsule, and an enteric hard capsule prepared using the method. The aqueous composition for an enteric hard capsule includes an enteric base material, a capsule forming aid, and a neutralizing agent. The method of preparing an enteric hard capsule includes: preparing an aqueous composition by dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water; preheating the aqueous composition to a temperature that is less than the gelation temperature for the aqueous composition; immersing a mold pin heated to a temperature that is greater than the gelation temperature for the aqueous composition into the aqueous composition; taking the mold pin out of the aqueous composition to obtain a film formed on the mold pin; and maintaining the film at a temperature that is equal to or greater than the gelation temperature for the aqueous composition for a predetermined period of time to fix the film on the mold pin and drying the film.

    摘要翻译： 肠溶硬胶囊的水性组合物，制备肠溶性硬胶囊的方法以及使用该方法制备的肠溶性硬胶囊。 用于肠溶硬胶囊的水性组合物包括肠溶基质材料，胶囊形成助剂和中和剂。 制备肠溶性硬胶囊的方法包括：通过将肠溶基质材料，胶囊形成助剂和中和剂溶解在水中来制备水性组合物; 将含水组合物预热至低于水性组合物的凝胶化温度的温度; 将模具针浸入加热到水性组合物的水凝胶化温度以上的温度下， 将模具针从水性组合物中取出以获得在模具销上形成的膜; 并将膜维持在等于或大于水性组合物凝胶化温度一段预定时间的温度以将膜固定在模具销上并干燥该膜。