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    2,3,4,9-tetrahydro beta carboline derivatives, useful as antihypertensive agents
    15.
    发明授权
    2,3,4,9-tetrahydro beta carboline derivatives, useful as antihypertensive agents 失效
    2,3,4,9-四氢β-咔啉衍生物，可用作抗高血压药

    公开(公告)号：US4683238A

    公开(公告)日：1987-07-28

    申请号：US749473

    申请日：1985-06-27

    申请人： Gerd Schnorrenberg ,  Otto Roos ,  Walter Losel ,  Ingrid Wiedemann ,  Wolfram Gaida ,  Wolfgang Hoefke

    发明人： Gerd Schnorrenberg ,  Otto Roos ,  Walter Losel ,  Ingrid Wiedemann ,  Wolfram Gaida ,  Wolfgang Hoefke

    IPC分类号： A61K31/435 ,  A61K38/00 ,  A61P7/10 ,  A61P9/12 ,  C07D471/04 ,  C07D495/04 ,  C07K5/02 ,  A61K31/40

    CPC分类号： C07D471/04 ,  C07D495/04 ,  C07K5/0222 ,  A61K38/00

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m are each independently 0, 1 or 2, the sum of n and m being 1 or 2;X, Y and Z are each independently oxygen, sulfur, --NR.sub.4 --, .dbd.CR.sub.5 --, --CHR.sub.5 --, ##STR2## provided that only one of X, Y and Z is O, S ##STR3## and one or two of X, Y and Z are --NR.sub.4 --; R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms; andR.sub.5 is hydrogen or, together with a vicinal radical R.sub.5, a phenyl ring, or when m and n are both 1, the dihydro form with its double bond in conjugation with the C-terminal carboxylic group;or a non-toxic, pharmacologically acceptable salt thereof. The compounds as well as their salts are useful as antihypertensives.

    摘要翻译： 其中R 1是氢，1至6个碳原子的烷基或苯基（1至6个碳原子的烷基）的式 R2是氢，1至4个碳原子的烷基或苯基（1至6个碳原子的烷基）; R3是氢或1至6个碳原子的烷基; n和m各自独立地为0,1或2，n和m的和为1或2; X，Y和Z各自独立地为氧，硫，-NR4-，= CR5-，-CHR5-，，条件是X，Y和Z中只有一个是O，S 和X中的一个或两个 ，Y和Z是-NR 4 - ; R4是氢或1-4个碳原子的烷基; 并且R 5是氢或与连位基R5一起为苯环，或者当m和n均为1时，与C末端羧基共轭的双键形式的二氢形式; 或其无毒的药理学上可接受的盐。 化合物及其盐可用作抗高血压药。