公开(公告)号：US20220105060A1

公开(公告)日：2022-04-07

申请号：US17429683

申请日：2020-02-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Tatsuya SAKAKURA ,  Satoshi KIMURA ,  Seiichiro TSURU

IPC: A61K31/192 ,  A61K31/045 ,  A61K9/70 ,  A61K47/10

Abstract: The present invention provides a gel patch having a paste layer on a support, wherein the paste layer comprising ketoprofen or a pharmaceutically acceptable salt thereof, propylene glycol, 1-menthol, and water, wherein the mass of propylene glycol in the paste layer is 3-fold the mass of ketoprofen or less, and wherein the content of 1-menthol based on a total mass of the paste layer is 0.1 to 0.5 mass %.

公开(公告)号：US11033511B2

公开(公告)日：2021-06-15

申请号：US16610955

申请日：2018-07-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Akira Shuto ,  Takao Kurokawa ,  Junya Horiuchi ,  Hidekazu Kuma ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/216

Abstract: The present invention provides a patch comprising a backing, and an adhesive layer on the backing, wherein the adhesive layer contains at least one drug selected from the group consisting of oxybutynin and a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive base, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0007 to 0.05% by mass based on the total mass of the adhesive layer.

公开(公告)号：US11033458B2

公开(公告)日：2021-06-15

申请号：US16061866

申请日：2016-12-01

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yusuke Shirotani ,  Kazuki Kuriyama ,  Seiji Tokumoto

IPC: A61J1/14 ,  A61J1/10 ,  A61M5/152 ,  A61M5/158 ,  A61M5/165 ,  A61M5/168 ,  A61M5/142 ,  A61M39/22

Abstract: A liquid bag according to one embodiment stores liquid containing an active ingredient to be transdermally administered. This liquid bag includes a bag body configured to store the liquid and feed the liquid toward an injection needle. The bag body includes a tubular portion. At least part of the tubular portion is bent with respect to the axial direction of the tubular portion with the liquid being stored in the tubular portion.

公开(公告)号：US11007358B2

公开(公告)日：2021-05-18

申请号：US16325325

申请日：2017-08-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki Yamamoto ,  Seiji Tokumoto

IPC: A61M37/00 ,  A61K47/36 ,  A61K9/00

Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.

公开(公告)号：US10806705B2

公开(公告)日：2020-10-20

申请号：US15745266

申请日：2016-07-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takashi Yasukochi ,  Atsushi Sonobe ,  Satoshi Amano

IPC: A61K47/18 ,  A61K9/70 ,  A61K31/407 ,  A61K47/14

Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.

公开(公告)号：US20200316355A1

公开(公告)日：2020-10-08

申请号：US16767290

申请日：2018-11-06

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya TAJIMA ,  Naoki YAMAMOTO ,  Seiji TOKUMOTO

IPC: A61M37/00

Abstract: An application kit according to one embodiment includes: a cartridge including a sheet member; and an applicator being connectable to the cartridge. The cartridge includes a bending portion configured to bend the sheet member and a cartridge-side connector configured to be detachably connected to the applicator. The applicator includes: an applicator body; an applicator-side connector provided to a bottom portion of the applicator body; a cap provided above the applicator body and being movable along a height direction of the applicator body; and an elastic member extending along the height direction between the applicator body and the cap and configured to apply, to the cap, an elastic force that acts in a direction away from the bottom portion.

公开(公告)号：US10441551B2

公开(公告)日：2019-10-15

申请号：US15769393

申请日：2016-10-24

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi Sonobe ,  Akio Takeuchi ,  Yasunori Takada

IPC: A61K9/70 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K47/32 ,  A61K47/44 ,  A61K31/4468

Abstract: A patch comprises a backing and an adhesive layer laminated on at least one surface of the backing, in which the adhesive layer contains at least one selected from the group consisting of fentanyl and salts thereof, and contains an adhesive base material and an antioxidant having a sulfur atom in its molecule.

公开(公告)号：US10307381B2

公开(公告)日：2019-06-04

申请号：US15518847

申请日：2015-10-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Junji Noguchi ,  Eisuke Hatanaka ,  Hisakazu Kurita ,  Ryusuke Fudoji ,  Yasunari Michinaka

IPC: A61K31/485 ,  A61K9/70 ,  A61K47/10 ,  A61K31/00 ,  A61K47/06 ,  C08F226/02 ,  C08F226/10 ,  C08K5/092

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

公开(公告)号：US20190161647A1

公开(公告)日：2019-05-30

申请号：US16263525

申请日：2019-01-31

Applicant: TOPPAN PRINTING CO., LTD. ,  HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Koji SAKAIRI ,  Atsushi MATSUSHIMA ,  Tomohiro SHINODA ,  Atsushi SONOBE

IPC: C09J7/29 ,  C09J201/02

Abstract: A support film for a tape material, includes a film-shaped support formed of polyurethane; and a barrier layer containing an aromatic isocyanate-based polyurethane and a layered inorganic compound and formed on one surface of the support.

公开(公告)号：US20190105391A1

公开(公告)日：2019-04-11

申请号：US16209084

申请日：2018-12-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K47/12 ,  A61K31/407 ,  A61K31/55 ,  A61K47/10 ,  A61M37/00 ,  A61K9/70 ,  A61K47/14 ,  A61K47/06

Abstract: A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cmax of free asenapine is in range of 0.5 to 6.0 ng/mL and tmax of free asenapine is in range of 8 to 28 hr.