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公开(公告)号：US20100324059A1
公开(公告)日：2010-12-23
申请号：US12818407
申请日：2010-06-18
Applicant: William E. Delaney , Hongmei Mo , Weidong Zhong
Inventor： William E. Delaney , Hongmei Mo , Weidong Zhong
IPC: A61K31/501 , A61P31/14
CPC classification number: A61K9/2004 , A61K9/08 , A61K31/497 , A61K31/501 , A61K45/06 , A61K2300/00
Abstract: This invention relates to combinations of Compound 1 and Compound 2 which are useful for treating hepatitis C virus infection.
Abstract translation: 本发明涉及可用于治疗丙型肝炎病毒感染的化合物1和化合物2的组合。
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公开(公告)号：US20070232645A1
公开(公告)日：2007-10-04
申请号：US11613836
申请日：2006-12-20
Applicant: Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
Inventor： Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
IPC: A61K31/4375 , C07D471/02 , C12N7/06
CPC classification number: C07D471/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：US20070232627A1
公开(公告)日：2007-10-04
申请号：US11613810
申请日：2006-12-20
Applicant: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
Inventor： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC: A61K31/519 , A61K31/4375 , C07D239/70 , C07D471/02 , C12N7/06
CPC classification number: C07D471/04 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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Patent Agency Ranking
公开(公告)号：US08889849B2
公开(公告)日：2014-11-18
申请号：US13542554
申请日：2012-07-05
Applicant: William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
Inventor： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
IPC: C12Q1/70 , C12Q1/66 , C12N15/86 , C12N5/10 , C12N5/071 , C07K14/005 , G01N33/576 , C12Q1/68 , C12N15/64 , C12N15/65
CPC classification number: C12N15/86 , C07K14/005 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , G01N33/5767 , G01N2333/186
Abstract: Replicons of genotype 4 hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 4 replicons and methods of using these replicons to screen antiviral agents are also provided.
Abstract translation: 提供基因型4丙型肝炎病毒（HCV）的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型4复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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公开(公告)号：US08889848B2
公开(公告)日：2014-11-18
申请号：US13542551
申请日：2012-07-05
Applicant: William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
Inventor： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
IPC: C12Q1/70 , C12Q1/66 , C12N15/86 , C12N5/10 , C12N5/071 , C07K14/005 , C12Q1/68 , C12N15/64 , C12N15/65
CPC classification number: C07K14/005 , C12N15/86 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , C12Q1/707 , G01N2333/186 , G01N2333/9513 , G01N2500/00
Abstract: Replicons of genotype 3 of hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 3 replicons and methods of using these replicons to screen antiviral agents are also provided.
Abstract translation: 提供丙型肝炎病毒（HCV）基因型3的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型3复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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公开(公告)号：US20130052634A1
公开(公告)日：2013-02-28
申请号：US13542554
申请日：2012-07-05
Applicant: William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
Inventor： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
CPC classification number: C12N15/86 , C07K14/005 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , G01N33/5767 , G01N2333/186
Abstract: Replicons of genotype 4 hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 4 replicons and methods of using these replicons to screen antiviral agents are also provided.
Abstract translation: 提供基因型4丙型肝炎病毒（HCV）的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型4复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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公开(公告)号：US07910595B2
公开(公告)日：2011-03-22
申请号：US11613810
申请日：2006-12-20
Applicant: David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
Inventor： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
IPC: C07D471/04 , A01N31/519 , A61P31/12
CPC classification number: C07D471/04 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号：US20100324060A1
公开(公告)日：2010-12-23
申请号：US12818421
申请日：2010-06-18
Applicant: William E. Delaney , Hongmei Mo , Weidong Zhong
Inventor： William E. Delaney , Hongmei Mo , Weidong Zhong
IPC: A61K31/501 , A61P31/14
CPC classification number: A61K31/403 , A61K31/501 , A61K45/06 , A61K2300/00
Abstract: This invention relates to combinations of Compound 1 and Compound 2 which are useful for treating hepatitis C virus infection.
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