公开(公告)号：US20070203059A1

公开(公告)日：2007-08-30

申请号：US10573280

申请日：2004-09-20

Applicant: John Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

Inventor： John Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

IPC: A61K38/22 ,  G01N33/53

CPC classification number: G01N33/564 ,  A61K38/28 ,  A61K38/465 ,  A61K38/51 ,  C12N9/16 ,  G01N33/6854 ,  G01N2333/916 ,  G01N2800/042 ,  A61K2300/00

Abstract: A method and compositions for detecting autoimmunity to islet glucose-6 phosphatase related protein (IGRP). Detection of IGRP autoantibodies alone, and in combination with other molecules such as the 65-kDa form of glutamate decarboxylase (GAD65), insulin and insulin granule membrane proteins ICA512 (IA-2) and phogrin (IA-2) auto-antigens, provides an effective and reliable chemical assay for the diagnosis of autoimmune (type 1) diabetes. Additionally, this invention provides therapeutic regimens based on IGRP and related molecules for the amelioration of the diabetic clinical condition. Therefore, IGRP alone or in combination with other autoimmune diabetes associated antigens such as insulin, IA-2 and GAD65, is useful in the prediction (diagnosis), treatment (therapy), and prevention (prophylaxis) of diabetes.

Abstract translation: 用于检测胰岛葡萄糖-6-磷酸酶相关蛋白（IGRP）的自身免疫的方法和组合物。 检测单独的IGRP自身抗体，并与其他分子如65-kDa形式的谷氨酸脱羧酶（GAD 65 N），胰岛素和胰岛素颗粒膜蛋白ICA512（IA-2）和phogrin（IA -2）自身抗原，为自身免疫（1型）糖尿病的诊断提供了有效和可靠的化学分析。 此外，本发明提供了基于IGRP和相关分子用于改善糖尿病临床病症的治疗方案。 因此，IGRP单独或与其他自身免疫性糖尿病相关抗原如胰岛素，IA-2和GAD 65组合可用于预测（诊断），治疗（治疗）和预防（预防） 的糖尿病

公开(公告)号：US20100143374A1

公开(公告)日：2010-06-10

申请号：US12521022

申请日：2007-12-28

Applicant: John C. Hutton ,  Janet M. Wenzlau ,  Jan Jensen ,  Howard Davidson

Inventor： John C. Hutton ,  Janet M. Wenzlau ,  Jan Jensen ,  Howard Davidson

IPC: G01N33/566 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K19/00 ,  C07K16/46 ,  A61K39/395 ,  A61K38/17 ,  A61P3/10

CPC classification number: C07K14/705 ,  C07K14/47 ,  G01N33/564 ,  G01N2800/042 ,  G01N2800/52

Abstract: Described is the identification of ZnT8 as an autoantigen target in type I autoimmune diabetes (T1D), other autoimmune disease, and other diabetes-linked diseases and conditions. Also described are a variety of therapeutic, diagnostic, and prognostic tools and methods based on this discovery. The identification of genetic variation in ZnT8 as an important player in the initiation of the disease process and the progression of autoimmunity to clinical diabetes is disclosed.

Abstract translation: 描述了在I型自身免疫性糖尿病（T1D），其他自身免疫疾病和其他与糖尿病相关的疾病和病症中鉴定ZnT8作为自身抗原靶标。 还描述了基于该发现的各种治疗，诊断和预后工具和方法。 本发明公开了ZnT8中作为起始疾病过程中的重要参与者和临床糖尿病的自身免疫进展的遗传变异的鉴定。

公开(公告)号：US20070115004A1

公开(公告)日：2007-05-24

申请号：US11284354

申请日：2005-11-21

Applicant: Russell Mirov ,  Howard Davidson

Inventor： Russell Mirov ,  Howard Davidson

IPC: G01R31/04

CPC classification number: G01R31/312 ,  G01R31/046 ,  G01R31/2812 ,  G01R31/2853

Abstract: A system configured to detect faults in signal lines. A system includes a first component configured to communicate with a second component via a signal path including one or more signal traces. Sense signal lines are manufactured such that at some point they are in close proximity to a signal trace which is to be monitored. The sense signal lines are configured to use parasitic coupling to redirect a portion of a signal conveyed via a signal trace to a monitoring component. The first component is configured to convey a test signal indicative of a type of test via the signal path, and a reference signal to the monitoring component. The monitoring component is configured to utilize the reference signal to ascertain a presence or absence, or characteristics of a received redirected signal. The monitoring component may optionally utilize a locally generated reference signal.

Abstract translation: 被配置为检测信号线路中的故障的系统。 系统包括被配置为经由包括一个或多个信号迹线的信号路径与第二部件通信的第一部件。 感测信号线被制造成使得在某些点处它们处于要被监控的信号迹线附近。 感测信号线被配置为使用寄生耦合来将经由信号迹线传送的信号的一部分重定向到监视部件。 第一组件被配置为经由信号路径传送指示测试类型的测试信号，以及向监视组件传送参考信号。 监视组件被配置为利用参考信号来确定所接收的重定向信号的存在或不存在或特性。 监视组件可以可选地利用本地生成的参考信号。

公开(公告)号：US20060260699A1

公开(公告)日：2006-11-23

申请号：US10326714

申请日：2002-12-19

Applicant: Howard Edelman ,  Howard Davidson

Inventor： Howard Edelman ,  Howard Davidson

IPC: F16L37/32

CPC classification number: A61M39/1011 ,  A61F7/00 ,  A61M5/1408 ,  A61M39/223 ,  A61M39/26 ,  A61M2039/1027 ,  A61M2039/1083 ,  A61M2039/1088 ,  A61M2205/36 ,  Y10T137/87161 ,  Y10T137/87957

Abstract: A fluid circuit connector system includes a quick-release connector for connecting a set of tubes to an object. The quick-release connector includes a release button, a lock arm, a lock tab and a cavity configured to receive the tubes and a set of coupler housings. The connector system includes an object fitting having lock recess may be configured to receive the lock tab. The object fitting includes a cavity. The system further includes a set of male coupler housings each including a first unitary valve and a set of female coupler housings each including a second unitary valve. Each female housing is configured to receive and engage one of the male coupler housings. The system includes a set of seals configured to seal each male coupler housing and each female coupler housing when the quick-release connector is connected to the object fitting.

Abstract translation: 流体回路连接器系统包括用于将一组管连接到物体的快速释放连接器。 快速释放连接器包括释放按钮，锁定臂，锁定舌片和被构造成接收管子的腔和一组联接器壳体。 连接器系统包括具有锁定凹部的对象配件可以被配置为接收锁定突出部。 物体配件包括腔体。 该系统还包括一组阳联接器壳体，每个包括第一单一阀和一组阴联接器壳体，每个均包括第二整体阀。 每个阴壳体被构造成接收并接合阳联接器壳体中的一个。 该系统包括一组密封件，其构造成当快速连接器连接到物体接头时密封每个阳联接器壳体和每个阴联接器壳体。

公开(公告)号：US09023984B2

公开(公告)日：2015-05-05

申请号：US12521022

申请日：2007-12-28

Applicant: John C. Hutton ,  Janet M. Wenzlau ,  Jan Jensen ,  Howard Davidson

Inventor： John C. Hutton ,  Janet M. Wenzlau ,  Jan Jensen ,  Howard Davidson

IPC: C07K14/00 ,  C07K14/705 ,  C07K14/47 ,  G01N33/564

CPC classification number: C07K14/705 ,  C07K14/47 ,  G01N33/564 ,  G01N2800/042 ,  G01N2800/52

Abstract: Described is the identification of ZnT8 as an autoantigen target in type I autoimmune diabetes (T1D), other autoimmune disease, and other diabetes-linked diseases and conditions. Also described are a variety of therapeutic, diagnostic, and prognostic tools and methods based on this discovery. The identification of genetic variation in ZnT8 as an important player in the initiation of the disease process and the progression of autoimmunity to clinical diabetes is disclosed.

Abstract translation: 描述了在I型自身免疫性糖尿病（T1D），其他自身免疫疾病和其他与糖尿病相关的疾病和病症中鉴定ZnT8作为自身抗原靶标。 还描述了基于该发现的各种治疗，诊断和预后工具和方法。 本发明公开了ZnT8中作为起始疾病过程中的重要参与者和临床糖尿病的自身免疫进展的遗传变异的鉴定。

公开(公告)号：US08252572B2

公开(公告)日：2012-08-28

申请号：US12708441

申请日：2010-02-18

Applicant: John C. Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

Inventor： John C. Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

IPC: C12N9/00 ,  C07K14/00

CPC classification number: G01N33/564 ,  A61K38/28 ,  A61K38/465 ,  A61K38/51 ,  C12N9/16 ,  G01N33/6854 ,  G01N2333/916 ,  G01N2800/042 ,  A61K2300/00

Abstract: A method and compositions for detecting autoimmunity to islet glucose-6-phosphatase related protein (IGRP). Detection of IGRP autoantibodies alone, and in combination with other molecules such as the 65-kDa form of glutamate decarboxylase (GAD65), insulin and insulin granule membrane proteins ICA512 (IA-2) and phogrin (IA2β) auto-antigens, provides an effective and reliable chemical assay for the diagnosis of autoimmune (type 1) diabetes. Additionally, this invention provides therapeutic regimens based on IGRP and related molecules for the amelioration of the diabetic clinical condition. Therefore, IGRP alone or in combination with other autioimmune diabetes associated antigens such as insulin, IA-2 and GAD65, is useful in the prediction (diagnosis), treatment (therapy), and prevention (prophylaxis) of diabetes.

Abstract translation: 用于检测胰岛素葡萄糖-6-磷酸酶相关蛋白（IGRP）的自身免疫的方法和组合物。 检测单独的IGRP自身抗体，与其他分子如65-kDa形式的谷氨酸脱羧酶（GAD65），胰岛素和胰岛素颗粒膜蛋白ICA512（IA-2）和phogrin（IA2＆bgr）自身抗原组合，提供了一种 有效和可靠的化学测定用于诊断自身免疫（1型）糖尿病。 此外，本发明提供了基于IGRP和相关分子用于改善糖尿病临床病症的治疗方案。 因此，IGRP单独或与其他免疫缺陷型糖尿病相关抗原如胰岛素，IA-2和GAD65组合可用于糖尿病的预测（诊断），治疗（治疗）和预防（预防）。

公开(公告)号：US6097363A

公开(公告)日：2000-08-01

申请号：US983118

申请日：1992-11-30

Applicant: Howard Davidson

Inventor： Howard Davidson

IPC: G09G3/02 ,  G02B27/01 ,  G09G3/00 ,  G09G3/34 ,  H04N11/00 ,  H04N11/24 ,  G09G3/36

CPC classification number: G02B27/0172 ,  G02B27/017 ,  G09G3/002 ,  G09G3/02 ,  G09G2310/0235

Abstract: An arrangement for displaying the output of an electronic system such as a computer including a light gate array having a column of light windows; apparatus for providing red light to the windows of a column for a predetermined period; apparatus for providing green light to the windows of a column for a predetermined period; apparatus for providing blue light to the windows of a column for a predetermined period; apparatus for opening each of said windows for preselected periods during the periods in which light from the red, green, and blues sources are available; and apparatus for scanning the light transferred by the windows for viewing to focus at points defining columns of pixels.

Abstract translation: 一种用于显示诸如包括具有一列光窗口的光门阵列的计算机的电子系统的输出的装置; 用于在预定时间段内向列的窗口提供红光的装置; 用于在预定时间段内向列的窗口提供绿光的设备; 用于在预定时间段内向列的窗户提供蓝光的设备; 用于在来自红色，绿色和蓝色光源的光可用的时段期间将每个所述窗口打开预选时段的装置; 以及用于扫描由窗口传送以观看以聚焦在定义像素列的点处的光的装置。