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公开(公告)号：US20250009292A1
公开(公告)日：2025-01-09
申请号：US18707597
申请日：2022-11-09
Applicant: ICHILOV TECH LTD.
Inventor： Zvi IZAKSON MASIE
IPC: A61B5/00
Abstract: A method for determining an effect of anesthesia in a subject, including:
stimulating a body of a subject at one or more stimulation sites, wherein the subject is under regional anesthesia;
measuring a response of the subject to the stimulation, wherein said response passes through a nervous system of the subject;
determining an effect of the regional anesthesia on the subject body based on results of the measuring.-
公开(公告)号：US20240125766A1
公开(公告)日：2024-04-18
申请号：US18389949
申请日：2023-12-20
Applicant: ICHILOV TECH LTD.
Inventor： Ori ELKAYAM , Smadar GERTEL
IPC: G01N33/50 , C12Q1/6851 , G01N33/543
CPC classification number: G01N33/5008 , C12Q1/6851 , G01N33/54306 , G01N2333/525
Abstract: The present invention is directed to a method for determining the suitability of a subject to TNFα inhibitor therapy. Further provide is a method for treating a subject afflicted with a TNFα related disease.
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公开(公告)号：US20230321235A1
公开(公告)日：2023-10-12
申请号：US18020441
申请日：2021-08-11
Applicant: Yeda Research and Development Co. Ltd. , Ichilov Tech Ltd.
Inventor： Yair REISNER , Anat GLOBERSON LEVIN , Esther BACHAR-LUSTIG , Assaf LASK , Bar NATHANSOHN-LEVI , Tova WAKS , Galit HORN , Zelig ESHHAR
IPC: A61P35/00 , C12N5/0783 , A61K39/00
CPC classification number: A61K39/4611 , A61K39/4631 , A61P35/00 , C12N5/0636 , A61K2239/22 , C12N2510/00
Abstract: A method of generating a population of genetically modified veto cells is disclosed. The method comprising: (a) providing a population of cells comprising T cells, the T cells comprising at least 40% memory CD8+ T cells; (b) culturing the population of cells comprising T cells with an antigen or antigens under conditions which allow enrichment of tolerance-inducing antigen-specific cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being depleted of graft versus host (GVH) reactivity; and (c) transducing the cells with a polynucleotide encoding a heterologous cell surface receptor comprising a T cell receptor signaling module, thereby generating the population of genetically modified veto cells.
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公开(公告)号：US20230301295A1
公开(公告)日：2023-09-28
申请号：US18021650
申请日：2021-08-18
Applicant: ICHILOV TECH LTD. , A.A. Cash Technology Ltd.
Inventor： Nir SHANI , Eyal GUR , Shujun LI , Or FRIEDMAN , Amir ARAV
IPC: A01N1/02
CPC classification number: A01N1/0284 , A01N1/0252
Abstract: The present invention is directed to a method and a device for long-term cryopreservation of a biological sample, including a vascularized tissue, an innervated tissue, or both, such, but not limited to a limb.
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公开(公告)号：US20220204928A1
公开(公告)日：2022-06-30
申请号：US17604169
申请日：2020-04-16
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. , ICHILOV TECH LTD.
Inventor： Anat AHARON , Anat GLOBERSON LEVIN , Irit AVIVI , Galit HORN , Tova WAKS , Zelig ESHHAR
IPC: C12N5/0783 , C07K16/32 , C07K14/705 , C07K14/725 , A61K45/06 , A61K39/395 , A61K38/17 , A61P35/00 , A61K35/17 , C07K16/28
Abstract: The present invention provides extracellular vesicles (EVs) derived from T-cells expressing chimeric antigen receptors (CAR) specifically activated with an antigen to which the CAR bind specifically, pharmaceutical compositions comprising these vesicles as well as their use in treating cancer. In particular the present invention exemplifies EVs derived from activated T-cells expressing CAR that bind specifically to HER2 cancer antigen, pharmaceutical composition comprising these EVs and their use in treating a cancer overexpressing HER2, such as ovarian cancer and breast cancer.
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Patent Agency Ranking
公开(公告)号：US20220151542A1
公开(公告)日：2022-05-19
申请号：US17435906
申请日：2020-03-03
Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED , ICHILOV TECH LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Talma HENDLER , Asya ROLLS , Nitzan LUBIANIKER , Tamar KOREN , Neomi SINGER , Tamar BEN SHANNAN , Shai SHEN ORR , Fahed HAKIM , Hilla AZULAY DEBBY , Rani COHEN
Abstract: The present invention is directed to a method for inducing an immune response in a subject, including a step of activating neurons in the mesolimbic network of the subject by applying a neurofeedback.
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公开(公告)号：US20210324339A1
公开(公告)日：2021-10-21
申请号：US17327719
申请日：2021-05-23
Applicant: Ichilov Tech Ltd.
Inventor： Nadir ARBER , Shiran SHAPIRA
Abstract: A method of producing cell derived particles is disclosed. The method comprising isolating cell-derived particles from a biological sample comprising cells modified to present CD24 so as to obtain a preparation of the cell-derived particles substantially devoid of intact cells. Cell derived particles, a culture medium and a cell culture are also disclosed.
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公开(公告)号：US20240216510A1
公开(公告)日：2024-07-04
申请号：US18556172
申请日：2022-04-13
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , ICHILOV TECH LTD. , YEDA RESEARCH & DEVELOPMENT CO. LTD.
Inventor： Vered PADLER-KARAVANI , Ron AMON , Lihi NINIOMANY , Moran RAWET SLOBODKIN , Anat GLOBERSON LEVIN , Tova WAKS , Zelig ESHHAR
IPC: A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/30 , C12N5/0783
CPC classification number: A61K39/4631 , A61K39/4611 , A61K39/4613 , A61K39/464474 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70578 , C07K16/30 , C12N5/0636 , A61K2039/505 , C07K2317/622 , C07K2319/03 , C07K2319/30 , C12N2510/00
Abstract: The present invention discloses chimeric antigen receptors that specifically recognize and bind to Sialyl Tn carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.
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19.发明公开公开(公告)号：US20240164696A1
公开(公告)日：2024-05-23
申请号：US18283085
申请日：2022-03-24
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , ICHILOV TECH LTD.
Inventor： Ari DEROWE , Tal Yehuda BARKAI , Linor KLEIN , Mickey SCHEINOWITZ , Amir DAGAN
CPC classification number: A61B5/383 , A61B5/291 , A61B5/372 , A61B5/381 , A61B5/682 , A61B2503/06 , A61N1/0548
Abstract: Systems and methods for diagnosis of Acute Otitis Media (AOM) with a monopolar probe in a territory innervated by a chorda tympani nerve (CTN) by applying a stimulus by the monopolar, measuring a response to the stimulus, changing the strength of the stimulus applied based on the measured response until the measured response reaches a threshold value, determining a first stimulus strength at the threshold value, repeating these steps for another predefined location in a territory innervated by the CTN associated with a second ear, to determine a second stimulus strength at the threshold value for the second predefined location; and diagnosing AOM based on a difference between the determined first and second stimulus strengths for the first and second locations.
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公开(公告)号：US20240108272A1
公开(公告)日：2024-04-04
申请号：US18557965
申请日：2021-03-11
Applicant: ICHILOV TECH LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Talma HENDLER , Mordekhay MEDVEDOVSKY , Tomer GAZIT , Evgeny TSIZIN-GOLDMAN , Alexander BRONSTEIN
CPC classification number: A61B5/372 , A61B5/256 , A61B5/271 , A61B5/291 , A61B5/4094 , A61B5/7203 , A61B2562/046
Abstract: Provided herein are methods for EEG monitoring of a patient, which includes: positioning an array comprising a plurality of EEG electrodes on the patient's head; recording, during a first time period, a first data set of EEG signals from a first set of spatial scalp locations; manipulating the array to record, during a second time period, a second data set of EEG signals from a second set of spatial locations including at least some spatial scalp locations that are different from the first set of spatial scalp locations; integrating the first and second data sets, thereby generating a combined data set with a higher spatial density; and processing the combined data set to determine EEG events.
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