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公开(公告)号：US20110262304A1
公开(公告)日：2011-10-27
申请号：US12674941
申请日：2008-08-27
Applicant: James A. Profitt , Chris T. Zimmerle
Inventor： James A. Profitt , Chris T. Zimmerle
CPC classification number: G01N33/525
Abstract: Migration of liquid samples on diagnostic test strips is prevented by dividing the test strips into reagent-containing pads spaced about 0.3 to 3 mm apart with a laser.
Abstract translation: 通过用激光将测试条划分成间隔约0.3至3毫米的含试剂垫来防止液体样品在诊断测试条上的迁移。
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公开(公告)号：US20110111522A1
公开(公告)日：2011-05-12
申请号：US12674944
申请日：2008-08-27
Applicant: Chris T. Zimmerie , Michael J. Pugia , James A. Profitt
Inventor： Chris T. Zimmerie , Michael J. Pugia , James A. Profitt
CPC classification number: A61B10/007 , A61B90/90 , A61B90/96 , G01N33/558 , G01N35/00732 , G01N2035/00752 , G01N2035/00772
Abstract: Sample media for the analysis of analytes in a fluid test sample includes a carrier, at least one test field on the surface of the carrier including at least one reagent reactive with the analytes and capable of providing a detectable response. A non-visible bar code formed by at least two distinct non-visible marker fields is located on the carrier. The marker fields are configured to reflect electro-magnetic (EM) radiation within one or more ranges of non-visible wavelengths to form a coded sequence of reflectances correlated to identification of the sample media.
Abstract translation: 用于分析流体测试样品中的分析物的样品介质包括载体，载体表面上的至少一个测试场包括至少一种与分析物反应的试剂并且能够提供可检测的反应。 由至少两个不同的不可见标记字段形成的不可视条形码位于载体上。 标记场被配置为在不可见波长的一个或多个范围内反映电磁（EM）辐射，以形成与样本介质的识别相关的反射的编码序列。
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公开(公告)号：US20100239137A1
公开(公告)日：2010-09-23
申请号：US12681180
申请日：2008-10-06
Applicant: Michael J. Pugia , James A. Profitt , Chris T. Zimmerle
Inventor： Michael J. Pugia , James A. Profitt , Chris T. Zimmerle
CPC classification number: G01N33/54366 , G01N21/274 , G01N21/8483 , G01N2201/062
Abstract: A system for reading an assay includes a camera and a processor. The assay is used as a test for the presence or absence of a reaction between a sample and a reagent. The assay is defined by a test area and a background area. The test area is, preferably, substantially circular with a diameter between about 0.1 mm and about 5 mm. The camera simultaneously captures a two-dimensional image of the test area and the background area. The processor determines a first color response from the background area and a second color response from the test area. The processor then calibrates the second color response according to the first color response and generates a result of the test according to the second color response. The system may also include a uniform field illuminator that provides a substantially uniform level of illumination across the assay.
Abstract translation: 用于读取测定的系统包括照相机和处理器。 该测定用作样品和试剂之间存在或不存在反应的测试。 测定由测试区域和背景区域定义。 测试区域优选为直径在约0.1mm至约5mm之间的大致圆形。 相机同时捕获测试区域和背景区域的二维图像。 处理器确定来自背景区域的第一颜色响应和来自测试区域的第二颜色响应。 然后处理器根据第一颜色响应校准第二颜色响应，并根据第二颜色响应生成测试结果。 该系统还可以包括统一的场照明器，其在整个测定中提供基本均匀的照明水平。
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公开(公告)号：US20090041627A1
公开(公告)日：2009-02-12
申请号：US12205949
申请日：2008-09-08
Applicant: Michael J. Pugia , James A. Profitt , Ronald G. Sommer , Sung-Kwon Jung
Inventor： Michael J. Pugia , James A. Profitt , Ronald G. Sommer , Sung-Kwon Jung
CPC classification number: B01L3/502707 , B01L2200/142 , B01L2200/16 , B01L2300/0672 , B01L2400/0406 , B01L2400/0677 , B01L2400/0683 , B29K2509/08
Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.
Abstract translation: 包含具有延长的保存期限的液体试剂的微流体装置包含微储存器中的液体试剂，其在装置的保存期限内将水分逸出限制在小于10％。 微型储存器优选由聚丙烯制成并用金属化塑料膜覆盖。
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公开(公告)号：US5140027A
公开(公告)日：1992-08-18
申请号：US522932
申请日：1990-05-14
Applicant: Helen H. Ong , Vernon B. Anderson , James A. Profitt
Inventor： Helen H. Ong , Vernon B. Anderson , James A. Profitt
IPC: C07D313/14
CPC classification number: C07D313/14
Abstract: Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.
Abstract translation: 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。
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Patent Agency Ranking
公开(公告)号：US4672138A
公开(公告)日：1987-06-09
申请号：US825725
申请日：1986-02-03
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07C45/63 , C07C333/02 , C07D333/52 , C07D333/54 , C07D333/56 , C07D333/64 , C07D333/76 , C07C155/02
CPC classification number: C07D333/54 , C07C309/00 , C07C323/00 , C07C45/63 , C07D333/56 , C07D333/64 , C07D333/76
Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.
Abstract translation: 公开了新的苯并[b]噻吩，含有它们的组合物，其制备方法和通过施用化合物和组合物降低血压和产生利尿的方法。
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公开(公告)号：US4537976A
公开(公告)日：1985-08-27
申请号：US558074
申请日：1983-12-05
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07C45/63 , C07D333/54 , C07D333/56 , C07D333/64 , C07D333/76
CPC classification number: C07D333/54 , C07C309/00 , C07C323/00 , C07C45/63 , C07D333/56 , C07D333/64 , C07D333/76
Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.
Abstract translation: 公开了新的苯并[b]噻吩，含有它们的组合物，其制备方法和通过施用化合物和组合物降低血压和产生利尿的方法。
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公开(公告)号：US4307235A
公开(公告)日：1981-12-22
申请号：US121824
申请日：1980-02-15
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07D211/64 , C07D471/10
CPC classification number: C07D471/10 , C07D211/64
Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。
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公开(公告)号：US4198418A
公开(公告)日：1980-04-15
申请号：US2348
申请日：1979-01-10
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: A61K31/435 , A61P25/04 , A61P25/20 , C07C43/225 , C07C43/23 , C07D211/64 , C07D491/10 , C07D491/107 , A61K31/44 , A61K31/55
CPC classification number: C07D491/10 , C07C43/225 , C07C43/23 , C07D211/64
Abstract: Novel spiro[dibenz(b,f)oxepin-piperidine]s and methods of preparing same are described. These compounds are useful as analgetics, tranquilizers and anticonvulsants.
Abstract translation: 描述了新的螺[二苯并（b，f）氧杂七环素 - 哌啶]和其制备方法。 这些化合物可用作止痛药，止痛药和抗惊厥药。
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公开(公告)号：US20130004988A1
公开(公告)日：2013-01-03
申请号：US13608081
申请日：2012-09-10
Applicant: Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
Inventor： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
CPC classification number: B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
Abstract: Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
Abstract translation: 通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。 在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。 在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。 从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。
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