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    Non-visible detectable marking for medical diagnostics
    2.
    发明授权
    Non-visible detectable marking for medical diagnostics 有权
    用于医疗诊断的不可见的可检测标记

    公开(公告)号：US09439630B2

    公开(公告)日：2016-09-13

    申请号：US12674944

    申请日：2008-08-27

    Applicant: Chris T. Zimmerle ,  Michael J. Pugia ,  James A. Profitt

    Inventor： Chris T. Zimmerle ,  Michael J. Pugia ,  James A. Profitt

    IPC: G01N33/543 ,  A61B10/00 ,  G01N33/558 ,  G01N35/00

    CPC classification number: A61B10/007 ,  A61B90/90 ,  A61B90/96 ,  G01N33/558 ,  G01N35/00732 ,  G01N2035/00752 ,  G01N2035/00772

    Abstract: Sample media for the analysis of analytes in a fluid test sample includes a carrier, at least one test field on the surface of the carrier including at least one reagent reactive with the analytes and capable of providing a detectable response. A non-visible bar code formed by at least two distinct non-visible marker fields is located on the carrier. The marker fields are configured to reflect electro-magnetic (EM) radiation within one or more ranges of non-visible wavelengths to form a coded sequence of reflectances correlated to identification of the sample media.

    Abstract translation: 用于分析流体测试样品中的分析物的样品介质包括载体，载体表面上的至少一个测试场包括至少一种与分析物反应的试剂并且能够提供可检测的反应。 由至少两个不同的不可见标记字段形成的不可视条形码位于载体上。 标记场被配置为在不可见波长的一个或多个范围内反映电磁（EM）辐射，以形成与样本介质的识别相关的反射的编码序列。

    Two Dimensional Imaging of Reacted Areas On a Reagent
    4.
    发明申请
    Two Dimensional Imaging of Reacted Areas On a Reagent 审中-公开
    反应区域的二维成像在试剂上

    公开(公告)号：US20100239137A1

    公开(公告)日：2010-09-23

    申请号：US12681180

    申请日：2008-10-06

    Applicant: Michael J. Pugia ,  James A. Profitt ,  Chris T. Zimmerle

    Inventor： Michael J. Pugia ,  James A. Profitt ,  Chris T. Zimmerle

    IPC: G06K9/00 ,  H04N7/18

    CPC classification number: G01N33/54366 ,  G01N21/274 ,  G01N21/8483 ,  G01N2201/062

    Abstract: A system for reading an assay includes a camera and a processor. The assay is used as a test for the presence or absence of a reaction between a sample and a reagent. The assay is defined by a test area and a background area. The test area is, preferably, substantially circular with a diameter between about 0.1 mm and about 5 mm. The camera simultaneously captures a two-dimensional image of the test area and the background area. The processor determines a first color response from the background area and a second color response from the test area. The processor then calibrates the second color response according to the first color response and generates a result of the test according to the second color response. The system may also include a uniform field illuminator that provides a substantially uniform level of illumination across the assay.

    Abstract translation: 用于读取测定的系统包括照相机和处理器。 该测定用作样品和试剂之间存在或不存在反应的测试。 测定由测试区域和背景区域定义。 测试区域优选为直径在约0.1mm至约5mm之间的大致圆形。 相机同时捕获测试区域和背景区域的二维图像。 处理器确定来自背景区域的第一颜色响应和来自测试区域的第二颜色响应。 然后处理器根据第一颜色响应校准第二颜色响应，并根据第二颜色响应生成测试结果。 该系统还可以包括统一的场照明器，其在整个测定中提供基本均匀的照明水平。

    Total protein detection methods and devices
    8.
    发明授权
    Total protein detection methods and devices 有权
    总蛋白检测方法和装置

    公开(公告)号：US06815210B1

    公开(公告)日：2004-11-09

    申请号：US10480314

    申请日：2003-12-11

    Applicant: James A. Profitt ,  Alexander H. Orn ,  Jennifer Farr

    Inventor： James A. Profitt ,  Alexander H. Orn ,  Jennifer Farr

    IPC: G01N2178

    CPC classification number: G01N33/6839 ,  G01N33/543

    Abstract: An assay for the determination of protein in an aqueous test fluid which combines the test fluid with a buffer and a dye. The buffer is selected from citrulline, malonic acid, cyanoacetic acid, citraconic acid, methyl phosphonic acid, sarcosine, saccharin, or combinations thereof. The buffer is added in sufficient quantity to maintain the pH of the assay including the test fluid at a selected target pH range within a range of from about 2.0 to about 3.0. The dye has a pKa which enables it to operate as a protein indicator at the target pH range. The dye also has affinity for protein such that it will provide a detectable response in the presence of greater than about 15 mg/dL protein to thereby render the assay suitable for the detection of total protein in the test fluid. The buffer and dye may be absorbed in a test strip of absorbent material.

    Abstract translation: 在测试流体与缓冲液和染料组合的水性测试流体中测定蛋白质的测定法。 缓冲液选自瓜氨酸，丙二酸，氰基乙酸，柠康酸，甲基膦酸，肌氨酸，糖精或其组合。 以足够的量加入缓冲液，以将测定液的pH值保持在约2.0至约3.0范围内的选定目标pH范围。 染料具有使其能够在目标pH范围内作为蛋白质指示剂操作的pKa。 染料还对蛋白质具有亲和力，使得其在大于约15mg / dL蛋白质的存在下提供可检测的响应，从而使测定法适合于检测测试流体中的总蛋白质。 缓冲液和染料可以吸收在吸收材料的测试条中。

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