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28 条记录 (耗时 0.029 秒)

    EEPROM cell and related method of making thereof
    11.
    发明授权
    EEPROM cell and related method of making thereof 失效
    EEPROM单元具有改进的拓扑结构和减少的漏电流

    公开(公告)号：US5953602A

    公开(公告)日：1999-09-14

    申请号：US978028

    申请日：1997-11-25

    申请人： Han Su Oh ,  Jang Han Kim

    发明人： Han Su Oh ,  Jang Han Kim

    IPC分类号： H01L21/336 ,  H01L29/423 ,  H01L29/788 ,  H01L21/8238

    CPC分类号： H01L29/66825 ,  H01L29/42336 ,  H01L29/7883

    摘要： An EEPROM cell of reduced leakage current during erasure and improved cell topology includes a first conductivity type substrate having a channel region, a trench formed in the channel region of the substrate, first spacers formed on opposed sidewalls of the trench, and a gate oxide film formed at the bottom of the trench between the first spacers. Second conductivity type source/drain regions are formed in the substrate at opposite side of the trench. A tunneling oxide film is further provided on the substrate overlying the drain region and proximate the trench. An insulation film is provided over the entire substrate surface except the trench and the tunneling oxide film. In addition, a floating gate is formed on the insulation film over the source and drain regions, as well as the gate oxide film at the trench bottom. Second spacers are provided on the insulation film at opposed side surfaces of the floating gate. A dielectric film is then provided on the surface of the floating gate and the second spacers, and a control gate is formed on the dielectric film.

    摘要翻译： 在擦除期间减小的漏电流和改进的电池拓扑的EEPROM单元包括具有沟道区的第一导电型衬底，形成在衬底的沟道区中的沟槽，形成在沟槽的相对侧壁上的第一衬垫和栅氧化膜 形成在第一间隔物之间​​的沟槽的底部。 在沟槽的相对侧的衬底中形成第二导电类型的源极/漏极区域。 隧道氧化膜还设置在衬底上，覆盖漏极区域并且靠近沟槽。 除了沟槽和隧道氧化物膜之外，在整个衬底表面上提供绝缘膜。 此外，在源极和漏极区域上的绝缘膜上以及沟槽底部的栅极氧化物膜上形成浮栅。 第二间隔件设置在浮动栅极的相对侧表面处的绝缘膜上。 然后在浮置栅极和第二间隔物的表面上提供电介质膜，并且在电介质膜上形成控制栅极。

    MODIFIED SMALL INTERFERING RNA MOLECULES AND METHODS OF USE
    17.
    发明申请
    MODIFIED SMALL INTERFERING RNA MOLECULES AND METHODS OF USE 有权

    公开(公告)号：US20150148402A1

    公开(公告)日：2015-05-28

    申请号：US14274127

    申请日：2014-05-09

    申请人： Jang HAN ,  Michael HOUGHTON

    发明人： Jang HAN ,  Michael HOUGHTON

    IPC分类号： A61K31/713 ,  A61K45/06

    CPC分类号： C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/322 ,  C12N2310/3515 ,  C12N2310/3533 ,  C12N2320/31

    摘要： The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA (dsRNA) molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer. The invention provides modified RNA molecules that are modified to include a dsRNA or siRNA wherein one or more of the pyrimidines in the RNA molecule are modified to include 2′-Fluorine. The invention also provides dsRNA or siRNA in which all pyrimidines are modified to include a 2′-Fluorine. The invention provides that the 2′-Fluorine dsRNA or siRNA molecule is further modified to include a two base deoxynucleotide “TT” sequence at the 3′ end of the molecule.

    Modified small interfering RNA molecules and methods of use
    18.
    发明授权
    Modified small interfering RNA molecules and methods of use 失效
    修饰的小干扰RNA分子和使用方法

    公开(公告)号：US08765704B1

    公开(公告)日：2014-07-01

    申请号：US13325308

    申请日：2011-12-14

    申请人： Jang Han ,  Michael Houghton

    发明人： Jang Han ,  Michael Houghton

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/322 ,  C12N2310/3515 ,  C12N2310/3533 ,  C12N2320/31

    摘要： The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA (dsRNA) molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer. The invention provides modified RNA molecules that are modified to include a dsRNA or siRNA wherein one or more of the pyrimidines in the RNA molecule are modified to include 2′-Fluorine. The invention also provides dsRNA or siRNA in which all pyrimidines are modified to include a 2′-Fluorine. The invention provides that the 2′-Fluorine dsRNA or siRNA molecule is further modified to include a two base deoxynucleotide “TT” sequence at the 3′ end of the molecule.

    摘要翻译： 本发明提供了介导靶细胞，优选肝细胞中的RNA干扰的双链RNA分子。 本发明还提供被修饰为对核酸酶降解具有抗性的双链RNA（dsRNA）分子，其使病毒失活，更具体地，丙型肝炎病毒（HCV）。 本发明还提供了使用这些修饰的RNA分子来灭活哺乳动物细胞中的病毒的方法和使用人Dicer制备修饰的小干扰RNA（siRNA）的方法。 本发明提供经修饰以包括dsRNA或siRNA的修饰的RNA分子，其中RNA分子中的一个或多个嘧啶被修饰为包括2'-氟。 本发明还提供dsRNA或siRNA，其中所有嘧啶被修饰以包括2'-氟。 本发明提供了2'-氟dsRNA或siRNA分子被进一步修饰，以在分子的3'端包括两碱基脱氧核苷酸“TT”序列。

    Providing an electronic marketplace to facilitate human performance of programmatically submitted tasks
    20.
    发明授权
    Providing an electronic marketplace to facilitate human performance of programmatically submitted tasks 有权
    提供电子市场，促进人性化编程提交的任务

    公开(公告)号：US08306840B2

    公开(公告)日：2012-11-06

    申请号：US12510192

    申请日：2009-07-27

    申请人： Peter D. Cohen ,  Daniel A. Sanderson ,  Mikhail Seregine ,  Brett Kiefer ,  Jang Han Goo ,  Jeffrey P. Bezos

    发明人： Peter D. Cohen ,  Daniel A. Sanderson ,  Mikhail Seregine ,  Brett Kiefer ,  Jang Han Goo ,  Jeffrey P. Bezos

    IPC分类号： G06F9/46

    CPC分类号： G06F9/5005 ,  G06Q10/06 ,  G06Q10/06311 ,  G06Q10/063112 ,  G06Q30/0601 ,  G06Q30/08 ,  G06Q40/04

    摘要： A method, system, and computer-readable medium is described for facilitating interactions between task requesters who have tasks that are available to be performed and task performers who are available to perform tasks. In some situations, the tasks to be performed are human performance tasks that use cognitive and other mental skills of human task performers, such as to employ judgment, perception and/or reasoning skills of the human task performers. In addition, in some situations the available tasks are submitted by human task requesters via application programs that programmatically invoke one or more application program interfaces of an electronic marketplace in order to request that the tasks be performed and to receive corresponding results of task performance in a programmatic manner, so that an ensemble of unrelated human agents can interact with the electronic marketplace to collectively perform a wide variety and large number of tasks.

    摘要翻译： 描述了一种方法，系统和计算机可读介质，用于促进具有可执行任务的任务请求者与可执行任务的任务执行者之间的交互。 在某些情况下，要执行的任务是使用人类任务执行者的认知和其他心理技能的人类执行任务，例如采用人类任务执行者的判断，感知和/或推理技能。 此外，在某些情况下，可用任务由人工任务请求者通过程序化地调用电子市场的一个或多个应用程序接口的应用程序提交，以便请求执行任务并且接收相应的任务执行结果 使得一系列无关的人类代理可以与电子市场相互作用，共同执行各种各样的大量任务。