Patent search ap:"Jason McCartney" Page 2

11.

发明授权
Modulators of ATP-binding cassette transporters 有权
Title translation: ATP结合盒转运蛋白的调节剂

公开(公告)号：US07659268B2

公开(公告)日：2010-02-09

申请号：US11804726

申请日：2007-05-18

Applicant: Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor

Inventor： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor

IPC: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4418 , A61K31/443 , C07D413/00 , C07D401/00 , C07D213/02 , C07D405/00

CPC classification number: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

12.

发明授权
Indole derivatives as CFTR modulators 有权
Title translation: 吲哚衍生物作为CFTR调节剂

公开(公告)号：US07645789B2

公开(公告)日：2010-01-12

申请号：US11975297

申请日：2007-10-18

Applicant: Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa

Inventor： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa

IPC: A61K31/36 , C07D405/12

CPC classification number: A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

13.

发明申请
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权
Title translation: ATP结合蛋白转运蛋白的调节剂

公开(公告)号：US20090298876A1

公开(公告)日：2009-12-03

申请号：US12351447

申请日：2009-01-09

Applicant: Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney

Inventor： Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney

IPC: A61K31/4709 , A61P3/06 , A61P43/00 , A61P3/10 , A61P35/00 , A61P25/28 , A61P25/16

CPC classification number: C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

14.

发明授权
Modulators of ATP-binding cassette transporters 有权
Title translation: ATP结合盒转运蛋白的调节剂

公开(公告)号：US07495103B2

公开(公告)日：2009-02-24

申请号：US11165818

申请日：2005-06-24

Applicant: Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney

Inventor： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney

IPC: C07D215/38 , A61K31/44

CPC classification number: C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

15.

发明申请
Modulators of ATP-binding cassette transporters 有权

公开(公告)号：US20080009524A1

公开(公告)日：2008-01-10

申请号：US11824606

申请日：2007-06-29

Applicant: Sara Hadida Ruah , Mark Miller , Brian Bear , Jason McCartney , Peter Grootenhuis

Inventor： Sara Hadida Ruah , Mark Miller , Brian Bear , Jason McCartney , Peter Grootenhuis

IPC: A61K31/357 , A61K31/167 , A61K31/428 , A61P11/00 , A61P25/00 , A61P35/00 , C07C311/16 , C07D405/12 , C07D513/00 , C07D317/46 , C07C233/65 , A61P3/00 , A61P21/00 , A61K31/443 , A61K31/18

CPC classification number: C07D317/68

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

16.

发明申请
Modulators of ATP-binding cassette transporters 有权
Title translation: ATP结合盒转运蛋白的调节剂

公开(公告)号：US20070244159A1

公开(公告)日：2007-10-18

申请号：US11786001

申请日：2007-04-09

Applicant: Sara Hadida Ruah , Peter Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark Miller , Jason McCartney , Mehdi Numa

Inventor： Sara Hadida Ruah , Peter Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark Miller , Jason McCartney , Mehdi Numa

IPC: A61K31/454 , A61K31/42 , A61K31/4178 , A61K31/405 , C07D413/02 , C07D403/02

CPC classification number: C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

17.

发明授权
Modulators of ATP-binding cassette transporters 有权

公开(公告)号：US08846753B2

公开(公告)日：2014-09-30

申请号：US13928719

申请日：2013-06-27

Applicant: Sara S Hadida Ruah , Mark T. Miller , Brian Bear , Jason McCartney , Peter D. J. Grootenhuis

Inventor： Sara S Hadida Ruah , Mark T. Miller , Brian Bear , Jason McCartney , Peter D. J. Grootenhuis

IPC: A61K31/357 , C07D317/54

CPC classification number: C07D498/04 , A61K31/167 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/437 , A61K31/443 , A61K31/519 , A61K31/538 , A61K45/06 , C07C235/16 , C07D207/48 , C07D317/54 , C07D317/60 , C07D317/68 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

18.

发明申请
Modulators of ATP-Binding Cassette Transporters 有权
Title translation: ATP结合盒转运蛋白的调节剂

公开(公告)号：US20130296306A1

公开(公告)日：2013-11-07

申请号：US13928719

申请日：2013-06-27

Applicant: Sara S Hadida Ruah , Mark T. Miller , Brian Bear , Jason McCartney , Peter D.J. Grootenhuis

Inventor： Sara S Hadida Ruah , Mark T. Miller , Brian Bear , Jason McCartney , Peter D.J. Grootenhuis

IPC: C07D317/60

CPC classification number: C07D498/04 , A61K31/167 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/437 , A61K31/443 , A61K31/519 , A61K31/538 , A61K45/06 , C07C235/16 , C07D207/48 , C07D317/54 , C07D317/60 , C07D317/68 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。